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Clinical and Translational Allergy
Published in: Clinical and Translational Allergy 1/2011

Open Access 01-12-2011 | Review

Allergy as an epithelial barrier disease

Authors: Pirkko Mattila, Sakari Joenväärä, Jutta Renkonen, Sanna Toppila-Salmi, Risto Renkonen

Published in: Clinical and Translational Allergy | Issue 1/2011

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Abstract

The objective of this review is to focus on putative modified epithelial functions related to allergy. The dysregulation of the epithelial barrier might result in the allergen uptake, which could be the primary defect in the pathogenesis of allergic reaction. We review the literature of the role of respiratory epithelium as an active barrier, how allergens are transported through it and how it senses the hostile environmental allergens and other dangerous stimuli.
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Metadata
Title
Allergy as an epithelial barrier disease
Authors
Pirkko Mattila
Sakari Joenväärä
Jutta Renkonen
Sanna Toppila-Salmi
Risto Renkonen
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2011
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/2045-7022-1-5

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