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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 5/2024

Open Access 01-06-2024 | Epidermodysplasia Verruciformis | Obituary

Gérard Orth: From Viral to Human Genes Underlying Warts

Authors: Jean-Laurent Casanova, Emmanuelle Jouanguy

Published in: Journal of Clinical Immunology | Issue 5/2024

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Excerpt

Gérard Orth was born in 1936 and died in 2023. He was picky and prickly. He was sharp and scholarly. He was stern and serious. We loved him, even when he scolded us for forgetting a footnote to an abstract for a communication at a small workshop in a tiny town in the middle of nowhere in the 1960s. Detail was everything to him, but he was also unique in his global vision, which enabled him to make biological and medical breakthroughs in rabbits and humans, but also to discover both viral and host determinants of health and disease. …
Literature
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Lepine P. Present status of vaccination against poliomyelitis. Rev Pathol Gen Physiol Clin. 1957;57(692):1529–40.PubMed
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Lepine P. Determination of production of in vitro cultures of poliomyelitis virus by evaluating the numerical relationship between cellule-host and free virus. C R Hebd Seances Acad Sci. 1954;239(22):1555–6.PubMed
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Orth G, Atanasiu P, Boiron M, Rebiere JP, Paoletti C. Infectious and oncogenic effect of DNA extracted from cells infected with polyoma virus. Proc Soc Exp Biol Med. 1964;115:1090–5.CrossRefPubMed
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Rogers S, Moore M. Studies of the mechanism of action of the Shope rabbit papilloma virus. I. Concerning the nature of the induction of arginase in the infected cells. J Exp Med. 1963;117(3):521–42.CrossRefPubMedPubMedCentral
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Vielle-Breitburd F, Orth G. Rabbit liver L-arginase. Purification, properties, and subunit structure. J Biol Chem. 1972;247(4):1227–35.CrossRefPubMed
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Vielle-Breitburd F, Orth G. Structure of rabbit hepatic L-arginase. C R Hebd Seances Acad Sci D. 1971;272(18):2389–92.
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Jablonska S, Dabrowski J, Jakubowicz K. Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis. Cancer Res. 1972;32(3):583–9.PubMed
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Pass F, Reissig M, Shah KV, Eisinger M, Orth G. Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis. J Natl Cancer Inst. 1977;59(4):1107–12.CrossRefPubMed
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25.
Deau MC, Favre M, Orth G. Genetic heterogeneity among human papillomaviruses (HPV) associated with epidermodysplasia verruciformis: evidence for multiple allelic forms of HPV5 and HPV8 E6 genes. Virology. 1991;184(2):492–503.CrossRefPubMed
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de Jong SJ, Crequer A, Matos I, Hum D, Gunasekharan V, Lorenzo L, et al. The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to beta-papillomaviruses. J Exp Med. 2018;215(9):2289–310.CrossRefPubMedPubMedCentral
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Metadata
Title
Gérard Orth: From Viral to Human Genes Underlying Warts
Authors
Jean-Laurent Casanova
Emmanuelle Jouanguy
Publication date
01-06-2024
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 5/2024
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-024-01704-x

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