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European Archives of Oto-Rhino-Laryngology

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01-05-2018 | Head and Neck

Expression of hormone receptors in oropharyngeal squamous cell carcinoma

Authors: Hesham Mohamed, Katri Aro, Lauri Jouhi, Antti Mäkitie, Satu Remes, Caj Haglund, Timo Atula, Jaana Hagström

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2018

Abstract

Objectives

Hormone receptors play an important role in many types of cancers. Alongside factors associated with human papillomavirus (HPV) infection, hormonal receptors may impact the tumorigenesis of oropharyngeal cancer.

Materials and methods

This study consists of 199 consecutive oropharyngeal squamous cell carcinoma (OPSCC) patients diagnosed and treated with a curative intent. We examined androgen (AR), estrogen (ER; both alpha and beta), and progesterone receptor (PR) expressions using immunohistochemistry comparing tumor and patient characteristics.

Results

AR was expressed in 16%, PR in 27% and ER-beta in 63% of the tumors. HPV- and p16-positive tumors expressed more AR and less PR than their negative counterparts. High PR expression was associated with poor disease-specific and locoregional recurrence-free survival.

Conclusion

AR, PR, and ER-beta are expressed in OPSCC, and AR and PR expressions are associated with HPV and p16 status. Furthermore, PR appears to have prognostic significance. This may allow us to investigate the role of anti-hormone receptors in the treatment of OPSCC.

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Title: Expression of hormone receptors in oropharyngeal squamous cell carcinoma
Authors: Hesham Mohamed
Katri Aro
Lauri Jouhi
Antti Mäkitie
Satu Remes
Caj Haglund
Timo Atula
Jaana Hagström
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 5/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-4949-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Expression of hormone receptors in oropharyngeal squamous cell carcinoma

Abstract

Objectives

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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