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European Radiology
Published in: European Radiology 5/2019

01-05-2019 | Magnetic Resonance

Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging

Authors: Jiule Ding, Zhaoyu Xing, Zhenxing Jiang, Hua Zhou, Jia Di, Jie Chen, Jianguo Qiu, Shengnan Yu, Liqiu Zou, Wei Xing

Published in: European Radiology | Issue 5/2019

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Abstract

Objective

To explore the value of texture analysis based on diffusion-weighted imaging (DWI), blood oxygen level–dependent MRI (BOLD), and susceptibility-weighted imaging (SWI) in evaluating renal dysfunction.

Methods

Seventy-two patients (mean age 53.72 ± 13.46 years) underwent MRI consisting of DWI, BOLD, and SWI. According to their estimated glomerular filtration rate (eGFR), the patients were classified into either severe renal function impairment (sRI, eGFR < 30 mL/min/1.73 m2), non-severe renal function impairment (non-sRI, eGFR ≥ 30 mL/min/1.73 m2, and < 80 mL/min/1.73 m2), or control (CG, eGFR ≥ 80 mL/min/1.73 m2) groups. Thirteen texture features were extracted and then were analyzed to select the most valuable for discerning the three groups with each imaging method. A ROC curve was performed to compare the capacities of the features to differentiate non-sRI from sRI or CG.

Results

Six features proved to be the most valuable for assessing renal dysfunction: 0.25QuantileDWI, 0.5QuantileDWI, HomogeneityDWI, EntropyBOLD, SkewnessSWI, and CorrelationSWI. Three features derived from DWI (0.25QuantileDWI, 0.5QuantileDWI, and HomogeneityDWI) were smaller in sRI than in non-sRI; EntropyBOLD and CorrelationSWI were smaller in non-sRI than in CG (p < 0.05). 0.25QuantileDWI, 0.5QuantileDWI, and HomogeneityDWI showed similar capacities for differentiating sRI from non-sRI. Similarly, EntropyBOLD and CorrelationSWI showed equal capacities for differentiating non-sRI from CG.

Conclusion

Texture analysis based on DWI, BOLD, and SWI can assist in assessing renal dysfunction, and texture features based on BOLD and SWI may be suitable for assessing renal dysfunction during early stages.

Key Points

• Texture analysis based on MRI techniques allowed for assessing renal dysfunction.
• Texture features based on BOLD and SWI, but not DWI, may be suitable for assessing renal function impairment during early stages.
• SWI exhibited a similar capacity to BOLD for assessing renal dysfunction.
Appendix
Available only for authorised users
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Metadata
Title
Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging
Authors
Jiule Ding
Zhaoyu Xing
Zhenxing Jiang
Hua Zhou
Jia Di
Jie Chen
Jianguo Qiu
Shengnan Yu
Liqiu Zou
Wei Xing
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5911-3

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