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01-09-2019 | Short Communication

Ensemble encoding of action speed by striatal fast-spiking interneurons

Authors: Bradley M. Roberts, Michael G. White, Mary H. Patton, Rong Chen, Brian N. Mathur

Published in: Brain Structure and Function | Issue 7/2019

Abstract

Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhibition on downstream striatal projection neurons. While some in vivo single-unit electrophysiological recordings of putative FSIs support coordinated firing, others do not. Moreover, it is unclear as to what aspect of action FSIs encode. To address this, we used in vivo calcium imaging of genetically identified FSIs in freely moving mice and applied machine learning analyses to decipher the relationship between FSI activity and movement. We report that FSIs exhibit ensemble activity that encodes the speed of action sub-components, including ambulation and head movements. These results suggest FSI population dynamics fit within a Hebbian model for ensemble inhibition of striatal output guiding action.

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Title: Ensemble encoding of action speed by striatal fast-spiking interneurons
Authors: Bradley M. Roberts
Michael G. White
Mary H. Patton
Rong Chen
Brian N. Mathur
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 7/2019
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01908-7

At a glance: The STEP trials

Springer Medicine

Ensemble encoding of action speed by striatal fast-spiking interneurons

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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