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Published in: Digestive Diseases and Sciences 9/2009

01-09-2009 | Review

Eosinophilic Esophagitis

Authors: Fouad J. Moawad, Ganesh R. Veerappan, Roy K. Wong

Published in: Digestive Diseases and Sciences | Issue 9/2009

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Abstract

Eosinophilic esophagitis is a chronic inflammatory disorder characterized by dense eosinophilic infiltration of the esophageal mucosa. The pathogenesis is incompletely understood and food allergies and aeroallergens have been implicated. The most common clinical presentation in adults is dysphagia to solids. Its associated endoscopic findings are distinct and include concentric rings and longitudinal furrows, although endoscopy may be unremarkable in a minority of patients. A number of management strategies exist; however, data are limited in adults, and only a few are based on randomized controlled trials. Management options include dietary modifications, pharmacological therapy, and endoscopic dilation.
Literature
16.
go back to reference Francalanci P, De Angelis P, Minnei F, et al. Eosinophilic esophagitis and Barrett’s esophagus: an occasional association or an overlap disease? Esophageal ‘double trouble’ in two children. Digestion. 2008;77:16–19. doi:10.1159/000114828.PubMedCrossRef Francalanci P, De Angelis P, Minnei F, et al. Eosinophilic esophagitis and Barrett’s esophagus: an occasional association or an overlap disease? Esophageal ‘double trouble’ in two children. Digestion. 2008;77:16–19. doi:10.​1159/​000114828.PubMedCrossRef
22.
26.
30.
go back to reference Mishra A, Hogan SP, Brandt EB, Rothenberg ME. Il-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002;168:2464–2469.PubMed Mishra A, Hogan SP, Brandt EB, Rothenberg ME. Il-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002;168:2464–2469.PubMed
33.
47.
49.
51.
go back to reference Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–343.PubMedCrossRef Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–343.PubMedCrossRef
62.
68.
go back to reference Straumann A, Bussmann C, Conus S. Infliximab, a monoclonal antibody to TNF-a, for severe eosinophilic esophagitis in adults: a prospective, translational pilot-study. Gastroenterology. 2008;134(Supp1):A-105.CrossRef Straumann A, Bussmann C, Conus S. Infliximab, a monoclonal antibody to TNF-a, for severe eosinophilic esophagitis in adults: a prospective, translational pilot-study. Gastroenterology. 2008;134(Supp1):A-105.CrossRef
71.
go back to reference Pasha SF, Sharma VK, Crowell MD. Current concepts and treatment options in eosinophilic esophagitis. Curr Opin Investig Drugs. 2006;7:992–996.PubMed Pasha SF, Sharma VK, Crowell MD. Current concepts and treatment options in eosinophilic esophagitis. Curr Opin Investig Drugs. 2006;7:992–996.PubMed
74.
75.
go back to reference Schoepfer AM, Gschossmann J, Scheurer U, Seibold F, Straumann A. Esophageal strictures in adult eosinophilic esophagitis: dilation is an effective and safe alternative after failure of topical corticosteroids. Endoscopy. 2008;40:161–164. doi:10.1055/s-2007-995345.PubMedCrossRef Schoepfer AM, Gschossmann J, Scheurer U, Seibold F, Straumann A. Esophageal strictures in adult eosinophilic esophagitis: dilation is an effective and safe alternative after failure of topical corticosteroids. Endoscopy. 2008;40:161–164. doi:10.​1055/​s-2007-995345.PubMedCrossRef
Metadata
Title
Eosinophilic Esophagitis
Authors
Fouad J. Moawad
Ganesh R. Veerappan
Roy K. Wong
Publication date
01-09-2009
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 9/2009
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-009-0873-6

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