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Medical Oncology
Published in: Medical Oncology 4/2011

01-12-2011 | Original Paper

Epigenetic regulation of retinoic acid receptor β2 gene in the initiation of breast cancer

Authors: Jingyan Sun, Xu Xu, Juntian Liu, Hong Liu, Li Fu, Lin Gu

Published in: Medical Oncology | Issue 4/2011

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Abstract

In order to investigate the methylation status of the retinoic acid receptor beta 2 gene (RAR-β2) in breast carcinoma in relation to gene expression and clinicopathological parameters of patients with breast cancer, expression of RAR-β2 gene and methylation status were analyzed in invasive carcinoma, atypical ductal hyperplasia, fibroadenoma specimens, and normal tissues. Our findings showed that RAR-β2 expression was lower in the breast cancer compared to normal tissue and fibroadenoma. The methylation rate of RAR-β2 in breast cancer and precancerous lesions of breast cancer were higher than that of normal tissues. Hypermethylation may be an initial step in breast carcinogenesis.
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Metadata
Title
Epigenetic regulation of retinoic acid receptor β2 gene in the initiation of breast cancer
Authors
Jingyan Sun
Xu Xu
Juntian Liu
Hong Liu
Li Fu
Lin Gu
Publication date
01-12-2011
Publisher
Springer US
Published in
Medical Oncology / Issue 4/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9685-y

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