Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 11/2009

01-11-2009 | 2009 SSAT Plenary Presentation

National Trends in Esophageal Surgery—Are Outcomes as Good as We Believe?

Authors: Geoffrey Paul Kohn, Joseph Anton Galanko, Michael Owen Meyers, Richard Harry Feins, Timothy Michael Farrell

Published in: Journal of Gastrointestinal Surgery | Issue 11/2009

Login to get access

Abstract

Introduction

Positive volume–outcome relationships in esophagectomy have prompted support for regionalization of care; however, outcomes have not recently been analyzed. This study examines national trends in provision of esophagectomy and reassesses the volume–outcome relationship in light of changing practice patterns and training paradigms.

Methods

The Nationwide Inpatient Sample was queried from 1998 to 2006. Quantification of patients’ comorbidities was made using the Charlson Index. Using logistic regression modeling, institutions’ annual case volumes were correlated with risk-adjusted outcomes over time, as well as presence or absence of fellowship and residency training programs.

Results

A nationwide total of 57,676 esophagectomies were recorded. In-hospital unadjusted mortality fell from 12% to 7%. Adjusting for comorbidities, greater esophagectomy volume was associated with improvements in the incidence of most measured complications, though mortality increased once greater than 100 cases were performed. Hospitals supporting fellowship training or a surgical residency program did not have higher rates of mortality or total complications.

Conclusions

The current national mortality rate of 7% following esophagectomy is higher than is reported in most contemporary case series. A greater annual esophagectomy volume improves outcomes, but only up to a point. Current training paradigms are safe.
Literature
1.
go back to reference Trivers KF, Sabatino SA, Stewart SL. Trends in esophageal cancer incidence by histology, United States, 1998–2003. Int J Cancer 2008;123(6):1422–1428.CrossRefPubMed Trivers KF, Sabatino SA, Stewart SL. Trends in esophageal cancer incidence by histology, United States, 1998–2003. Int J Cancer 2008;123(6):1422–1428.CrossRefPubMed
2.
go back to reference Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK (eds). SEER Cancer Statistics Review, 1975–2006. Bethesda: National Cancer Institute. http://seer.cancer.gov/csr/1975_2006/, based on November 2008 SEER data submission, posted to the SEER web site, 2009. Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK (eds). SEER Cancer Statistics Review, 1975–2006. Bethesda: National Cancer Institute. http://​seer.​cancer.​gov/​csr/​1975_​2006/​, based on November 2008 SEER data submission, posted to the SEER web site, 2009.
3.
go back to reference U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2005 Incidence and Mortality Web-Based Report. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, 2009. Available at: www.cdc.gov/uscs. U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2005 Incidence and Mortality Web-Based Report. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, 2009. Available at: www.​cdc.​gov/​uscs.
4.
go back to reference Luft HS, Bunker JP, Enthoven AC et al. Should operations be regionalized? The empirical relation between surgical volume and mortality. N Engl J Med 1979;301(25):1364–3649.PubMed Luft HS, Bunker JP, Enthoven AC et al. Should operations be regionalized? The empirical relation between surgical volume and mortality. N Engl J Med 1979;301(25):1364–3649.PubMed
5.
go back to reference Miller JD, Jain MK, de Gara CJ et al. Effect of surgical experience on results of esophagectomy for esophageal carcinoma. J Surg Oncol 1997;65(1):20–21.CrossRefPubMed Miller JD, Jain MK, de Gara CJ et al. Effect of surgical experience on results of esophagectomy for esophageal carcinoma. J Surg Oncol 1997;65(1):20–21.CrossRefPubMed
6.
go back to reference Gordon TA, Bowman HM, Tielsch JM et al. Statewide regionalization of pancreaticoduodenectomy and its effect on in-hospital mortality. Ann Surg 1998;228(1):71–78.CrossRefPubMed Gordon TA, Bowman HM, Tielsch JM et al. Statewide regionalization of pancreaticoduodenectomy and its effect on in-hospital mortality. Ann Surg 1998;228(1):71–78.CrossRefPubMed
7.
go back to reference Birkmeyer JD, Finlayson SR, Tosteson AN et al. Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy. Surgery 1999;125(3):250–256.PubMed Birkmeyer JD, Finlayson SR, Tosteson AN et al. Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy. Surgery 1999;125(3):250–256.PubMed
8.
go back to reference Pal N, Axisa B, Yusof S et al. Volume and outcome for major upper GI surgery in England. J Gastrointest Surg 2008;12(2):353–357.CrossRefPubMed Pal N, Axisa B, Yusof S et al. Volume and outcome for major upper GI surgery in England. J Gastrointest Surg 2008;12(2):353–357.CrossRefPubMed
9.
go back to reference Alderson D. Scottish Intercollegiate Guidelines Network (SIGN) 87—the management of oesophageal and gastric cancer. Clin Oncol (R Coll Radiol) 2008;20(7):530–531. Alderson D. Scottish Intercollegiate Guidelines Network (SIGN) 87—the management of oesophageal and gastric cancer. Clin Oncol (R Coll Radiol) 2008;20(7):530–531.
10.
go back to reference National Comprehensive Cancer Network. Clinical practice guidelines in oncology: esophageal cancer. Fort Washington: National Comprehensive Cancer Network, 2009. National Comprehensive Cancer Network. Clinical practice guidelines in oncology: esophageal cancer. Fort Washington: National Comprehensive Cancer Network, 2009.
11.
go back to reference The Leapfrog Group. Evidence-Based Hospital Referral (EBHR) and Common Acute Conditions (CACs) Coding Specifications for Volume v5.1.1. Washington, DC: The Leapfrog Group, 2008. The Leapfrog Group. Evidence-Based Hospital Referral (EBHR) and Common Acute Conditions (CACs) Coding Specifications for Volume v5.1.1. Washington, DC: The Leapfrog Group, 2008.
13.
go back to reference Birkmeyer JD, Dimick JB. Potential benefits of the new Leapfrog standards: effect of process and outcomes measures. Surgery 2004;135(6):569–575.CrossRefPubMed Birkmeyer JD, Dimick JB. Potential benefits of the new Leapfrog standards: effect of process and outcomes measures. Surgery 2004;135(6):569–575.CrossRefPubMed
14.
go back to reference Allareddy V, Konety BR. Specificity of procedure volume and in-hospital mortality association. Ann Surg 2007;246(1):135–139.CrossRefPubMed Allareddy V, Konety BR. Specificity of procedure volume and in-hospital mortality association. Ann Surg 2007;246(1):135–139.CrossRefPubMed
15.
go back to reference Christian CK, Gustafson ML, Betensky RA et al. The Leapfrog volume criteria may fall short in identifying high-quality surgical centers. Ann Surg 2003;238(4):447–455. discussion 455–7.PubMed Christian CK, Gustafson ML, Betensky RA et al. The Leapfrog volume criteria may fall short in identifying high-quality surgical centers. Ann Surg 2003;238(4):447–455. discussion 455–7.PubMed
16.
go back to reference van Lanschot JJ, Hulscher JB, Buskens CJ et al. Hospital volume and hospital mortality for esophagectomy. Cancer 2001;91(8):1574–1578.CrossRefPubMed van Lanschot JJ, Hulscher JB, Buskens CJ et al. Hospital volume and hospital mortality for esophagectomy. Cancer 2001;91(8):1574–1578.CrossRefPubMed
17.
go back to reference Dimick JB, Cowan JA Jr., Ailawadi G et al. National variation in operative mortality rates for esophageal resection and the need for quality improvement. Arch Surg 2003;138(12):1305–1309.CrossRefPubMed Dimick JB, Cowan JA Jr., Ailawadi G et al. National variation in operative mortality rates for esophageal resection and the need for quality improvement. Arch Surg 2003;138(12):1305–1309.CrossRefPubMed
18.
go back to reference Birkmeyer JD, Siewers AE, Finlayson EV et al. Hospital volume and surgical mortality in the United States. N Engl J Med 2002;346(15):1128–1137.CrossRefPubMed Birkmeyer JD, Siewers AE, Finlayson EV et al. Hospital volume and surgical mortality in the United States. N Engl J Med 2002;346(15):1128–1137.CrossRefPubMed
19.
go back to reference Forshaw MJ, Gossage JA, Stephens J et al. Centralisation of oesophagogastric cancer services: can specialist units deliver? Ann R Coll Surg Engl 2006;88(6):566–570.CrossRefPubMed Forshaw MJ, Gossage JA, Stephens J et al. Centralisation of oesophagogastric cancer services: can specialist units deliver? Ann R Coll Surg Engl 2006;88(6):566–570.CrossRefPubMed
20.
go back to reference Migliore M, Choong CK, Lim E et al. A surgeon’s case volume of oesophagectomy for cancer strongly influences the operative mortality rate. Eur J Cardiothorac Surg 2007;32(2):375–380.CrossRefPubMed Migliore M, Choong CK, Lim E et al. A surgeon’s case volume of oesophagectomy for cancer strongly influences the operative mortality rate. Eur J Cardiothorac Surg 2007;32(2):375–380.CrossRefPubMed
21.
go back to reference Yannopoulos P, Theodoridis P, Manes K. Esophagectomy without thoracotomy: 25 years of experience over 750 patients. Langenbecks Arch Surg 2009;394:611–616.CrossRefPubMed Yannopoulos P, Theodoridis P, Manes K. Esophagectomy without thoracotomy: 25 years of experience over 750 patients. Langenbecks Arch Surg 2009;394:611–616.CrossRefPubMed
22.
go back to reference Decker G, Coosemans W, De Leyn P et al. Minimally invasive esophagectomy for cancer. Eur J Cardiothorac Surg 2009;35(1):13–20. discussion 20–1.CrossRefPubMed Decker G, Coosemans W, De Leyn P et al. Minimally invasive esophagectomy for cancer. Eur J Cardiothorac Surg 2009;35(1):13–20. discussion 20–1.CrossRefPubMed
23.
go back to reference Collins G, Johnson E, Kroshus T et al. Experience with minimally invasive esophagectomy. Surg Endosc 2006;20(2):298–301.CrossRefPubMed Collins G, Johnson E, Kroshus T et al. Experience with minimally invasive esophagectomy. Surg Endosc 2006;20(2):298–301.CrossRefPubMed
24.
go back to reference Law S, Wong KH, Kwok KF et al. Predictive factors for postoperative pulmonary complications and mortality after esophagectomy for cancer. Ann Surg 2004;240(5):791–800.CrossRefPubMed Law S, Wong KH, Kwok KF et al. Predictive factors for postoperative pulmonary complications and mortality after esophagectomy for cancer. Ann Surg 2004;240(5):791–800.CrossRefPubMed
25.
go back to reference Metzger R, Bollschweiler E, Vallbohmer D et al. High volume centers for esophagectomy: what is the number needed to achieve low postoperative mortality? Dis Esophagus 2004;17(4):310–314.CrossRefPubMed Metzger R, Bollschweiler E, Vallbohmer D et al. High volume centers for esophagectomy: what is the number needed to achieve low postoperative mortality? Dis Esophagus 2004;17(4):310–314.CrossRefPubMed
26.
go back to reference Begg CB, Cramer LD, Hoskins WJ et al. Impact of hospital volume on operative mortality for major cancer surgery. JAMA 1998;280(20):1747–1751.CrossRefPubMed Begg CB, Cramer LD, Hoskins WJ et al. Impact of hospital volume on operative mortality for major cancer surgery. JAMA 1998;280(20):1747–1751.CrossRefPubMed
27.
go back to reference Dimick JB, Cattaneo SM, Lipsett PA et al. Hospital volume is related to clinical and economic outcomes of esophageal resection in Maryland. Ann Thorac Surg 2001;72(2):334–339. discussion 339–41.CrossRefPubMed Dimick JB, Cattaneo SM, Lipsett PA et al. Hospital volume is related to clinical and economic outcomes of esophageal resection in Maryland. Ann Thorac Surg 2001;72(2):334–339. discussion 339–41.CrossRefPubMed
28.
go back to reference Patti MG, Corvera CU, Glasgow RE et al. A hospital’s annual rate of esophagectomy influences the operative mortality rate. J Gastrointest Surg 1998;2(2):186–192.CrossRefPubMed Patti MG, Corvera CU, Glasgow RE et al. A hospital’s annual rate of esophagectomy influences the operative mortality rate. J Gastrointest Surg 1998;2(2):186–192.CrossRefPubMed
29.
go back to reference Kuo EY, Chang Y, Wright CD. Impact of hospital volume on clinical and economic outcomes for esophagectomy. Ann Thorac Surg 2001;72(4):1118–11124.CrossRefPubMed Kuo EY, Chang Y, Wright CD. Impact of hospital volume on clinical and economic outcomes for esophagectomy. Ann Thorac Surg 2001;72(4):1118–11124.CrossRefPubMed
30.
go back to reference Dimick JB, Wainess RM, Upchurch GR Jr et al. National trends in outcomes for esophageal resection. Ann Thorac Surg 2005;79(1):212–216. discussion 217–8.CrossRefPubMed Dimick JB, Wainess RM, Upchurch GR Jr et al. National trends in outcomes for esophageal resection. Ann Thorac Surg 2005;79(1):212–216. discussion 217–8.CrossRefPubMed
31.
go back to reference Rohatgi A, Sutcliffe R, Forshaw MJ et al. Training in oesophageal surgery—the gold standard: a prospective study. Int J Surg 2008;6(3):230–233.CrossRefPubMed Rohatgi A, Sutcliffe R, Forshaw MJ et al. Training in oesophageal surgery—the gold standard: a prospective study. Int J Surg 2008;6(3):230–233.CrossRefPubMed
38.
go back to reference Healthcare Cost and Utilization Project (HCUP). 1998–2006 [database online]. Insert City of Publication Here see notes: Agency for Healthcare Research and Quality, Rockville, MD. Healthcare Cost and Utilization Project (HCUP). 1998–2006 [database online]. Insert City of Publication Here see notes: Agency for Healthcare Research and Quality, Rockville, MD.
39.
go back to reference Santry HP, Gillen DL, Lauderdale DS. Trends in bariatric surgical procedures. JAMA 2005;294(15):1909–1917.CrossRefPubMed Santry HP, Gillen DL, Lauderdale DS. Trends in bariatric surgical procedures. JAMA 2005;294(15):1909–1917.CrossRefPubMed
40.
go back to reference Scottish Intercollegiate Guidelines Network. Scottish Intercollegiate Guidelines Network (SIGN) 87—the management of oesophageal and gastric cancer: A national clinical guideline. Edinburgh: SIGN, 2006. Scottish Intercollegiate Guidelines Network. Scottish Intercollegiate Guidelines Network (SIGN) 87—the management of oesophageal and gastric cancer: A national clinical guideline. Edinburgh: SIGN, 2006.
41.
go back to reference Kohn GP, Galanko JA, Overby DW et al. Volume–outcome relationships and other influences of outcome in bariatric surgery. Surg Endosc 2009;23(S1):149. Kohn GP, Galanko JA, Overby DW et al. Volume–outcome relationships and other influences of outcome in bariatric surgery. Surg Endosc 2009;23(S1):149.
42.
go back to reference Urbach DR, Austin PC. Conventional models overestimate the statistical significance of volume–outcome associations, compared with multilevel models. J Clin Epidemiol 2005;58(4):391–400.CrossRefPubMed Urbach DR, Austin PC. Conventional models overestimate the statistical significance of volume–outcome associations, compared with multilevel models. J Clin Epidemiol 2005;58(4):391–400.CrossRefPubMed
43.
go back to reference Birkmeyer JD, Finlayson EV, Birkmeyer CM. Volume standards for high-risk surgical procedures: potential benefits of the Leapfrog initiative. Surgery 2001;130(3):415–422.CrossRefPubMed Birkmeyer JD, Finlayson EV, Birkmeyer CM. Volume standards for high-risk surgical procedures: potential benefits of the Leapfrog initiative. Surgery 2001;130(3):415–422.CrossRefPubMed
44.
go back to reference Muller JM, Erasmi H, Stelzner M et al. Surgical therapy of oesophageal carcinoma. Br J Surg 1990;77(8):845–857.CrossRefPubMed Muller JM, Erasmi H, Stelzner M et al. Surgical therapy of oesophageal carcinoma. Br J Surg 1990;77(8):845–857.CrossRefPubMed
45.
go back to reference Whooley BP, Law S, Murthy SC et al. Analysis of reduced death and complication rates after esophageal resection. Ann Surg 2001;233(3):338–344.CrossRefPubMed Whooley BP, Law S, Murthy SC et al. Analysis of reduced death and complication rates after esophageal resection. Ann Surg 2001;233(3):338–344.CrossRefPubMed
46.
go back to reference Gananadha S, Hazebroek EJ, Leibman S et al. The utility of FDG-PET in the preoperative staging of esophageal cancer. Dis Esophagus 2008;21(5):389–394.CrossRefPubMed Gananadha S, Hazebroek EJ, Leibman S et al. The utility of FDG-PET in the preoperative staging of esophageal cancer. Dis Esophagus 2008;21(5):389–394.CrossRefPubMed
47.
go back to reference Tomaszek S, Cassivi SD. Esophagectomy for the treatment of esophageal cancer. Gastroenterol Clin North Am 2009;38(1):169–181. x.CrossRefPubMed Tomaszek S, Cassivi SD. Esophagectomy for the treatment of esophageal cancer. Gastroenterol Clin North Am 2009;38(1):169–181. x.CrossRefPubMed
48.
go back to reference Wouters MW, Wijnhoven BP, Karim-Kos HE et al. High-volume versus low-volume for esophageal resections for cancer: the essential role of case-mix adjustments based on clinical data. Ann Surg Oncol 2008;15(1):80–87.CrossRefPubMed Wouters MW, Wijnhoven BP, Karim-Kos HE et al. High-volume versus low-volume for esophageal resections for cancer: the essential role of case-mix adjustments based on clinical data. Ann Surg Oncol 2008;15(1):80–87.CrossRefPubMed
49.
go back to reference Rodgers M, Jobe BA, O’Rourke RW et al. Case volume as a predictor of inpatient mortality after esophagectomy. Arch Surg 2007;142(9):829–839.CrossRefPubMed Rodgers M, Jobe BA, O’Rourke RW et al. Case volume as a predictor of inpatient mortality after esophagectomy. Arch Surg 2007;142(9):829–839.CrossRefPubMed
50.
go back to reference Leigh Y, Goldacre M, McCulloch P. Surgical specialty, surgical unit volume and mortality after oesophageal cancer surgery. Eur J Surg Oncol 2009;35:820–825.PubMed Leigh Y, Goldacre M, McCulloch P. Surgical specialty, surgical unit volume and mortality after oesophageal cancer surgery. Eur J Surg Oncol 2009;35:820–825.PubMed
51.
go back to reference Quan H, Li B, Saunders LD et al. Assessing validity of ICD-9-CM and ICD-10 administrative data in recording clinical conditions in a unique dually coded database. Health Serv Res 2008;43(4):1424–1441.CrossRefPubMed Quan H, Li B, Saunders LD et al. Assessing validity of ICD-9-CM and ICD-10 administrative data in recording clinical conditions in a unique dually coded database. Health Serv Res 2008;43(4):1424–1441.CrossRefPubMed
52.
go back to reference Lacasse Y, Montori VM, Maltais F. Administrative database: validity of recording vs. validity of diagnosis. J Clin Epidemiol 2006;59(1):104. author reply 104–5.CrossRefPubMed Lacasse Y, Montori VM, Maltais F. Administrative database: validity of recording vs. validity of diagnosis. J Clin Epidemiol 2006;59(1):104. author reply 104–5.CrossRefPubMed
53.
go back to reference Kohn GP, Galanko JA, Overby DW et al. Recent trends in bariatric surgery case volume in the United States. Surgery 2009;146(2):375–380.CrossRefPubMed Kohn GP, Galanko JA, Overby DW et al. Recent trends in bariatric surgery case volume in the United States. Surgery 2009;146(2):375–380.CrossRefPubMed
Metadata
Title
National Trends in Esophageal Surgery—Are Outcomes as Good as We Believe?
Authors
Geoffrey Paul Kohn
Joseph Anton Galanko
Michael Owen Meyers
Richard Harry Feins
Timothy Michael Farrell
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 11/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-009-1008-2

Other articles of this Issue 11/2009

Journal of Gastrointestinal Surgery 11/2009 Go to the issue