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01-01-2010 | Review Article

ES, iPS, MSC, and AFS cells. Stem cells exploitation for Pediatric Surgery: current research and perspective

Authors: Michela Pozzobon, Marco Ghionzoli, Paolo De Coppi

Published in: Pediatric Surgery International | Issue 1/2010

Abstract

Despite the advancements that have been made in treating infants with congenital malformations, these still represent a major cause of disease and death during the first years of life and childhood. Regeneration of natural tissue from living cells to restore damaged tissues and organs is the main purpose of regenerative medicine. This relatively new field has emerged by the combination of tissue engineering and stem cell transplantation as a possible strategy for the replacement of damaged organs or tissues. This review would like to offer an insight on the latest evolution of stem cells with a glance at their possible application for regenerative medicine, particularly in the Paediatric Surgery field.

Placzek MR, Chung IM, Macedo HM, Ismail S, Mortera Blanco T, Lim M, Cha JM, Fauzi I, Kang Y, Yeo DC, Ma CY, Polak JM, Panoskaltsis N, Mantalaris A (2009) Stem cell bioprocessing: fundamentals and principles. J R Soc Interface 6(32):209–232CrossRefPubMed

Safinia L, Datan N, Höhse M, Mantalaris A, Bismarck A (2005) Towards a methodology for the effective surface modification of porous polymer scaffolds. Biomaterials 26(36):7537–7547CrossRefPubMed

Carraro A, Hsu WM, Kulig KM, Cheung WS, Miller ML, Weinberg EJ, Swart EF, Kaazempur-Mofrad M, Borenstein JT, Vacanti JP, Neville C (2008) In vitro analysis of a hepatic device with intrinsic microvascular-based channels. Biomed Microdevices 10(6):795–805CrossRefPubMed

Nagy RD, Tsai BM, Wang M et al (2005) Stem cell transplantation as a therapeutic approach to organ failure. J Surg Res 129(1):152–160CrossRefPubMed

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M et al (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41–49CrossRefPubMed

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143CrossRefPubMed

McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA (2002) Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci USA 99:1341–1346CrossRefPubMed

Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM (2002) Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 109(10):1291–1302PubMed

LaBarge MA, Blau HM (2002) Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. Cell 111:589–601CrossRefPubMed

10.

Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F (1998) Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279(5356):1528–1530 (erratum in: Science 1998 Aug 14;281(5379):923)CrossRefPubMed

11.

Shamblott MJ, Axelman J, Littlefield JW, Blumenthal PD, Huggins GR, Cui Y, Cheng L, Gearhart JD (2001) Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. PNAS 98(1):113–118CrossRefPubMed

12.

Kofidis T, de Bruin JL, Hoyt G, Ho Y, Tanaka M, Yamane T, Lebl DR, Swijnenburg RJ, Chang CP, Quertermous T, Robbins RC (2005) Myocardial restoration with embryonic stem cell bioartificial tissue transplantation. J Heart Lung Transplant 24(6):737–744CrossRefPubMed

13.

Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Sweier JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282(5391):1145CrossRefPubMed

14.

Markel TA, Crisostomo PR, Lahm T, Novotny NM, Rescorla FJ, Tector J, Meldrum DR (2008) Stem cells as a potential future treatment of pediatric intestinal disorders. J Pediatr Surg 43(11):1953–1963CrossRefPubMed

15.

De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A (2007) Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 25(1):100–106CrossRefPubMed

16.

Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676CrossRefPubMed

17.

Odorico JS, Kaufman DS, Thomson JA (2001) Multilineage differentiation from human embryonic stem cell lines. Stem Cells 19(3):193–204CrossRefPubMed

18.

Amit M, Shariki C, Margulets V et al (2004) Feeder layer and serum-free culture of human embryonic stem cells. Biol Reprod 70(3):837–845CrossRefPubMed

19.

Richards M, Fong CY, Chan WK et al (2002) Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells. Nat Biotechnol 20(9):933–936CrossRefPubMed

20.

Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154–156CrossRefPubMed

21.

Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634–7638CrossRefPubMed

22.

Fong H, Hohenstein KA, Donovan PJ (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26(8):1931–1938 (Epub 2008 Apr 3)CrossRefPubMed

23.

Lott JP, Savulescu J (2007) Towards a global human embryonic stem cell bank. Am J Bioeth 7(8):37–44CrossRefPubMed

24.

Hipp J, Atala A (2008) Sources of stem cells for regenerative medicine. Stem Cell Rev 4(1):3–11 ReviewCrossRefPubMed

25.

Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R (2006) Human embryonic stem cell lines derived from single blastomeres. Nature 444(7118):481–485 (epub 2006 Aug 23. Erratum in: Nature. 2006 Nov 23;444(7118):512. Nature. 2007 Mar 15;446(7133):342)CrossRefPubMed

26.

Chung Y, Klimanskaya I, Becker S, Marh J, Lu SJ, Johnson J, Meisner L, Lanza R (2006) Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature 439(7073):216–219 (epub 2005 Oct 16)CrossRefPubMed

27.

Deb KD, Sarda K (2008) Human embryonic stem cells: preclinical perspectives. J Transl Med 6:7CrossRefPubMed

28.

Briggs R, King TJ (1952) The transplantation of living nuclei from blastula cells into enucleated frog’s eggs. Proc Natl Acad Sci USA 38:455–463CrossRefPubMed

29.

Gurdon JB, Laskey RA (1970) The transplantation of nuclei from single cultured cells into enucleate frogs’eggs. J Embryol Exp Morphol 24(2):227–248PubMed

30.

Campbell KH, McWhir J, Ritchie WA, Wilmut I (1996) Sheep cloned by nuclear transfer from a cultured cell line. Nature 380(6569):64–66CrossRefPubMed

31.

Franco D, Moreno N, Ruiz-Lozano P (2007) Non-resident stem cell populations in regenerative cardiac medicine. Cell Mol Life Sci 64(6):683–691CrossRefPubMed

32.

Dalgetty DM, Medine CN, Iredale JP, Hay DC (2009) Progress and future challenges in stem cell-derived liver technologies. Am J Physiol Gastrointest Liver Physiol 297(2):G241–G248CrossRefPubMed

33.

Anglani F, Forino M, Del Prete D, Tosetto E, Torregrossa R, D’Angelo A (2004) In search of adult renal stem cells. J Cell Mol Med 8(4):474–487CrossRefPubMed

34.

Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ (2008) Human embryonic stem cell derivation from poor-quality embryos. Nat Biotechnol 26(2):212–214 (epub 2008 Jan 27)CrossRefPubMed

35.

Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448(7151):318–324 (epub 2007 Jun 6)CrossRefPubMed

36.

Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedlinger K (2007) Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1(1):55–70CrossRefPubMed

37.

Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858):1917–1920CrossRefPubMed

38.

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861–872CrossRefPubMed

39.

Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448(7151):313–317CrossRefPubMed

40.

Meissner A, Wernig M, Jaenisch R (2007) Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 25(10):1177–1181CrossRefPubMed

41.

Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S (2008) Generation of mouse induced pluripotent stem cells without viral vectors. Science 322(5903):949–953CrossRefPubMed

42.

Yu J, Thomson JA (2008) Pluripotent stem cell lines. Genes Dev 22(15):1987–1997 ReviewCrossRefPubMed

43.

Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R (2009) Parkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136(5):964–977CrossRefPubMed

44.

Friedenstein AJ, Kulagina NN, Panasuk AF, Rudakowa SF (1974) Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol 2:83–92PubMed

45.

Campagnoli C, Roberts IAG (2001) Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 98:2396–2402CrossRefPubMed

46.

In ‘t Anker PS, Scherjon SA (2003) Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 102:1548–1549CrossRefPubMed

47.

Tsai MS, Lee JL (2004) Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod 19:1450–1456CrossRefPubMed

48.

Fan CG, Thang FW, Zhang Q (2005) Characterization and neural differentiation of fetal lung mesenchymal stem cells. Cell Transplant 14:311–321CrossRefPubMed

49.

Waddington RJ, Youde SJ, Lee CP, Sloan AJ (2009) Isolation of distinct progenitor stem cell populations from dental pulp. Cells Tissues Organs 189(1–4):268–274 (epub 2008 Aug 14)CrossRefPubMed

50.

Eyckmans J, Luyten FP (2006) Species specificity of ectopic bone formation using periosteum-derived mesenchymal progenitor cells. Tissue Eng 12(8):2203–2213CrossRefPubMed

51.

Erices A, Conget P (2000) Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 109:235–242CrossRefPubMed

52.

Romanov YA, Svintsitskaya VA (2003) Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 21:105–110CrossRefPubMed

53.

Igura K, Takahashi K, Mitsuru A, Yamaguchi S (2004) Isolation and characterization of mesenchymal progenitor cells from chorionic villi of human placenta. Cytotherapy 6:543–553CrossRefPubMed

54.

Perin L, Sedrakyan S, Da Sacco S, De Filippo R (2008) Characterization of human amniotic fluid stem cells and their pluripotential capability. Methods Cell Biol 86:85–99CrossRefPubMed

55.

Horwitz EM, Blanc KL (2005) Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 7:393–395CrossRefPubMed

56.

Kern S, Eichler H (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294–1301CrossRefPubMed

57.

Le Blanc K (2003) Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 5(6):485–489CrossRefPubMed

58.

Karlsson H, Samarasinghe S, Ball LM, Sundberg B, Lankester AC, Dazzi F, Uzunel M, Rao K, Veys P, Le Blanc K, Ringdén O, Amrolia PJ (2008) Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses. Blood 112(3):532–541 (epub 2008 Apr 28)CrossRefPubMed

59.

Crisostomo PR, Markel TA, Wang Y, Meldrum DR (2008) Surgically relevant aspects of stem cell paracrine effects. Surgery 143(5):577–581 (epub 2008 Jan 30)CrossRefPubMed

60.

Takeda Y, Mori T, Imabayashi H, Kiyono T, Gojo S, Miyoshi S, Hida N, Ita M, Segawa K, Ogawa S, Sakamoto M, Nakamura S, Umezawa A (2004) Can the life span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation? J Gene Med 6:833–845CrossRefPubMed

61.

Ksiazek K (2009) A comprehensive review on mesenchymal stem cell growth and senescence. Rejuvenation Res 12(2):105–116CrossRefPubMed

62.

Terai M, Uyama T, Sugiki T, Li XK, Umezawa A, Kiyono T (2005) Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol Biol Cell 16:1491–1499CrossRefPubMed

63.

Takeuchi M, Takeuchi K, Kohara A, Satoh M, Shioda S, Ozawa Y, Ohtani A, Morita K, Hirano T, Terai M, Umezawa A, Mizusawa H (2007) Chromosomal instability in human mesenchymal stem cells immortalized with human papilloma virus E6, E7, and hTERT genes. In Vitro Cell Dev Biol Anim 43(3–4):129–138 (epub 2007 May 21)CrossRefPubMed

64.

Pelagiadis I, Dimitriou H, Kalmanti M (2008) Biologic characteristics of mesenchymal stromal cells and their clinical applications in pediatric patients. J Pediatr Hematol Oncol 30(4):301–309CrossRefPubMed

65.

Sanchez-Ramos J, Song S, Cardozo-Pelaez F et al (2000) Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 164:247–256CrossRefPubMed

66.

Hong SH, Gang EJ, Jeong JA et al (2005) In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 330:1153–1161CrossRefPubMed

67.

Sugaya K (2003) Potential use of stem cells in neuroreplacement therapies for neurodegenerative diseases. Int Rev Cytol 228:1–30CrossRefPubMed

68.

Dimmeler S, Zeiher AM (2009) Cell therapy of acute myocardial infarction: open questions. Cardiology 113(3):155–160 (epub 2008 Dec 22)CrossRefPubMed

69.

Koc ON, Gerson SC, Lazarus HM et al (2002) Allogenic mesenchymal stem cell infusion for treatment of metachromatic leucodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 30:215–222CrossRefPubMed

70.

Whyte MP, Kurtzberg J, McAlister WH et al (2003) Marrow cell transplantation for infantile hypophosphatasia. J Bone Miner Res 18:624–636CrossRefPubMed

71.

Horwitz EM, Prockop DJ, Fitzpatrick LA et al (1999) Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5:309CrossRefPubMed

72.

Horwitz EM, Gordon PL, Koo WK et al (2002) Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA 99:8932CrossRefPubMed

73.

Le Blanc K, Gotherstrom C, Ringden O et al (2005) Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta. Transplantation 79:1607–1614CrossRefPubMed

74.

Mazzini L, Mareschi K, Ferrero I, Vassallo E, Oliveri G, Nasuelli N, Oggioni G, Testa L, Fagioli F (2008) Stem cell treatment in amyotrophic lateral sclerosis. J Neurol Sci 265(1):78–83CrossRefPubMed

75.

Burt RK, Loh Y, Pearce W, Beohar N, Barr WG, Craig R, Wen Y, Rapp JA, Kessler J (2008) Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases. JAMA 299(8):925–936CrossRefPubMed

76.

Fuchs JR, Hannouche D, Terada S et al (2005) Cartilage engineering from ovine umbilical cord blood mesenchymal progenitor cells. Stem Cells 23:958–964CrossRefPubMed

77.

Kunisaki SM, Freedman DA, Fauza DO (2006) Fetal tracheal reconstruction with cartilaginous grafts engineered from mesenchymal amniocytes. J Pediatr Surg 41:675–682CrossRefPubMed

78.

Zsebo KM et al (1990) Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63:213–224CrossRefPubMed

79.

Pan GJ, Chang ZY, Scholer HR, Pei D (2002) Stem cell pluripotency and transcription factor Oct4. Cell Res 12:321–329CrossRefPubMed

80.

Takahashi K, Okita K, Nakagawa M, Yamanaka S (2007) Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2(12):3081–3089CrossRefPubMed

81.

Park IH, Lerou PH, Zhao R, Huo H, Daley GQ (2008) Generation of human-induced pluripotent stem cells. Nat Protoc 3(7):1180–1186CrossRefPubMed

82.

Macchiarini P, Jungebluth P, Go T, Asnaghi MA, LE Rees, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP, Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA (2008) Clinical transplantation of a tissue-engineered airway. Lancet 372(9655):2023–2030 (epub 2008 Nov 18)CrossRefPubMed

83.

Thapar N (2009) New frontiers in the treatment of Hirschsprung disease. J Pediatr Gastroenterol Nutr 48(Suppl 2):S92–S94CrossRefPubMed

84.

Zani A, Cananzi M, Eaton S, Pierro A, De Coppi P (2009) Stem cells as a potential treatment of necrotizing enterocolitis. J Pediatr Surg 44(3):659–660 Comment on: J Pediatr Surg. 2008 Nov;43(11):1953–63CrossRefPubMed

85.

Javaid-Ur-Rehman, Waseem T (2008) Intestinal tissue engineering: where do we stand? Surg Today 38:484–486

86.

Grikscheit TC, Siddique A, Ochoa ER, Srinivasan A, Alsberg E, Hodin RA, Vacanti JP (2004) Tissue-engineered small intestine improves recovery after massive small bowel resection. Ann Surg 240(5):748–754CrossRefPubMed

87.

Ware CB, Nelson AM, Blau CA (2006) A comparison of NIH-approved human ESC lines. Stem Cells 24(12):2677–2684CrossRefPubMed

Title: ES, iPS, MSC, and AFS cells. Stem cells exploitation for Pediatric Surgery: current research and perspective
Authors: Michela Pozzobon
Marco Ghionzoli
Paolo De Coppi
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 1/2010
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-009-2478-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

ES, iPS, MSC, and AFS cells. Stem cells exploitation for Pediatric Surgery: current research and perspective

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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