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Clinical and Translational Allergy
Published in: Clinical and Translational Allergy 1/2011

Open Access 01-12-2011 | Research

Exhaled nitric oxide decreases after positive food-allergen challenge

Authors: Avigael H Benhamou, Alice Koehli, Isabelle Rochat, Demet Inci, Alexander Moeller, Philip Taramarcaz, Roger P Lauener, Philippe A Eigenmann

Published in: Clinical and Translational Allergy | Issue 1/2011

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Abstract

Background

Exhaled nitric oxide (FeNO) is a well described marker of airway inflammation in asthma and is also known to increase after chronic exposure to inhaled allergens. It is not known whether monitoring FeNO could be useful during food challenges to detect early or subclinical reactions.

Methods

Forty children aged 3 to 16 years undergoing an allergen-food challenge at two centres were prospectively recruited for this study. FeNO was assessed before and repeatedly after the food-challenge.

Results

Data were obtained from a total of 53 challenges (16 positive, 37 negative) and were compared between the two groups. Half of the patients with a positive food challenge exhibited clinical upper respiratory symptoms. The FeNO significantly decreased in 7 of 16 patients with a positive challenge test within 60 to 90 minutes after the first symptoms of an allergic reaction.

Conclusion

Our results show a significant decrease in FeNO after a positive food challenge suggesting involvement of the lower airways despite absence of clinical and functional changes of lower airways. Prospective blinded studies are needed to confirm these results.
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Metadata
Title
Exhaled nitric oxide decreases after positive food-allergen challenge
Authors
Avigael H Benhamou
Alice Koehli
Isabelle Rochat
Demet Inci
Alexander Moeller
Philip Taramarcaz
Roger P Lauener
Philippe A Eigenmann
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2011
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/2045-7022-1-14

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