Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2009

Open Access 01-12-2009 | Review

Epigenetic regulation in mammalian preimplantation embryo development

Authors: Lingjun Shi, Ji Wu

Published in: Reproductive Biology and Endocrinology | Issue 1/2009

Login to get access

Abstract

Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin is modified and core histone elements undergo significant changes. Each preimplantation embryo stage has its own characteristic epigenetic profile, consistent with the acquisition of the capacity to support development. Moreover, histone modifications such as methylation and acetylation as well as other epigenetic events can act as regulatory switches of gene transcription. Because the epigenetic profile is largely related to differentiation, epigenetic dysfunction can give rise to developmental abnormalities. Thus, epigenetic profiling of the embryo is of pivotal importance clinically. Given the importance of these aspects, this review will mainly focus on the epigenetic profile during preimplantation embryo development, as well as interactions between epigenetic and genetic regulation in these early developmental stages.
Appendix
Available only for authorised users
Literature
1.
Epstein CJ, Smith SA: Electrophoretic analysis of proteins synthesized by preimplantation mouse embryos. Dev Biol. 1974, 40 (2): 233-244.PubMedCrossRef
2.
Weng DE, Morgan RA, Gearhart JD: Estimates of mRNA abundance in the mouse blastocyst based on cDNA library analysis. Mol Reprod Dev. 1989, 1 (4): 233-241.PubMedCrossRef
3.
Ma J, Svoboda P, Schultz RM, Stein P: Regulation of Zygotic Gene Activation in the Preimplantation Mouse Embryo: Global Activation and Repression of Gene Expression. Biol Reprod. 2001, 64 (6): 1713-1721.PubMedCrossRef
4.
Zeng F, Schultz RM: Gene expression in mouse oocytes and preimplantation embryos: use of suppression subtractive hybridization to identify oocyte- and embryo-specific genes. Biol Reprod. 2003, 68 (1): 31-39.PubMedCrossRef
5.
Misirlioglu M, Page GP, Sagirkaya H, Kaya A, Parrish JJ, First NL, Memili E: Dynamics of global transcriptome in bovine matured oocytes and preimplantation embryos. Proc Natl Acad Sci USA. 2006, 103 (50): 18905-18910.PubMedCentralPubMedCrossRef
6.
Li SS, Liu YH, Tseng CN, Singh S: Analysis of gene expression in single human oocytes and preimplantation embryos. Biochem Biophys Res Commun. 2006, 340 (1): 48-53.PubMedCrossRef
7.
Hamatani T, Ko M, Yamada M, Kuji N, Mizusawa Y, Shoji M, Hada T, Asada H, Maruyama T, Yoshimura Y: Global gene expression profiling of preimplantation embryos. Hum Cell. 2006, 19 (3): 98-117.PubMedCrossRef
8.
Hamatani T, Carter MG, Sharov AA, Ko MS: Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell. 2004, 6 (1): 117-131.PubMedCrossRef
9.
Goldberg AD, Allis CD, Bernstein E: Epigenetics: a landscape takes shape. Cell. 2007, 128 (4): 635-638.PubMedCrossRef
10.
Monk M, Boubelik M, Lehnert S: Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development. 1987, 99 (3): 371-382.PubMed
11.
Monk M, Adams RL, Rinaldi A: Decrease in DNA methylase activity during preimplantation development in the mouse. Development. 1991, 112 (1): 189-192.PubMed
12.
Santos F, Peters AH, Otte AP, Reik W, Dean W: Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Dev Biol. 2005, 280 (1): 225-236.PubMedCrossRef
13.
Yeo S, Lee KK, Han YM, Kang YK: Methylation changes of lysine 9 of histone H3 during preimplantation mouse development. Mol Cells. 2005, 20 (3): 423-428.PubMed
14.
Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T, Zernicka-Goetz M: Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. Int J Dev Biol. 2006, 50 (5): 455-461.PubMed
15.
Kimmins S, Sassone-Corsi P: Chromatin remodelling and epigenetic features of germ cells. Nature. 2005, 434 (7033): 583-589.PubMedCrossRef
16.
Hayashi K, Yoshida K, Matsui Y: A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature. 2005, 438 (7066): 374-378.PubMedCrossRef
17.
Holliday R, Pugh JE: DNA modification mechanisms and gene activity during development. Science. 1975, 187 (4173): 226-232.PubMedCrossRef
18.
Sulewska A, Niklinska W, Kozlowski M, Minarowski L, Naumnik W, Niklinski J, Dabrowska K, Chyczewski L: Detection of DNA methylation in eucaryotic cells. Folia Histochem Cytobiol. 2007, 45 (4): 315-324.PubMed
19.
Lister R, O'Malley RC, Tonti-Filippini J, Gregory BD, Berry CC, Millar AH, Ecker JR: Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis. 2008, 133 (3): 523-536.
20.
Li E: Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002, 3 (9): 662-673.PubMedCrossRef
21.
Vassena R, Schramm RD, E Latham K: Species-dependent expression patterns of DNA methyltransferase genes in mammalian oocytes and preimplantation embryos. Mol Reprod Dev. 2005, 72 (4): 430-436.PubMedCrossRef
22.
Hata K, Okano M, Lei H, Li E: Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002, 129 (8): 1983-1993.PubMed
23.
Krakauer DC, Mira A: Mitochondria and the death of oocytes. Nature. 2000, 403 (6769): 501-501.CrossRef
24.
Rougier N, Bourc'his D, Gomes DM, Niveleau A, Plachot M, Pàldi A, Viegas-Péquignot E: Chromosome methylation patterns during mammalian preimplantation development. Genes & Development. 1998, 12 (14): 2108-2113.CrossRef
25.
Santos F, Hendrich B, Reik W, Dean W: Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo. Developmental Biology. 2002, 241 (1): 172-182.PubMedCrossRef
26.
Morgan HD, Santos F, Green K, Dean W, Reik W: Epigenetic reprogramming in mammals. Hum Mol Genet. 2005, 14 (Spec No 1): R47-58.PubMedCrossRef
27.
Reik W: Stability and flexibility of epigenetic gene regulation in mammalian development. Nature. 2007, 447 (7143): 425-432.PubMedCrossRef
28.
Arányi T, Páldi A: The constant variation: DNA methylation changes during preimplantation development. FEBS Letters. 2006, 580 (28–29): 6521-6526.PubMedCrossRef
29.
Young LE, Beaujean N: DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep. Animal Reproduction Science. 2004, 82–83: 61-78.PubMedCrossRef
30.
Shi W, Dirim F, Wolf E, Zakhartchenko V, Haaf T: Methylation Reprogramming and Chromosomal Aneuploidy in In Vivo Fertilized and Cloned Rabbit Preimplantation Embryos. Biol Reprod. 2004, 71 (1): 340-347.PubMedCrossRef
31.
Fulka H, Mrazek M, Tepla O, Fulka JJ: DNA methylation pattern in human zygotes and developing embryos. Reproduction. 2004, 128 (6): 703-708.PubMedCrossRef
32.
Hirasawa R, Chiba H, Kaneda M, Tajima S, Li E, Jaenisch R, Sasaki H: Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 2008, 22 (12): 1607-1616.PubMedCentralPubMedCrossRef
33.
Kurihara Y, Kawamura Y, Uchijima Y, Amamo T, Kobayashi H, Asano T, Kurihara H: Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1. Developmental Biology. 2008, 313 (1): 335-346.PubMedCrossRef
34.
Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC: A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints. 2008, 15 (4): 547-557.
35.
Ko YG, Nishino K, Hattori N, Arai Y, Tanaka S, Shiota K: Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development. J Biol Chem. 2005, 280 (10): 9627-9634.PubMedCrossRef
36.
May A, Kirchner R, Muller H, Hartmann P, El Hajj N, Tresch A, Zechner U, Mann W, Haaf T: Multiplex RT-PCR Expression Analysis of Developmentally Important Genes in Individual Mouse Preimplantation Embryos and Blastomeres. Biol Reprod. 2008
37.
38.
Villar-Garea A, Imhof A: The analysis of histone modifications. Biochimica et Biophysica Acta (BBA) – Proteins & Proteomics. 2006, 1764 (12): 1932-1939.CrossRef
39.
Huang JC, Lei ZL, Shi LH, Miao YL, Yang JW, Ouyang YC, Sun QY, Chen DY: Comparison of histone modifications in in vivo and in vitro fertilization mouse embryos. Biochem Biophys Res Commun. 2007, 354 (1): 77-83.PubMedCrossRef
40.
Prigent C, Dimitrov S: Phosphorylation of serine 10 in histone H3, what for?. J Cell Sci. 2003, 116 (18): 3677-3685.PubMedCrossRef
41.
Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH: Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol. 2003, 13 (14): 1192-1200.PubMedCrossRef
42.
Kantor B, Makedonski K, Shemer R, Razin A: Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. Gene Expression Patterns. 2003, 3 (6): 697-702.PubMedCrossRef
43.
Adenot P, Mercier Y, Renard J, Thompson E: Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos. Development. 1997, 124 (22): 4615-4625.PubMed
44.
Santos F, Peters AH, Otte AP, Reik W, Dean W: Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Developmental Biology. 2005, 280 (1): 225-236.PubMedCrossRef
45.
Kourmouli N, Jeppesen P, Mahadevhaiah S, Burgoyne P, Wu R, Gilbert DM, Bongiorni S, Prantera G, Fanti L, Pimpinelli S, et al: Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J Cell Sci. 2004, 117 (12): 2491-2501.PubMedCrossRef
46.
47.
Sarmento OF, Digilio LC, Wang Y, Perlin J, Herr JC, Allis CD, Coonrod SA: Dynamic alterations of specific histone modifications during early murine development. J Cell Sci. 2004, 117 (19): 4449-4459.PubMedCrossRef
48.
Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y: G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol. 2006, 8 (2): 188-194.PubMedCrossRef
49.
Erhardt S, Su I-h, Schneider R, Barton S, Bannister AJ, Perez-Burgos L, Jenuwein T, Kouzarides T, Tarakhovsky A, Surani MA: Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development. 2003, 130 (18): 4235-4248.PubMedCrossRef
50.
Witt O, Deubzer HE, Milde T, Oehme I: HDAC family: What are the cancer relevant targets?. Cancer Letters. 2009, 277 (1): 8-21.PubMedCrossRef
51.
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K-i, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, et al: PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet. 2008, 40 (4): 411-420.PubMedCrossRef
52.
Dodge JE, Kang Y-K, Beppu H, Lei H, Li E: Histone H3-K9 Methyltransferase ESET Is Essential for Early Development. Mol Cell Biol. 2004, 24 (6): 2478-2486.PubMedCentralPubMedCrossRef
53.
Ma P, Schultz RM: Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev Biol. 2008, 319 (1): 110-120.PubMedCentralPubMedCrossRef
54.
55.
Bultman SJ, Gebuhr TC, Pan H, Svoboda P, Schultz RM, Magnuson T: Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev. 2006, 20 (13): 1744-1754.PubMedCentralPubMedCrossRef
56.
Sun F, Tang F, Yan AY, Fang HY, Sheng HZ: Expression of SRG3, a chromatin-remodelling factor, in the mouse oocyte and early preimplantation embryos. Zygote. 2007, 15 (2): 129-138.PubMedCrossRef
57.
Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ: Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature. 1997, 389 (6648): 251-260.PubMedCrossRef
58.
Palmer DK, O'Day K, Trong HL, Charbonneau H, Margolis RL: Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. Proc Natl Acad Sci USA. 1991, 88 (9): 3734-3738.PubMedCentralPubMedCrossRef
59.
Ahmad K, Henikoff S: The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly. Molecular Cell. 2002, 9 (6): 1191-1200.PubMedCrossRef
60.
61.
Fu G, Ghadam P, Sirotkin A, Khochbin S, Skoultchi AI, Clarke HJ: Mouse oocytes and early embryos express multiple histone H1 subtypes. Biol Reprod. 2003, 68 (5): 1569-1576.PubMedCrossRef
62.
Chang C-C, Ma Y, Jacobs S, Tian XC, Yang X, Rasmussen TP: A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos. Developmental Biology. 2005, 278 (2): 367-380.PubMedCrossRef
63.
Sarma K, Reinberg D: Histone variants meet their match. Nat Rev Mol Cell Biol. 2005, 6 (2): 139-149.PubMedCrossRef
64.
Chadwick BP, Willard HF: A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome. J Cell Biol. 2001, 152 (2): 375-384.PubMedCentralPubMedCrossRef
65.
Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993, 75 (5): 843-854.PubMedCrossRef
66.
Wightman B, Ha I, Ruvkun G: Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993, 75 (5): 855-862.PubMedCrossRef
67.
68.
69.
Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ: Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci USA. 2005, 102 (34): 12135-12140.PubMedCentralPubMedCrossRef
70.
Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E, Zernicka-Goetz M: Maternal Argonaute 2 Is Essential for Early Mouse Development at the Maternal-Zygotic Transition. Mol Biol Cell. 2008, 19 (10): 4383-4392.PubMedCentralPubMedCrossRef
71.
Yang Y, Bai W, Zhang L, Yin G, Wang X, Wang J, Zhao H, Han Y, Yao YQ: Determination of microRNAs in mouse preimplantation embryos by microarray. Dev Dyn. 2008, 237 (9): 2315-2327.PubMedCrossRef
72.
Whitehead J, Pandey GK, Kanduri C: Regulation of the mammalian epigenome by long noncoding RNAs. Biochimica et Biophysica Acta (BBA) – General Subjects. 2008, Corrected Proof
73.
74.
Houseley J, Rubbi L, Grunstein M, Tollervey D, Vogelauer M: A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster. Mol Cell. 2008, 32 (5): 685-695.PubMedCrossRef
75.
Seim I, Carter S, Herington A, Chopin L: Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene. BMC Molecular Biology. 2008, 9 (1): 95-PubMedCentralPubMedCrossRef
76.
Nagano T, Mitchell JA, Sanz LA, Pauler FM, Ferguson-Smith AC, Feil R, Fraser P: The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin. Science. 2008, 322 (5908): 1717-1720.PubMedCrossRef
77.
Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W: Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006, 133 (21): 4203-4210.PubMedCrossRef
78.
Verhaagh S, Schweifer N, Barlow DP, Zwart R: Cloning of the Mouse and Human Solute Carrier 22a3 (Slc22a3/SLC22A3) Identifies a Conserved Cluster of Three Organic Cation Transporters on Mouse Chromosome 17 and Human 6q26-q27. Genomics. 1999, 55 (2): 209-218.PubMedCrossRef
79.
Hartman MA, Kreiling JL, Byrd JC, MacDonald RG: High-affinity ligand binding by wild-type/mutant heteromeric complexes of the mannose 6-phosphate/insulin-like growth factor II receptor. FEBS Journal. 2009, 276 (7): 1915-1929.PubMedCentralPubMedCrossRef
80.
Sheardown SA, Duthie SM, Johnston CM, Newall AE, Formstone EJ, Arkell RM, Nesterova TB, Alghisi GC, Rastan S, Brockdorff N: Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Cell. 1997, 91 (1): 99-107.PubMedCrossRef
81.
Huynh KD, Lee JT: Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature. 2003, 426 (6968): 857-862.PubMedCrossRef
82.
Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N: Reactivation of the paternal X chromosome in early mouse embryos. Science. 2004, 303 (5658): 666-669.PubMedCrossRef
83.
Avner P, Heard E: X-chromosome inactivation: counting, choice and initiation. Nat Rev Genet. 2001, 2 (1): 59-67.PubMedCrossRef
84.
Lee JT: Functional intergenic transcription: a case study of the X inactivation centre. Philos Trans R Soc Lond B Biol Sci. 2003, 358 (1436): 1417-1423.PubMedCentralPubMedCrossRef
85.
Navarro P, Pichard S, Ciaudo C, Avner P, Rougeulle C: Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation. Genes Dev. 2005, 19 (12): 1474-1484.PubMedCentralPubMedCrossRef
86.
Sado T, Hoki Y, Sasaki H: Tsix silences Xist through modification of chromatin structure. Dev Cell. 2005, 9 (1): 159-165.PubMedCrossRef
87.
Sun BK, Deaton AM, Lee JT: A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell. 2006, 21 (5): 617-628.PubMedCrossRef
88.
Lee JT: Regulation of X-chromosome counting by Tsix and Xite sequences. Science. 2005, 309 (5735): 768-771.PubMedCrossRef
89.
Xu N, Tsai CL, Lee JT: Transient homologous chromosome pairing marks the onset of X inactivation. Science. 2006, 311 (5764): 1149-1152.PubMedCrossRef
90.
Zhao J, Sun BK, Erwin JA, Song J-J, Lee JT: Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome. Science. 2008, 322 (5902): 750-756.PubMedCentralPubMedCrossRef
91.
Heard E: Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome. Current Opinion in Genetics & Development. 2005, 15 (5): 482-489.CrossRef
92.
Mlynarczyk-Evans S, Royce-Tolland M, Alexander MK, Andersen AA, Kalantry S, Gribnau J, Panning B: X Chromosomes Alternate between Two States prior to Random X-Inactivation. PLoS Biol. 2006, 4 (6): e159-PubMedCentralPubMedCrossRef
93.
Augui S, Filion GJ, Huart S, Nora E, Guggiari M, Maresca M, Stewart AF, Heard E: Sensing X Chromosome Pairs Before X Inactivation via a Novel X-Pairing Region of the Xic. Science. 2007, 318 (5856): 1632-1636.PubMedCrossRef
94.
Nguyen DK, Disteche CM: Dosage compensation of the active X chromosome in mammals. Nat Genet. 2006, 38 (1): 47-53.PubMedCrossRef
95.
Lin H, Gupta V, VerMilyea MD, Falciani F, Lee JT, O'Neill LP, Turner BM: Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes. PLoS Biol. 2007, 5 (12): e326-PubMedCentralPubMedCrossRef
96.
Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, Lou Y, Yang J, Ma Y, Chai L, et al: Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol. 2006, 8 (10): 1114-1123.PubMedCrossRef
97.
Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H: Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mechanisms of Development. 2008, 125 (3–4): 270-283.PubMedCrossRef
98.
Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, Shiota K: Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells. J Biol Chem. 2004, 279 (17): 17063-17069.PubMedCrossRef
99.
Kuroda T, Tada M, Kubota H, Kimura H, Hatano SY, Suemori H, Nakatsuji N, Tada T: Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol. 2005, 25 (6): 2475-2485.PubMedCentralPubMedCrossRef
100.
Naoko H, Yuko I, Koichiro N, Naka H, Jun O, Shintaro Y, Satoshi T, Kunio S: Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes to Cells. 2007, 12 (3): 387-396.CrossRef
101.
Byrne MJ, Warner CM: MicroRNA expression in preimplantation mouse embryos from Ped gene positive compared to Ped gene negative mice. J Assist Reprod Genet. 2008, 25 (5): 205-214.PubMedCentralPubMedCrossRef
102.
Whitelaw E, Martin DIK: Retrotransposons as epigenetic mediators of phenotypic variation in mammals. Nat Genet. 2001, 27 (4): 361-365.PubMedCrossRef
103.
Han JS, Szak ST, Boeke JD: Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature. 2004, 429 (6989): 268-274.PubMedCrossRef
104.
Beraldi R, Pittoggi C, Sciamanna I, Mattei E, Spadafora C: Expression of LINE-1 retroposons is essential for murine preimplantation development. Mol Reprod Dev. 2006, 73 (3): 279-287.PubMedCrossRef
105.
Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu L-F, Songyang Z, Thomson JA, Zwaka TP: Ronin Is Essential for Embryogenesis and the Pluripotency of Mouse Embryonic Stem Cells. Cell. 2008, 133 (7): 1162-1174.PubMedCentralPubMedCrossRef
106.
Weksberg R, Shuman C, Caluseriu O, Smith AC, Fei Y-L, Nishikawa J, Stockley TL, Best L, Chitayat D, Olney A, et al: Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome. Hum Mol Genet. 2002, 11 (11): 1317-1325.PubMedCrossRef
107.
Yamazawa K, Kagami M, Fukami M, Matsubara K, Ogata T: Monozygotic female twins discordant for Silver-Russell syndrome and hypomethylation of the H19-DMR. Journal of Human Genetics. 2008, 53 (10): 950-955.PubMedCrossRef
108.
Maarel van der SM: Epigenetic mechanisms in health and disease. Ann Rheum Dis. 2008, 67 (Suppl 3): iii97-100.PubMed
109.
Tost J: DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker. Methods Mol Biol. 2009, 507: 3-20.PubMedCrossRef
110.
Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, et al: H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias. 2008, 14 (5): 355-368.
Metadata
Title
Epigenetic regulation in mammalian preimplantation embryo development
Authors
Lingjun Shi
Ji Wu
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2009
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-7-59

Other articles of this Issue 1/2009

Reproductive Biology and Endocrinology 1/2009 Go to the issue

Research

Uterine and placental expression of TRPV6 gene is regulated via progesterone receptor- or estrogen receptor-mediated pathways during pregnancy in rodents

Research

Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats

Review

Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system

Research

Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervix

Research

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues

Research

Plexin-B1, glycodelin and MMP7 expression in the human fallopian tube and in the endometrium