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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

Published in:

01-05-2019 | Original Article

Expression of lubricin in rat posterior mandibular condylar cartilage following functional mandibular forward repositioning

Authors: Zheng Chen, Zhihui Mai, Shaoqin Tu, Hongfei Lu, Lin Chen, Hong Ai

Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie | Issue 3/2019

Abstract

Purpose

The aim of the present study was to investigate the effects of mandibular forward repositioning on expression of lubricin in rat posterior condylar cartilage.

Methods

In total, fifty 5‑week-old female Sprague Dawley rats were divided randomly into experimental groups and control groups. The animals in the experimental groups were fitted with modified acrylic inclined planes to advance the mandible, whereas rats in the normal control groups were left intact. Rats were sacrificed on days 3, 7, 14, 21, and 30, and temporomandibular joint (TMJ) samples were collected. The expression of lubricin of the posterior mandibular condylar cartilage was evaluated by immunohistochemistry.

Results

In the control groups, higher expression of lubricin was observed in the proliferative zone of the posterior mandibular condylar cartilage compared with the hypertrophic zone during the experimental period. Compared with the control group, the positive signals for lubricin of the posterior mandibular condylar cartilage in the experimental animals were significantly higher on days 7, 14, and 21; however, no statistical difference was found on day 3 or 30.

Conclusions

Data analyses suggest that the bite jumping appliance temporarily enhanced lubricin expression, providing a good mechanical environment for the physiologic growth of the condyle and mandible, and contributes to TMJ remodeling by the regulation of condylar chondrocyte proliferation.

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Title: Expression of lubricin in rat posterior mandibular condylar cartilage following functional mandibular forward repositioning
Authors: Zheng Chen
Zhihui Mai
Shaoqin Tu
Hongfei Lu
Lin Chen
Hong Ai
Publication date: 01-05-2019
Publisher: Springer Medizin
Published in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie / Issue 3/2019
Print ISSN: 1434-5293
Electronic ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-019-00173-x

At a glance: The STEP trials

Springer Medicine

Expression of lubricin in rat posterior mandibular condylar cartilage following functional mandibular forward repositioning

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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