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European Journal of Nuclear Medicine and Molecular Imaging

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01-05-2014 | Editorial Commentary

Evolving role of PET/CT with different tracers in the evaluation of pulmonary neuroendocrine tumours

Authors: Giorgio Treglia, Luca Giovanella, Filippo Lococo

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2014

Excerpt

Neuroendocrine tumours (NETs) of the lung arise from bronchial mucosal cells known as enterochromaffin cells or Kulchitsky cells, which are part of the diffuse neuroendocrine system. These tumours account for 20–25 % of all primary lung neoplasms [1]. The pathological spectrum of pulmonary NETs ranges from low- or intermediate-grade neoplasms, also known as typical or atypical bronchial carcinoids (BCs), respectively, to more aggressive tumours such as large cell and small cell lung cancer [1, 2]. In detail, the pathological distinction is substantially based on the microscopic morphology, the grade of differentiation, the mitotic rate and the presence of necrosis [2]. …

de Guevara AC, Burigana F, Nicolini A, Lugnani F. Neuroendocrine tumors of the lung: histological classification, diagnosis, traditional and new therapeutic approaches. Curr Med Chem 2013. doi:10.2174/0929867321666131129125953.

Rindi G, Klersy C, Inzani F, Fellegara G, Ampollini L, Ardizzoni A, et al. Grading the neuroendocrine tumors of the lung: an evidence-based proposal. Endocr Relat Cancer 2013;21:1–16.PubMedCrossRef

Benson RE, Rosado-de-Christenson ML, Martínez-Jiménez S, Kunin JR, Pettavel PP. Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics 2013;33:1631–49.PubMedCrossRef

Okoye CC, Jablons DM, Jahan TM, Kukreja J, Cardozo S, Yom SS. Divergent management strategies for typical versus atypical carcinoid tumors of the thoracic cavity. Am J Clin Oncol 2013. doi:10.1097/COC.0b013e31827a7f6d.PubMed

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Ambrosini V, Nicolini S, Caroli P, Nanni C, Massaro A, Marzola MC, et al. PET/CT imaging in different types of lung cancer: an overview. Eur J Radiol 2012;81:988–1001.PubMedCrossRef

Chong S, Lee KS, Kim BT, Choi JY, Yi CA, Chung MJ, et al. Integrated PET/CT of pulmonary neuroendocrine tumours: diagnostic and prognostic implications. AJR Am J Roentgenol 2007;188:1223–31.PubMedCrossRef

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10.

Treglia G, Castaldi P, Rindi G, Giordano A, Rufini V. Diagnostic performance of gallium-68 somatostatin receptor PET and PET/CT in patients with thoracic and gastroenteropancreatic neuroendocrine tumours: a meta-analysis. Endocrine 2012;42:80–7.PubMedCrossRef

11.

Rufini V, Treglia G, Montravers F, Giordano A. Diagnostic accuracy of [18F]DOPA PET and PET/CT in patients with neuroendocrine tumors: a meta-analysis. Clin Transl Imaging 2013;1:111–22.CrossRef

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Kayani I, Conry BG, Groves AM, Win T, Dickson J, Caplin M, et al. A comparison of 68Ga-DOTATATE and 18F-FDG PET/CT in pulmonary neuroendocrine tumors. J Nucl Med 2009;50:1927–32.PubMedCrossRef

13.

Jindal T, Kumar A, Venkitaraman B, Meena M, Kumar R, Malhotra A, et al. Evaluation of the role of [18F]FDG-PET/CT and [68Ga]DOTATOC-PET/CT in differentiating typical and atypical pulmonary carcinoids. Cancer Imaging 2011;11:70–5.PubMedCentralPubMedCrossRef

14.

Paci M, Lococo F, Rapicetta C, Roncali M, Cavazza A, Treglia G, et al. Synchronous bilateral bronchial carcinoid diagnosed with combined dual tracer (18F-FDG and 68Ga-DOTATOC) PET/CT scans. Rev Esp Med Nucl Imagen Mol 2013. doi:10.1016/j.remn.2013.08.007.

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Venkitaraman B, Karunanithi S, Kumar A, Khilnani GC, Kumar R. Role of 68Ga-DOTATOC PET/CT in initial evaluation of patients with suspected bronchopulmonary carcinoid. Eur J Nucl Med Mol Imaging. doi:10.1007/s00259-013-2659-5.

Title: Evolving role of PET/CT with different tracers in the evaluation of pulmonary neuroendocrine tumours
Authors: Giorgio Treglia
Luca Giovanella
Filippo Lococo
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2014
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2695-9

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Evolving role of PET/CT with different tracers in the evaluation of pulmonary neuroendocrine tumours

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