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Open Access 01-12-2022 | Esophagus Resection | Research

Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes

Authors: Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Takuya Kimoto, Shinsuke Nagasawa, Shou Watanabe, Shou Seri, Akito Asato, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Osamu Dohi, Takeshi Ishikawa, Hany Elsaleh, Kei Yamada

Published in: Radiation Oncology | Issue 1/2022

Abstract

Background

Esophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative endoscopic submucosal dissection (ESD). However, recent reports have also shown that ESD with adjuvant chemoradiotherapy (CRT) has promising results. This retrospective study aimed to elucidate the efficacy of CRT compared to surgery in patients with SESCC after noncurative ESD.

Methods

This study retrospectively compared the long-term outcomes of patients who received adjuvant treatment with surgery or CRT after noncurative ESD for SESCC.

Results

Data were collected from 60 patients who developed SESCC after noncurative ESD, 34 of whom received adjuvant chemoradiotherapy (CRT) and 26 underwent esophagectomy. The median follow-up periods were 46 and 56 months in the CRT and esophagectomy groups, respectively. The median patient age was significantly higher in the CRT group than in the esophagectomy group (69 vs. 65 years, p = 0.0054). CRT was completed in all patients, and the incidence of grade ≥ 3 nonhematologic adverse events was 6%. The overall and disease-free survival did not significantly differ between the two groups.

Conclusions

CRT following ESD seems a promising nonsurgical strategy for optimizing the selection of therapies for high-risk SESCC and warrant further investigation.

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Title: Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes
Authors: Gen Suzuki
Hideya Yamazaki
Norihiro Aibe
Koji Masui
Takuya Kimoto
Shinsuke Nagasawa
Shou Watanabe
Shou Seri
Akito Asato
Atsushi Shiozaki
Hitoshi Fujiwara
Hirotaka Konishi
Osamu Dohi
Takeshi Ishikawa
Hany Elsaleh
Kei Yamada
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Esophagus Resection
Esophagus Resection
Published in: Radiation Oncology / Issue 1/2022
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-022-02162-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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