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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2001

Open Access 01-11-2001 | Research article

Expression of interleukin-18 receptor in fibroblast-like synoviocytes

Authors: Burkhard Möller, Uta Kessler, Stefan Rehart, Uwe Kalina, Oliver G Ottmann, Joachim Peter Kaltwasser, Dieter Hoelzer, Natasa Kukoc-Zivojnov

Published in: Arthritis Research & Therapy | Issue 2/2001

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Abstract

An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R α-chain and β-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA.
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Metadata
Title
Expression of interleukin-18 receptor in fibroblast-like synoviocytes
Authors
Burkhard Möller
Uta Kessler
Stefan Rehart
Uwe Kalina
Oliver G Ottmann
Joachim Peter Kaltwasser
Dieter Hoelzer
Natasa Kukoc-Zivojnov
Publication date
01-11-2001
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2001
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar390

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