Skip to main content
Top
Published in: Abdominal Radiology 7/2020

01-07-2020 | Erectile Dysfunction | Special Section: Male pelvis

Utility of dynamic MRA in the evaluation of male erectile dysfunction

Authors: Alexandra Roudenko, Rand N. Wilcox Vanden Berg, Christopher Song, Martin R. Prince, Darius A. Paduch, Daniel Margolis

Published in: Abdominal Radiology | Issue 7/2020

Login to get access

Abstract

Purpose

To assess the efficacy of time-resolved MR angiography (MRA) in evaluating penile vasculature in patients with clinically suspected vascular anomalies contributing to their erectile dysfunction correlating with penile doppler ultrasound (PDUS) findings and clinical outcomes after surgical intervention.

Methods

Men (n = 26) with signs of early vascular shunting on PDUS underwent time-resolved, contrast-enhanced (0.1 mMol/kg gadobutrol at 1 ml/s followed by saline flush) 3-dimensional spoiled gradient echo T1-weighted MRA sequence performed over 3 min with 4.6 s frame rate after intracavernosal injection of an erectogenic agent. Additional T1- and T2-weighted sequences were performed for anatomic co-localization and tissue characterization. MRA images were evaluated for early filling of draining veins as well as arteriovenous malformations and fistulas and correlated with findings at surgery.

Results

29 MRA examinations on 26 patients (mean age 39 years) demonstrated abnormal early venous drainage (n = 22) as well as diminutive/delayed cavernosal enhancement (n = 3), incomplete tumescence (n = 2), and combined arterial inflow/venous outflow disease (n = 1). The MRA had a concordance of 85.2% at determining the presence, or lack thereof of a shunt/AVM when compared to PDUS.

Conclusions

Time-resolved MRA allows for both temporal and spatial resolution with visualization of both arterial and venous abnormalities which may be suggested with a screening PDUS examination. This technique allows us to provide detailed anatomic information prior to any surgical intervention.
Literature
1.
go back to reference McCabe MP, Sharlip ID, Atalla E, et al: Definitions of Sexual Dysfunctions in Women and Men: A Consensus Statement From the Fourth International Consultation on Sexual Medicine 2015. J. Sex. Med. 2016; 13: 135–43.CrossRefPubMed McCabe MP, Sharlip ID, Atalla E, et al: Definitions of Sexual Dysfunctions in Women and Men: A Consensus Statement From the Fourth International Consultation on Sexual Medicine 2015. J. Sex. Med. 2016; 13: 135–43.CrossRefPubMed
2.
go back to reference Prins J, Blanker MH, Bohnen AM, et al: Prevalence of erectile dysfunction: a systematic review of population-based studies. Int. J. Impot. Res. 2002; 14: 422–432.CrossRefPubMed Prins J, Blanker MH, Bohnen AM, et al: Prevalence of erectile dysfunction: a systematic review of population-based studies. Int. J. Impot. Res. 2002; 14: 422–432.CrossRefPubMed
3.
go back to reference Kubin M, Wagner G and Fugl-Meyer AR: Epidemiology of erectile dysfunction. Int. J. Impot. Res. 2003; 15: 63–71.CrossRefPubMed Kubin M, Wagner G and Fugl-Meyer AR: Epidemiology of erectile dysfunction. Int. J. Impot. Res. 2003; 15: 63–71.CrossRefPubMed
4.
go back to reference Vaucher L, Bolyakov A and Paduch DA: Evolving techniques to evaluate ejaculatory function. Curr. Opin. Urol. 2009; 19: 606–614.CrossRefPubMed Vaucher L, Bolyakov A and Paduch DA: Evolving techniques to evaluate ejaculatory function. Curr. Opin. Urol. 2009; 19: 606–614.CrossRefPubMed
5.
go back to reference Golijanin D, Singer E, Davis R, et al: Doppler evaluation of erectile dysfunction – Part 1. Int. J. Impot. Res. 2007; 19: 37–42.CrossRefPubMed Golijanin D, Singer E, Davis R, et al: Doppler evaluation of erectile dysfunction – Part 1. Int. J. Impot. Res. 2007; 19: 37–42.CrossRefPubMed
7.
go back to reference Rhoden EL, Telöken C, Sogari PR, et al: The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int. J. Impot. Res. 2002; 14: 245–250.CrossRefPubMed Rhoden EL, Telöken C, Sogari PR, et al: The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int. J. Impot. Res. 2002; 14: 245–250.CrossRefPubMed
8.
go back to reference Hosain GMM, Latini DM, Kauth M, et al: Sexual dysfunction among male veterans returning from Iraq and Afghanistan: prevalence and correlates. J. Sex. Med. 2013; 10: 516–523.CrossRefPubMed Hosain GMM, Latini DM, Kauth M, et al: Sexual dysfunction among male veterans returning from Iraq and Afghanistan: prevalence and correlates. J. Sex. Med. 2013; 10: 516–523.CrossRefPubMed
9.
go back to reference Laumann EO, West S, Glasser D, et al: Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: from the male attitudes regarding sexual health survey. J. Sex. Med. 2007; 4: 57–65.CrossRefPubMed Laumann EO, West S, Glasser D, et al: Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: from the male attitudes regarding sexual health survey. J. Sex. Med. 2007; 4: 57–65.CrossRefPubMed
10.
go back to reference Sand MS, Fisher W, Rosen R, et al: Erectile dysfunction and constructs of masculinity and quality of life in the multinational Men’s Attitudes to Life Events and Sexuality (MALES) study. J. Sex. Med. 2008; 5: 583–594.CrossRefPubMed Sand MS, Fisher W, Rosen R, et al: Erectile dysfunction and constructs of masculinity and quality of life in the multinational Men’s Attitudes to Life Events and Sexuality (MALES) study. J. Sex. Med. 2008; 5: 583–594.CrossRefPubMed
11.
go back to reference Nicolosi A, Glasser DB, Moreira ED, et al: Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study. Int. J. Impot. Res. 2003; 15: 253–257.CrossRefPubMed Nicolosi A, Glasser DB, Moreira ED, et al: Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study. Int. J. Impot. Res. 2003; 15: 253–257.CrossRefPubMed
12.
go back to reference Caskurlu T, Tasci AI, Resim S, et al: The etiology of erectile dysfunction and contributing factors in different age groups in Turkey. Int. J. Urol. Off. J. Jpn. Urol. Assoc. 2004; 11: 525–9. Caskurlu T, Tasci AI, Resim S, et al: The etiology of erectile dysfunction and contributing factors in different age groups in Turkey. Int. J. Urol. Off. J. Jpn. Urol. Assoc. 2004; 11: 525–9.
13.
go back to reference Ye T, Li J, Li L, et al: Computed tomography cavernosography combined with volume rendering to observe venous leakage in young patients with erectile dysfunction. Br. J. Radiol. 2018; 91: 20180118.CrossRefPubMedPubMedCentral Ye T, Li J, Li L, et al: Computed tomography cavernosography combined with volume rendering to observe venous leakage in young patients with erectile dysfunction. Br. J. Radiol. 2018; 91: 20180118.CrossRefPubMedPubMedCentral
14.
go back to reference Vargas HA, Donati OF, Wibmer A, et al: Association Between Penile Dynamic Contrast‐Enhanced MRI‐Derived Quantitative Parameters and Self‐Reported Sexual Function in Patients with Newly Diagnosed Prostate Cancer. J. Sex. Med. 2014; 11: 2581–2588.CrossRefPubMed Vargas HA, Donati OF, Wibmer A, et al: Association Between Penile Dynamic Contrast‐Enhanced MRI‐Derived Quantitative Parameters and Self‐Reported Sexual Function in Patients with Newly Diagnosed Prostate Cancer. J. Sex. Med. 2014; 11: 2581–2588.CrossRefPubMed
15.
go back to reference Glodny B, Petersen J, Bendix N, et al: Microcoil embolization of an arteriovenous fistula from the arteria bulbi penis to the corpus spongiosum penis in the treatment of erectile dysfunction: normal function regained immediately after intervention. Br. J. Radiol. 2007; 80: e265-267.CrossRefPubMed Glodny B, Petersen J, Bendix N, et al: Microcoil embolization of an arteriovenous fistula from the arteria bulbi penis to the corpus spongiosum penis in the treatment of erectile dysfunction: normal function regained immediately after intervention. Br. J. Radiol. 2007; 80: e265-267.CrossRefPubMed
16.
go back to reference Lurie AL, Bookstein JJ and Kessler WO: Posttraumatic impotence: angiographic evaluation. Radiology 1988; 166: 115–119.CrossRefPubMed Lurie AL, Bookstein JJ and Kessler WO: Posttraumatic impotence: angiographic evaluation. Radiology 1988; 166: 115–119.CrossRefPubMed
17.
go back to reference Papagiannopoulos D, Nehra A and Khare N: Evaluation of young men with organic erectile dysfunction. Asian J. Androl. 2015; 17: 11.CrossRefPubMed Papagiannopoulos D, Nehra A and Khare N: Evaluation of young men with organic erectile dysfunction. Asian J. Androl. 2015; 17: 11.CrossRefPubMed
18.
go back to reference Pretorius ES, Siegelman ES, Ramchandani P, et al: MR Imaging of the Penis. RadioGraphics 2001; 21: S283–S298. Pretorius ES, Siegelman ES, Ramchandani P, et al: MR Imaging of the Penis. RadioGraphics 2001; 21: S283–S298.
20.
go back to reference Parker RA, Menias CO, Quazi R, et al: MR Imaging of the Penis and Scrotum. RadioGraphics 2015; 35: 1033–1050.CrossRefPubMed Parker RA, Menias CO, Quazi R, et al: MR Imaging of the Penis and Scrotum. RadioGraphics 2015; 35: 1033–1050.CrossRefPubMed
21.
go back to reference Rosen RC, Catania J, Pollack L, et al: Male Sexual Health Questionnaire (MSHQ): Scale development and psychometric validation. Urology 2004; 64: 777–782.CrossRefPubMed Rosen RC, Catania J, Pollack L, et al: Male Sexual Health Questionnaire (MSHQ): Scale development and psychometric validation. Urology 2004; 64: 777–782.CrossRefPubMed
22.
go back to reference Henry BM, Pękala PA, Vikse J, et al: Variations in the Arterial Blood Supply to the Penis and the Accessory Pudendal Artery: A Meta-Analysis and Review of Implications in Radical Prostatectomy. J. Urol. 2017; 198: 345–353.CrossRefPubMed Henry BM, Pękala PA, Vikse J, et al: Variations in the Arterial Blood Supply to the Penis and the Accessory Pudendal Artery: A Meta-Analysis and Review of Implications in Radical Prostatectomy. J. Urol. 2017; 198: 345–353.CrossRefPubMed
23.
go back to reference Thai CT, Karam IM, Nguyen-Thi PL, et al: Pelvic magnetic resonance imaging angioanatomy of the arterial blood supply to the penis in suspected prostate cancer patients. Eur. J. Radiol. 2015; 84: 823–827.CrossRefPubMed Thai CT, Karam IM, Nguyen-Thi PL, et al: Pelvic magnetic resonance imaging angioanatomy of the arterial blood supply to the penis in suspected prostate cancer patients. Eur. J. Radiol. 2015; 84: 823–827.CrossRefPubMed
24.
go back to reference Erdoğru T, Kaplancan T, Aker O, et al: Cavernosal arterial anatomic variations and its effect on penile hemodynamic status. Eur. J. Ultrasound Off. J. Eur. Fed. Soc. Ultrasound Med. Biol. 2001; 14: 141–148. Erdoğru T, Kaplancan T, Aker O, et al: Cavernosal arterial anatomic variations and its effect on penile hemodynamic status. Eur. J. Ultrasound Off. J. Eur. Fed. Soc. Ultrasound Med. Biol. 2001; 14: 141–148.
25.
go back to reference Chiou RK, Alberts GL, Pomeroy BD, et al: Study of cavernosal arterial anatomy using color and power Doppler sonography: impact on hemodynamic parameter measurement. J. Urol. 1999; 162: 358–360.CrossRefPubMed Chiou RK, Alberts GL, Pomeroy BD, et al: Study of cavernosal arterial anatomy using color and power Doppler sonography: impact on hemodynamic parameter measurement. J. Urol. 1999; 162: 358–360.CrossRefPubMed
26.
go back to reference Sakamoto H, Nagata M, Saito K, et al: Anatomic variations of cavernous arteries and their effect on measurement of hemodynamic parameters: a power Doppler study. Urology 2004; 63: 539–544.CrossRefPubMed Sakamoto H, Nagata M, Saito K, et al: Anatomic variations of cavernous arteries and their effect on measurement of hemodynamic parameters: a power Doppler study. Urology 2004; 63: 539–544.CrossRefPubMed
27.
go back to reference Dean RC and Lue TF: Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Urol. Clin. North Am. 2005; 32: 379–v. Dean RC and Lue TF: Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction. Urol. Clin. North Am. 2005; 32: 379–v.
28.
go back to reference Hsu G-L, Hsieh C-H, Wen H-S, et al: Penile venous anatomy: application to surgery for erectile disturbance. Asian J. Androl. 2002; 4: 61–66.PubMed Hsu G-L, Hsieh C-H, Wen H-S, et al: Penile venous anatomy: application to surgery for erectile disturbance. Asian J. Androl. 2002; 4: 61–66.PubMed
29.
go back to reference Porst H, Burnett A, Brock G, et al: SOP conservative (medical and mechanical) treatment of erectile dysfunction. J. Sex. Med. 2013; 10: 130–171.CrossRefPubMed Porst H, Burnett A, Brock G, et al: SOP conservative (medical and mechanical) treatment of erectile dysfunction. J. Sex. Med. 2013; 10: 130–171.CrossRefPubMed
30.
go back to reference El-Sakka AI: What is the current role of intracavernosal injection in management of erectile dysfunction? Int. J. Impot. Res. 2016; 28: 88–95.CrossRefPubMed El-Sakka AI: What is the current role of intracavernosal injection in management of erectile dysfunction? Int. J. Impot. Res. 2016; 28: 88–95.CrossRefPubMed
31.
go back to reference Jung DC, Park SY and Lee JY: Penile Doppler ultrasonography revisited. Ultrasonography 2018; 37: 16–24.PubMed Jung DC, Park SY and Lee JY: Penile Doppler ultrasonography revisited. Ultrasonography 2018; 37: 16–24.PubMed
32.
go back to reference Najari BB, Introna L and Paduch DA: Improvements in Patient-reported Sexual Function After Microsurgical Varicocelectomy. Urology 2017; 110: 104–109.CrossRefPubMed Najari BB, Introna L and Paduch DA: Improvements in Patient-reported Sexual Function After Microsurgical Varicocelectomy. Urology 2017; 110: 104–109.CrossRefPubMed
33.
34.
go back to reference Donatucci CF and Lue TF: Erectile dysfunction in men under 40: etiology and treatment choice. Int. J. Impot. Res. 1993; 5: 97–103.PubMed Donatucci CF and Lue TF: Erectile dysfunction in men under 40: etiology and treatment choice. Int. J. Impot. Res. 1993; 5: 97–103.PubMed
35.
go back to reference Tiguert R, Harb JF, Hurley PM, et al: Management of shotgun injuries to the pelvis and lower genitourinary system. Urology 2000; 55: 193–197.CrossRefPubMed Tiguert R, Harb JF, Hurley PM, et al: Management of shotgun injuries to the pelvis and lower genitourinary system. Urology 2000; 55: 193–197.CrossRefPubMed
37.
go back to reference Szafran AA, Redett R and Burnett AL: Penile transplantation: the US experience and institutional program set-up. Transl. Androl. Urol. 2018; 7: 639–645.CrossRefPubMedPubMedCentral Szafran AA, Redett R and Burnett AL: Penile transplantation: the US experience and institutional program set-up. Transl. Androl. Urol. 2018; 7: 639–645.CrossRefPubMedPubMedCentral
Metadata
Title
Utility of dynamic MRA in the evaluation of male erectile dysfunction
Authors
Alexandra Roudenko
Rand N. Wilcox Vanden Berg
Christopher Song
Martin R. Prince
Darius A. Paduch
Daniel Margolis
Publication date
01-07-2020
Publisher
Springer US
Published in
Abdominal Radiology / Issue 7/2020
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-019-02339-y

Other articles of this Issue 7/2020

Abdominal Radiology 7/2020 Go to the issue

Special Section: Male Pelvis

Imaging of scrotal masses

Special Section: Distinguished Papers from JSAR

Mass-forming hepatic cryptococcosis: a mimicker of metastatic tumors

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.