Skip to main content
Top
Published in: International Journal of Colorectal Disease 1/2011

Open Access 01-01-2011 | Original Article

Enhanced recovery program in laparoscopic colectomy for cancer

Authors: Jensen T. C. Poon, Joe K. M. Fan, Oswens S. H. Lo, Wai Lun Law

Published in: International Journal of Colorectal Disease | Issue 1/2011

Login to get access

Abstract

Introduction

Both laparoscopic colectomy and application of enhanced recovery program (ERP) in open colectomy have been demonstrated to enable early recovery and to shorten hospital stay. This study evaluated the impact of ERP on results of laparoscopic colectomy and comparison was made with the outcomes of patients prior to the application of ERP.

Methods

An ERP was implemented in the authors’ center in December 2006. Short-term outcomes of consecutive 84 patients who underwent laparoscopic colonic cancer resection 23 months before (control group) and 96 patients who were operated within 13 months; after application of ERP (ERP group) were compared.

Results

Between the ERP and control groups, there was no statistical difference in patient characteristics, pathology, operating time, blood loss, conversion rate or complications. Compared to the control group, patients in the ERP group had earlier passage of flatus [2 (range: 1–5) versus 2 (range: 1–4) days after operation respectively; p = 0.03)] and a lower incidence of prolonged post-operative ileus (6% versus 0 respectively; p = 0.02). There was no difference in the hospital stay between the two groups [4 (range: 2–34) days in control group and 4 (range: 2–23) days in ERP group; p = 0.4)]. The re-admission rate was also similar (7% in control group and 5% in ERP group; p = 0.59).

Conclusions

In laparoscopic colectomy for cancer, application of ERP was associated with no increase in complication rate but significant improvement of gastrointestinal function. ERP further hastened patient recovery but resulted in no difference in hospital stay.
Literature
1.
go back to reference Clinical Outcomes of Surgical Therapy (COST) Study Group (2004) A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350(20):2050–2059CrossRef Clinical Outcomes of Surgical Therapy (COST) Study Group (2004) A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350(20):2050–2059CrossRef
2.
go back to reference Guillou PJ, Quirke P, Thorpe H et al (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365(9472):1718–1726CrossRefPubMed Guillou PJ, Quirke P, Thorpe H et al (2005) Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 365(9472):1718–1726CrossRefPubMed
3.
go back to reference Hewett PJ, Allardyce RA, Bagshaw PF et al (2008) Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: the ALCCaS trial. Ann Surg 248(5):728–738CrossRefPubMed Hewett PJ, Allardyce RA, Bagshaw PF et al (2008) Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: the ALCCaS trial. Ann Surg 248(5):728–738CrossRefPubMed
4.
go back to reference Jayne DG, Guillou PJ, Thorpe H et al (2007) Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol 25(21):3061–3068CrossRefPubMed Jayne DG, Guillou PJ, Thorpe H et al (2007) Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol 25(21):3061–3068CrossRefPubMed
5.
go back to reference Law WL, Lee YM, Choi HK, Seto CL, Ho JW (2007) Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival. Ann Surg 245(1):1–7CrossRefPubMed Law WL, Lee YM, Choi HK, Seto CL, Ho JW (2007) Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival. Ann Surg 245(1):1–7CrossRefPubMed
6.
go back to reference Poon JT, Law WL, Wong IW et al (2009) Impact of laparoscopic colorectal resection on surgical site infection. Ann Surg 249(1):77–81CrossRefPubMed Poon JT, Law WL, Wong IW et al (2009) Impact of laparoscopic colorectal resection on surgical site infection. Ann Surg 249(1):77–81CrossRefPubMed
7.
go back to reference Veldkamp R, Kuhry E, Hop WC et al (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6(7):477–484CrossRefPubMed Veldkamp R, Kuhry E, Hop WC et al (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6(7):477–484CrossRefPubMed
8.
go back to reference Basse L, Hjort JD, Billesbolle P, Werner M, Kehlet H (2000) A clinical pathway to accelerate recovery after colonic resection. Ann Surg 232(1):51–57CrossRefPubMed Basse L, Hjort JD, Billesbolle P, Werner M, Kehlet H (2000) A clinical pathway to accelerate recovery after colonic resection. Ann Surg 232(1):51–57CrossRefPubMed
9.
go back to reference Bradshaw BG, Liu SS, Thirlby RC (1998) Standardized perioperative care protocols and reduced length of stay after colon surgery. J Am Coll Surg 186(5):501–506CrossRefPubMed Bradshaw BG, Liu SS, Thirlby RC (1998) Standardized perioperative care protocols and reduced length of stay after colon surgery. J Am Coll Surg 186(5):501–506CrossRefPubMed
10.
go back to reference Delaney CP, Fazio VW, Senagore AJ et al (2001) ‘Fast track’ postoperative management protocol for patients with high co-morbidity undergoing complex abdominal and pelvic colorectal surgery. Br J Surg 88(11):1533–1538CrossRefPubMed Delaney CP, Fazio VW, Senagore AJ et al (2001) ‘Fast track’ postoperative management protocol for patients with high co-morbidity undergoing complex abdominal and pelvic colorectal surgery. Br J Surg 88(11):1533–1538CrossRefPubMed
11.
go back to reference Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA (2007) A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg 245(6):867–872CrossRefPubMed Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA (2007) A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg 245(6):867–872CrossRefPubMed
12.
go back to reference King PM, Blazeby JM, Ewings P et al (2006) Randomized clinical trial comparing laparoscopic and open surgery for colorectal cancer within an enhanced recovery programme. Br J Surg 93(3):300–308CrossRefPubMed King PM, Blazeby JM, Ewings P et al (2006) Randomized clinical trial comparing laparoscopic and open surgery for colorectal cancer within an enhanced recovery programme. Br J Surg 93(3):300–308CrossRefPubMed
13.
go back to reference Nygren J, Soop M, Thorell A, Hausel J, Ljungqvist O (2009) An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients. Dis Colon Rectum 52(5):978–985PubMed Nygren J, Soop M, Thorell A, Hausel J, Ljungqvist O (2009) An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients. Dis Colon Rectum 52(5):978–985PubMed
14.
go back to reference Walter CJ, Collin J, Dumville JC, Drew PJ, Monson JR (2009) Enhanced recovery in colorectal resections: a systematic review and meta-analysis. Colorectal Dis 11(4):344–353CrossRefPubMed Walter CJ, Collin J, Dumville JC, Drew PJ, Monson JR (2009) Enhanced recovery in colorectal resections: a systematic review and meta-analysis. Colorectal Dis 11(4):344–353CrossRefPubMed
15.
go back to reference Wind J, Polle SW, Fung Kon Jin PH et al (2006) Systematic review of enhanced recovery programmes in colonic surgery. Br J Surg 93(7):800–809CrossRefPubMed Wind J, Polle SW, Fung Kon Jin PH et al (2006) Systematic review of enhanced recovery programmes in colonic surgery. Br J Surg 93(7):800–809CrossRefPubMed
16.
go back to reference Kehlet H, Wilmore DW (2002) Multimodal strategies to improve surgical outcome. Am J Surg 183(6):630–641CrossRefPubMed Kehlet H, Wilmore DW (2002) Multimodal strategies to improve surgical outcome. Am J Surg 183(6):630–641CrossRefPubMed
17.
go back to reference Kehlet H, Wilmore DW (2008) Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 248(2):189–198CrossRefPubMed Kehlet H, Wilmore DW (2008) Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 248(2):189–198CrossRefPubMed
18.
19.
go back to reference Basse L, Jakobsen DH, Bardram L et al (2005) Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study. Ann Surg 241(3):416–423CrossRefPubMed Basse L, Jakobsen DH, Bardram L et al (2005) Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study. Ann Surg 241(3):416–423CrossRefPubMed
20.
go back to reference Kehlet H, Mogensen T (1999) Hospital stay of 2 days after open sigmoidectomy with a multimodal rehabilitation programme. Br J Surg 86(2):227–230CrossRefPubMed Kehlet H, Mogensen T (1999) Hospital stay of 2 days after open sigmoidectomy with a multimodal rehabilitation programme. Br J Surg 86(2):227–230CrossRefPubMed
21.
go back to reference Bardram L, Funch-Jensen P, Jensen P, Crawford ME, Kehlet H (1995) Recovery after laparoscopic colonic surgery with epidural analgesia, and early oral nutrition and mobilisation. Lancet 345(8952):763–764CrossRefPubMed Bardram L, Funch-Jensen P, Jensen P, Crawford ME, Kehlet H (1995) Recovery after laparoscopic colonic surgery with epidural analgesia, and early oral nutrition and mobilisation. Lancet 345(8952):763–764CrossRefPubMed
22.
go back to reference Levy BF, Scott MJ, Fawcett WJ, Rockall TA (2009) 23-hour-stay laparoscopic colectomy. Dis Colon Rectum 52(7):1239–1243PubMed Levy BF, Scott MJ, Fawcett WJ, Rockall TA (2009) 23-hour-stay laparoscopic colectomy. Dis Colon Rectum 52(7):1239–1243PubMed
23.
go back to reference Al Chalabi CH, Kavanagh DO, Hassan L et al (2010) The benefit of an enhanced recovery programme following elective laparoscopic sigmoid colectomy. Int J Colorectal Dis Al Chalabi CH, Kavanagh DO, Hassan L et al (2010) The benefit of an enhanced recovery programme following elective laparoscopic sigmoid colectomy. Int J Colorectal Dis
24.
go back to reference Ishiguro S, Yamamoto S, Fujita S et al (2008) Effect of a clinical pathway after laparoscopic surgery for colorectal cancer. Hepatogastroenterology 55(85):1315–1319PubMed Ishiguro S, Yamamoto S, Fujita S et al (2008) Effect of a clinical pathway after laparoscopic surgery for colorectal cancer. Hepatogastroenterology 55(85):1315–1319PubMed
25.
go back to reference Raue W, Haase O, Junghans T et al (2004) ‘Fast-track’ multimodal rehabilitation program improves outcome after laparoscopic sigmoidectomy: a controlled prospective evaluation. Surg Endosc 18(10):1463–1468CrossRefPubMed Raue W, Haase O, Junghans T et al (2004) ‘Fast-track’ multimodal rehabilitation program improves outcome after laparoscopic sigmoidectomy: a controlled prospective evaluation. Surg Endosc 18(10):1463–1468CrossRefPubMed
26.
go back to reference Poon JT, Law WL, Fan JK, Lo OS (2009) Impact of the standardized medial-to-lateral approach on outcome of laparoscopic colorectal resection. World J Surg 33(10):2177–2182CrossRefPubMed Poon JT, Law WL, Fan JK, Lo OS (2009) Impact of the standardized medial-to-lateral approach on outcome of laparoscopic colorectal resection. World J Surg 33(10):2177–2182CrossRefPubMed
27.
go back to reference Basse L, Madsen JL, Kehlet H (2001) Normal gastrointestinal transit after colonic resection using epidural analgesia, enforced oral nutrition and laxative. Br J Surg 88(11):1498–1500CrossRefPubMed Basse L, Madsen JL, Kehlet H (2001) Normal gastrointestinal transit after colonic resection using epidural analgesia, enforced oral nutrition and laxative. Br J Surg 88(11):1498–1500CrossRefPubMed
28.
go back to reference Maessen JM, Dejong CH, Kessels AG, von Meyenfeldt MF (2008) Length of stay: an inappropriate readout of the success of enhanced recovery programs. World J Surg 32(6):971–975CrossRefPubMed Maessen JM, Dejong CH, Kessels AG, von Meyenfeldt MF (2008) Length of stay: an inappropriate readout of the success of enhanced recovery programs. World J Surg 32(6):971–975CrossRefPubMed
29.
go back to reference Abraham NS, Young JM, Solomon MJ (2004) Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer. Br J Surg 91(9):1111–1124CrossRefPubMed Abraham NS, Young JM, Solomon MJ (2004) Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer. Br J Surg 91(9):1111–1124CrossRefPubMed
30.
go back to reference Kehlet H, Kennedy RH (2006) Laparoscopic colonic surgery—mission accomplished or work in progress? Colorectal Dis 8(6):514–517CrossRefPubMed Kehlet H, Kennedy RH (2006) Laparoscopic colonic surgery—mission accomplished or work in progress? Colorectal Dis 8(6):514–517CrossRefPubMed
31.
go back to reference Vlug MS, Wind J, Van der Zaag E et al (2009) Systematic review of laparoscopic vs open colonic surgery within an enhanced recovery programme. Colorectal Dis 11(4):335–343CrossRefPubMed Vlug MS, Wind J, Van der Zaag E et al (2009) Systematic review of laparoscopic vs open colonic surgery within an enhanced recovery programme. Colorectal Dis 11(4):335–343CrossRefPubMed
32.
go back to reference Fotiadis RJ, Badvie S, Weston MD, len-Mersh TG (2004) Epidural analgesia in gastrointestinal surgery. Br J Surg 91(7):828–841CrossRefPubMed Fotiadis RJ, Badvie S, Weston MD, len-Mersh TG (2004) Epidural analgesia in gastrointestinal surgery. Br J Surg 91(7):828–841CrossRefPubMed
33.
go back to reference Grass JA (2000) The role of epidural anesthesia and analgesia in postoperative outcome. Anesthesiol Clin North Am 18(2):407–428, viiiCrossRef Grass JA (2000) The role of epidural anesthesia and analgesia in postoperative outcome. Anesthesiol Clin North Am 18(2):407–428, viiiCrossRef
34.
go back to reference Moraca RJ, Sheldon DG, Thirlby RC (2003) The role of epidural anesthesia and analgesia in surgical practice. Ann Surg 238(5):663–673CrossRefPubMed Moraca RJ, Sheldon DG, Thirlby RC (2003) The role of epidural anesthesia and analgesia in surgical practice. Ann Surg 238(5):663–673CrossRefPubMed
35.
go back to reference Neudecker J, Schwenk W, Junghans T et al (1999) Randomized controlled trial to examine the influence of thoracic epidural analgesia on postoperative ileus after laparoscopic sigmoid resection. Br J Surg 86(10):1292–1295CrossRefPubMed Neudecker J, Schwenk W, Junghans T et al (1999) Randomized controlled trial to examine the influence of thoracic epidural analgesia on postoperative ileus after laparoscopic sigmoid resection. Br J Surg 86(10):1292–1295CrossRefPubMed
36.
go back to reference Senagore AJ, Delaney CP, Mekhail N, Dugan A, Fazio VW (2003) Randomized clinical trial comparing epidural anaesthesia and patient-controlled analgesia after laparoscopic segmental colectomy. Br J Surg 90(10):1195–1199CrossRefPubMed Senagore AJ, Delaney CP, Mekhail N, Dugan A, Fazio VW (2003) Randomized clinical trial comparing epidural anaesthesia and patient-controlled analgesia after laparoscopic segmental colectomy. Br J Surg 90(10):1195–1199CrossRefPubMed
37.
go back to reference Patel GN, Rammos CK, Patel JV, Estes NC (2010) Further reduction of hospital stay for laparoscopic colon resection by modifications of the fast-track care plan. Am J Surg 199(3):391–394CrossRefPubMed Patel GN, Rammos CK, Patel JV, Estes NC (2010) Further reduction of hospital stay for laparoscopic colon resection by modifications of the fast-track care plan. Am J Surg 199(3):391–394CrossRefPubMed
38.
go back to reference Wind J, Hofland J, Preckel B et al (2006) Perioperative strategy in colonic surgery; LAparoscopy and/or FAst track multimodal management versus standard care (LAFA trial). BMC Surg 6:16CrossRefPubMed Wind J, Hofland J, Preckel B et al (2006) Perioperative strategy in colonic surgery; LAparoscopy and/or FAst track multimodal management versus standard care (LAFA trial). BMC Surg 6:16CrossRefPubMed
Metadata
Title
Enhanced recovery program in laparoscopic colectomy for cancer
Authors
Jensen T. C. Poon
Joe K. M. Fan
Oswens S. H. Lo
Wai Lun Law
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 1/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-010-1059-6

Other articles of this Issue 1/2011

International Journal of Colorectal Disease 1/2011 Go to the issue