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BMC Surgery
Published in: BMC Surgery 1/2020

01-12-2020 | Esophageal Cancer | Research article

Prognostic value of inflammatory markers for detecting anastomotic leakage after esophageal resection

Authors: Lukas F. Liesenfeld, Peter Sauer, Markus K. Diener, Ulf Hinz, Thomas Schmidt, Beat P. Müller-Stich, Thilo Hackert, Markus W. Büchler, Anja Schaible

Published in: BMC Surgery | Issue 1/2020

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Abstract

Background

Early diagnosis of anastomotic leakage (AL) after esophageal resection is crucial for the successful management of this complication. Inflammatory serological markers are indicators of complications during the postoperative course. The aim of the present study was to evaluate the prognostic value of routine inflammatory markers to predict anastomotic leakage after transthoracic esophageal resection.

Methods

Data from all consecutive patients undergoing transthoracic esophageal resection between January 2010 and December 2016 were analyzed from a prospective database. Besides clinicodemographic parameters, C-reactive protein, white blood cell count and albumin were analyzed and the Noble/Underwood (NUn) score was calculated to evaluate their predictive value for postoperative anastomotic leakage. Diagnostic accuracy was measured by sensitivity, specificity, and negative and positive predictive values using area under the receiver operator characteristics curve.

Results

Overall, 233 patients with transthoracic esophageal resection were analyzed, 30-day mortality in this group was 3.4%. 57 patients (24.5%) suffered from AL, 176 patients were in the AL negative group. We found significant differences in WBCC, CRP and NUn scores between patients with and without AL, but the analyzed markers did not show an independent relevant prognostic value. For CRP levels below 155 mg/dl from POD3 to POD 7 the negative predictive value for absence of AI was > 80%. Highest diagnostic accuracy was detected for CRP levels on 4th POD with a cut-off value of 145 mg/l reaching negative predictive value of 87%.

Conclusions

In contrast to their prognostic value in other surgical procedures, CRP, WBCC and NUn score cannot be recommended as independent markers for the prediction of anastomotic leakage after transthoracic esophageal resection. CRP is an accurate negative predictive marker and discrimination of AL and no-AL may be helpful for postoperative clinical management.
Trial registration The study was approved by the local ethical committee (S635-2013).
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Metadata
Title
Prognostic value of inflammatory markers for detecting anastomotic leakage after esophageal resection
Authors
Lukas F. Liesenfeld
Peter Sauer
Markus K. Diener
Ulf Hinz
Thomas Schmidt
Beat P. Müller-Stich
Thilo Hackert
Markus W. Büchler
Anja Schaible
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2020
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/s12893-020-00995-2

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