Top

Published in:

01-10-2017 | Letter to the Editor

Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma

Authors: Francesco Cicone, Giuseppe Minniti, Maria Antonietta Oliva, Luciano Carideo, John O. Prior, Francesco Scopinaro, Felice Giangaspero, Antonietta Arcella

Published in: Brain Tumor Pathology | Issue 4/2017

Excerpt

To the Editor, …

Jin SE, Jin HE, Hong SS (2015) Targeting l-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics. Expert Opin Ther Targets 19:1319–1337CrossRefPubMed

Nawashiro H, Otani N, Uozumi Y, Ooigawa H, Toyooka T, Suzuki T, Katoh H, Tsuzuki N, Ohnuki A, Shima K, Shinomiya N, Matsuo H, Kanai Y (2005) High expression of l-type amino acid transporter 1 in infiltrating glioma cells. Brain Tumor Pathol 22:89–91CrossRefPubMed

Nawashiro H, Otani N, Shinomiya N, Fukui S, Ooigawa H, Shima K, Matsuo H, Kanai Y, Endou H (2006) l-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int J Cancer 119:484–492CrossRefPubMed

Haining Z, Kawai N, Miyake K, Okada M, Okubo S, Zhang X, Fei Z, Tamiya T (2012) Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas. BMC Clin Pathol 12:4CrossRefPubMedPubMedCentral

Youland RS, Kitange GJ, Peterson TE, Pafundi DH, Ramiscal JA, Pokorny JL, Giannini C, Laack NN, Parney IF, Lowe VJ, Brinkmann DH, Sarkaria JN (2013) The role of LAT1 in (18)F-DOPA uptake in malignant gliomas. J Neurooncol 111:11–18CrossRefPubMed

Habermeier A, Graf J, Sandhöfer BF, Boissel JP, Roesch F, Closs EI (2015) System l amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-l-tyrosine (FET). Amino Acids 47:335–344CrossRefPubMed

Albert NL, Weller M, Suchorska B, Galldiks N, Soffietti R, Kim MM, la Fougère C, Pope W, Law I, Arbizu J, Chamberlain MC, Vogelbaum M, Ellingson BM, Tonn JC (2016) Response assessment in neuro-oncology working group and European association for neuro-oncology recommendations for the clinical use of PET imaging in gliomas. Neuro Oncol 18:1199–1208CrossRefPubMedPubMedCentral

Filss CP, Cicone F, Shah NJ, Galldiks N, Langen KJ (2017) Amino acid PET and MR perfusion imaging in brain tumors. Clin Transl Imaging 5:209–223CrossRefPubMedPubMedCentral

Cicone F, Clerico A, Minniti G, Paiano M, Carideo L, Scaringi C, Langen KJ, Scopinaro F (2016) (18)F-DOPA positron emission tomography in medulloblastoma: 2 case reports. World Neurosurg 93:490.e7–490.e11CrossRef

10.

Northcott PA, Jones DT, Kool M, Robinson GW, Gilbertson RJ, Cho YJ, Pomeroy SL, Korshunov A, Lichter P, Taylor MD, Pfister SM (2012) Medulloblastomics: the end of the beginning. Nat Rev Cancer 12:818–834CrossRefPubMedPubMedCentral

Title: Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma
Authors: Francesco Cicone
Giuseppe Minniti
Maria Antonietta Oliva
Luciano Carideo
John O. Prior
Francesco Scopinaro
Felice Giangaspero
Antonietta Arcella
Publication date: 01-10-2017
Publisher: Springer Singapore
Published in: Brain Tumor Pathology / Issue 4/2017
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-017-0296-6

At a glance: The STEP trials

Springer Medicine

Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 4/2017

Modified rapid immunohistochemical staining for intraoperative diagnosis of malignant brain tumors

Downregulation of SMARCB1/INI1 expression in pediatric chordomas correlates with upregulation of miR-671-5p and miR-193a-5p expressions

Updated 2016 WHO classification of tumors of the CNS: turning the corner where molecule meets pathology

Diencephalic pediatric low-grade glioma harboring the BRAF V600E mutation presenting with various morphologies in sequential biopsy specimens

Encouraging option of multi-staged gross total resection for a C11orf-RelA fusion-positive supratentorial anaplastic ependymoma

Long-term epilepsy-associated tumor in the amygdala of a 16-year-old boy: report of a rare case having intranuclear filaments