Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Journal of Pediatrics
Published in: European Journal of Pediatrics 1/2023

13-10-2022 | Etanercept | Research

Live-attenuated measles, mumps, and rubella booster vaccine in children diagnosed with rheumatic disease: A single-center study

Authors: Figen Çakmak, Özlem Akgün, Fatma Gül Demirkan, Ayşe Tanatar, Gülşah Kavrul Kayaalp, Gonca Keskindemirci, Vafa Guliyeva, Rukiye Eker Ömeroğlu, Emine Gülbin Gökçay, Nuray Aktay Ayaz

Published in: European Journal of Pediatrics | Issue 1/2023

Login to get access

Abstract

To evaluate the safety profile of measles, mumps and rubella (MMR) booster in children diagnosed with rheumatic diseases receiving biological agents. The study included retrospective safety data of children administered MMR booster dose receiving biologics or biologics with methotrexate. The files of 182 patients were accessed from the pediatric rheumatology biological therapy archive, and the vaccination status of these children was obtained by accessing electronic records. Of 182 patients, 14 patients were vaccinated with MMR booster dose. Thirteen of the patients were followed up with a diagnosis of juvenile idiopathic arthritis and one with colchicine-resistant familial Mediterranean fever. None of the patients had disease exacerbation after vaccination, and three patients had mild side effects consisting of rash, angioedema, joint pain, and fatigue.
    Conclusion: This study supports the data regarding evidence of the safety of MMR booster dose administration in children with rheumatic diseases receiving bDMARDs.
What is Known:
• MMR booster is avoided in immunocompromised pediatric patients receiving bDMARDs except in specific conditions.
What is New:
• The MMR booster dose may be safe in children with PedRD receiving bDMARDs or bDMARDs with MTX. These bullets can be added to the manuscript.
Literature
1.
Karadağ ŞG, Sönmez HE, Tanatar A, Çakmak F, Çakan M, Ayaz NA (2020) Profile of new referrals to a single pediatric rheumatology center in Turkey 40(2):313–321
2.
Minden K, Horneff G, Niewerth M, Seipelt E, Aringer M, Aries P, Foeldvari I, Haas JP, Klein A, Tatsis S, Tenbrock K (2019) Time of disease‐modifying antirheumatic drug start in juvenile idiopathic arthritis and the likelihood of a drug‐free remission in young adulthood 71(4):471–481
3.
Baris HE, Anderson E, Sozeri B, Dedeoglu FJCR (2018) Impact of biologics on disease course in systemic onset juvenile idiopathic arthritis 37(12):3263–3273
4.
Becker I, Horneff GJAc (2017) Research: Risk of serious infection in juvenile idiopathic arthritis patients associated with tumor necrosis factor inhibitors and disease activity in the German Biologics in Pediatric Rheumatology Registry 69(4):552–560
5.
Beukelman T, Xie F, Baddley JW, Chen L, Delzell E, Grijalva CG, Mannion ML, Patkar NM, Saag KG, Winthrop KLJA et al (2013) Brief report: incidence of selected opportunistic infections among children with juvenile idiopathic arthritis 65(5):1384–1389
6.
Aygun D, Sahin S, Adrovic A, Barut K, Cokugras H, Camcıoglu Y, Kasapcopur OJCr (2019) The frequency of infections in patients with juvenile idiopathic arthritis on biologic agents: 1-year prospective study 38(4):1025–1030
7.
Giancane G, Swart JF, Tzaribachev N, Rubio N, Cuttica R, Rumba-Rozenfelde I, Suwairi WMS, Lazar C, Uziel Y, Telcharova A (2019) Thu0666 serious/at least moderate infections in patients with juvenile idiopathic arthritis on synthetic and biologic drugs from the Pharmachild registry. BMJ Publishing Group Ltd, InCrossRef
8.
Ada GJNEJoM (2001) Vaccines and vaccination. 345(14):1042–1053
9.
Heijstek M, De Bruin LO, Bijl M, Borrow R, Van Der Klis F, Koné-Paut I, Fasth A, Minden K, Ravelli A, Abinun M (2011) EULAR recommendations for vaccination in paediatric patients with rheumatic diseases 70(10):1704–1712
10.
Furer V, Rondaan C, Heijstek MW, Agmon-Levin N, Van Assen S, Bijl M, Breedveld FC, D'amelio R, Dougados M, Kapetanovic MCJAotrd (2020) 2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases 79(1):39–52
11.
Borte S, Liebert U, Borte M, Sack U (2009) Efficacy of measles, mumps and rubella revaccination in children with juvenile idiopathic arthritis treated with methotrexate and etanercept 48(2):144–148
12.
Heijstek MW, Pileggi GC, Zonneveld-Huijssoon E, Armbrust W, Hoppenreijs EP, Uiterwaal CS, Kuis W, Wulffraat NM (2007) Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritis 66(10):1384–1387
13.
Heijstek MW, Kamphuis S, Armbrust W, Swart J, Gorter S, de Vries LD, Smits GP, van Gageldonk PG, Berbers GA, Wulffraat NMJJ (2013) Effects of the live attenuated measles-mumps-rubella booster vaccination on disease activity in patients with juvenile idiopathic arthritis: a randomized trial 309(23):2449–2456
14.
Bankowski Z, Bruppacher R, Crusius I, Gallagher J, Kremer G, Venulet JJGCfIOoMS (1999) Reporting adverse drug reactions
15.
Bizjak M, Blazina Š, Markelj G, Avčin T, Toplak NJC, Rheumatology E (2019) Vaccination coverage in children with rheumatic diseases 38(1):164–170
16.
Uziel Y, Moshe V, Onozo B, Kulcsár A, Tróbert-Sipos D, Akikusa JD, Pileggi GS, Maritsi D, Kasapcopur O, Rodrigues M (2020) Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: multicenter, retrospective data collection 38(9):2198–2201
17.
Heijstek MW, van Gageldonk PG, Berbers GA, Wulffraat NM (2012) Differences in persistence of measles, mumps, rubella, diphtheria and tetanus antibodies between children with rheumatic disease and healthy controls: a retrospective cross-sectional study 71(6):948–954
18.
Swart J, Giancane G, Horneff G, Magnusson B, Hofer M, Alexeeva Е, Panaviene V, Bader-Meunier B, Anton J, Nielsen S, De Benedetti F (2018) Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries 20(1):1–11
19.
Miyamoto M, Ono E, Barbosa C, Terreri M, Hilario M, Salomão R, Moraes-Pinto MD (2011) Vaccine antibodies and T-and B-cell interaction in juvenile systemic lupus erythematosus 20(7):736–744
Metadata
Title
Live-attenuated measles, mumps, and rubella booster vaccine in children diagnosed with rheumatic disease: A single-center study
Authors
Figen Çakmak
Özlem Akgün
Fatma Gül Demirkan
Ayşe Tanatar
Gülşah Kavrul Kayaalp
Gonca Keskindemirci
Vafa Guliyeva
Rukiye Eker Ömeroğlu
Emine Gülbin Gökçay
Nuray Aktay Ayaz
Publication date
13-10-2022
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 1/2023
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-022-04646-x

Other articles of this Issue 1/2023

European Journal of Pediatrics 1/2023 Go to the issue

Research

Efficacy of vitamin D supplementation on child and adolescent overweight/obesity: a systematic review and meta-analysis of randomized controlled trials

Research

Unnecessary radiation exposure during diagnostic radiography in infants in a neonatal intensive care unit: a retrospective cohort study

Research

Brainstem auditory pathway maturation in term neonates with congenital cytomegalovirus infection: a cohort study

Research

Is CMV PCR of inner ear fluid during cochlear implantation a way to diagnose CMV-related hearing loss?

Research

Fluid restriction in management of patent ductus arteriosus in Italy: a nationwide survey

Research

Prevalence and temporal dynamics of Cryptosporidium spp., Giardia duodenalis, and Blastocystis sp. among toddlers attending day-care centres in Spain. A prospective molecular-based longitudinal study