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01-10-2017 | Rapid Short Communication

Downregulation of SMARCB1/INI1 expression in pediatric chordomas correlates with upregulation of miR-671-5p and miR-193a-5p expressions

Authors: Prit Benny Malgulwar, Pankaj Pathak, Manmohan Singh, Shashank Sharad Kale, Vaishali Suri, Chitra Sarkar, Mehar Chand Sharma

Published in: Brain Tumor Pathology | Issue 4/2017

Abstract

Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas (CCs). Although mutation/loss of 22q has strongly established the loss of SMARCB1/INI1 in cancers, the cause in CCs remains elusive. Recent studies suggest role of miRNAs in regulation of SMARCB1/INI1 expressions. We examined 5 reported/target predicted miRNAs to SMARCB1/INI1 in SMARCB1/INI1 immunonegative and immunopositive cases, and found upregulation of miR-671-5p and miR-193a-5p in SMARCB1/INI1-immunonegative cases. Notably, these two miRNAs were significantly predicted to target TGF-β signaling, suggestive of dysregulation of developmental and osteoblast regulation pathway in CCs. Overall, we suggest miR-671-5p- and miR-193a-5p-mediated epigenetic mode of SMARCB1/INI1 loss and downregulated TGF-β pathway in CCs.

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Title: Downregulation of SMARCB1/INI1 expression in pediatric chordomas correlates with upregulation of miR-671-5p and miR-193a-5p expressions
Authors: Prit Benny Malgulwar
Pankaj Pathak
Manmohan Singh
Shashank Sharad Kale
Vaishali Suri
Chitra Sarkar
Mehar Chand Sharma
Publication date: 01-10-2017
Publisher: Springer Singapore
Published in: Brain Tumor Pathology / Issue 4/2017
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-017-0295-7

At a glance: The STEP trials

Springer Medicine

Downregulation of SMARCB1/INI1 expression in pediatric chordomas correlates with upregulation of miR-671-5p and miR-193a-5p expressions

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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