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Tobacco Induced Diseases
Published in: Tobacco Induced Diseases 1/2017

Open Access 01-12-2017 | Review

Experimental animal models for COPD: a methodological review

Authors: Vahideh Ghorani, Mohammad Hossein Boskabady, Mohammad Reza Khazdair, Majid Kianmeher

Published in: Tobacco Induced Diseases | Issue 1/2017

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Abstract

Introduction

Chronic obstructive pulmonary disease (COPD) is a progressive disorder that makes the breathing difficult and is characterized by pathological conditions ranging from chronic inflammation to tissue proteolysis. With regard to ethical issues related to the studies on patients with COPD, the use of animal models of COPD is inevitable. Animal models improve our knowledge about the basic mechanisms underlying COPD physiology, pathophysiology and treatment. Although these models are only able to mimic some of the features of the disease, they are valuable for further investigation of mechanisms involved in human COPD.

Methods

We searched the literature available in Google Scholar, PubMed and ScienceDirect databases for English articles published until November 2015. For this purpose, we used 5 keywords for COPD, 3 for animal models, 4 for exposure methods, 3 for pathophysiological changes and 3 for biomarkers. One hundred and fifty-one studies were considered eligible for inclusion in this review.

Results

According to the reviewed articles, animal models of COPD are mainly induced in mice, guinea pigs and rats. In most of the studies, this model was induced by exposure to cigarette smoke (CS), intra-tracheal lipopolysaccharide (LPS) and intranasal elastase. There were variations in time course and dose of inducers used in different studies. The main measured parameters were lung pathological data and lung inflammation (both inflammatory cells and inflammatory mediators) in most of the studies and tracheal responsiveness (TR) in only few studies.

Conclusion

The present review provides various methods used for induction of animal models of COPD, different animals used (mainly mice, guinea pigs and rats) and measured parameters. The information provided in this review is valuable for choosing appropriate animal, method of induction and selecting parameters to be measured in studies concerning COPD.
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Metadata
Title
Experimental animal models for COPD: a methodological review
Authors
Vahideh Ghorani
Mohammad Hossein Boskabady
Mohammad Reza Khazdair
Majid Kianmeher
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Tobacco Induced Diseases / Issue 1/2017
Electronic ISSN: 1617-9625
DOI
https://doi.org/10.1186/s12971-017-0130-2

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