Published in:
01-03-2010 | Original Paper
Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report
Authors:
Rui Niimi, Akihiko Matsumine, Katsuyuki Kusuzaki, Ken Shintani, Tomoki Nakamura, Hideki Kotera, Tetsuya Murata, Atsumasa Uchida
Published in:
Medical Oncology
|
Issue 1/2010
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Abstract
A rare case of post-radiation epithelioid hemangioendothelioma arising in a congenital hemangioma of the lower leg 18 years after radiotherapy is reported. At 7 years of age, the patient underwent partial resection of a subcutaneous congenital hemangioma with intramuscular extension of the left lower leg, and at 10 years of age, the patient was given radiotherapy with a total dose of 30 Gy for recurrence. At 28 years of age, the patient noticed a large tumor mass with intractable pain at the antero-lateral aspect of the proximal lower leg, and she presented to our hospital. Since microscopic examination of a biopsy specimen showed epithelioid hemangioendothelioma, disarticulation at the knee joint was performed. Although malignant change in a benign vascular tumor is extremely rare, irradiation can induce malignant transformation of a hemangioma.