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01-11-2014 | Research Article

Expression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma

Authors: Yan Song, Yuan Tian, Wei-liang Bai, Xiu-lan Ma

Published in: Tumor Biology | Issue 11/2014

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs of endogenous origin that play an important role in tumor development. Here, we examined the role of miR-152 in supragalottic laryngeal carcinoma. The expression of miR-152 was assessed by real-time PCR in tissues from 83 patients with supragalottic laryngeal carcinoma in relation to clinicopathological parameters. Cell viability was assessed by thiazolyl blue assay in Hep-2 cells transfected with miR-152 mimics or a negative control. MiR-152 was significantly downregulated in supragalottic laryngeal carcinoma tissues (t = 12.65, p < 0.001, paired t test), and its expression was correlated with pT stage (χ ² = 26.88, p < 0.001) and pN stage (z = −3.56, p < 0.001) in patients with supragalottic laryngeal carcinoma. MiR-152 inhibited the proliferation of Hep-2 cells. MiR-152 may serve as a novel prognostic marker in patients with supragalottic laryngeal carcinoma.

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Title: Expression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma
Authors: Yan Song
Yuan Tian
Wei-liang Bai
Xiu-lan Ma
Publication date: 01-11-2014
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 11/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2406-y

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