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01-09-2020 | Endoscopy

Multi-band mucosectomy for neoplasia in patients with Barrett’s esophagus: in vivo comparison between two different devices

Authors: Marco Spadaccini, Pradeep Bhandari, Roberta Maselli, Paola Spaggiari, Asma A. Alkandari, Lazaros Varytimiadis, Rossella Semeraro, Milena Di Leo, Piera Alessia Galtieri, Vincenzo Craviotto, Laura Lamonaca, Ferdinando D’Amico, Simona Attardo, Tatiana Brambilla, Prateek Sharma, Cesare Hassan, Alessandro Repici

Published in: Surgical Endoscopy | Issue 9/2020

Abstract

Background

Multi-band mucosectomy (MBM) is effective and safe for Barrett’s neoplasia. No studies have yet compared the efficacy and safety of the MBM devices commercially available: Duette™ (CookMedical) and Captivator™ (BostonScientific). Our aim is to compare the two devices.

Methods

This is a dual-center retrospective case-control study (Rozzano, Portsmouth) comparing efficacy, safety, and histology of resected specimens between Duette™ (DUE) and Captivator™ (CAPT). Efficacy was assessed by R0 and local recurrence (LR) rate. Bleedings, perforations, and strictures were recorded as safety outcomes. Moreover, the specimens were re-examined by two pathologists, blinded about the study group, to assess the maximum thickness of both the whole specimens and the resected submucosal layer.

Results

Seventy-six patients (38 per group) were included. The two groups did not differ in terms of baseline characteristics. R0 resection was achieved in 96.7% versus 96.3% (p = ns) and LR were recorded in 4/38 (10.5%) versus 3/38 (7.9%) in DUE and CAPT group, respectively (p = ns). Considering Duette™ versus Captivator™, 2 versus 3 patients developed a symptomatic stricture. Only one post-procedural bleeding occurred (Captivator™). Maximum medium thicknesses of specimens and of resected submucosa did not differ between the groups.

Conclusions

MBM is safe and effective for resecting visible lesions using either of the two available devices.

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Title: Multi-band mucosectomy for neoplasia in patients with Barrett’s esophagus: in vivo comparison between two different devices
Authors: Marco Spadaccini
Pradeep Bhandari
Roberta Maselli
Paola Spaggiari
Asma A. Alkandari
Lazaros Varytimiadis
Rossella Semeraro
Milena Di Leo
Piera Alessia Galtieri
Vincenzo Craviotto
Laura Lamonaca
Ferdinando D’Amico
Simona Attardo
Tatiana Brambilla
Prateek Sharma
Cesare Hassan
Alessandro Repici
Publication date: 01-09-2020
Publisher: Springer US
Keywords: Endoscopy
Barrett Esophagus
Published in: Surgical Endoscopy / Issue 9/2020
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-019-07150-w

At a glance: The STEP trials

Springer Medicine

Multi-band mucosectomy for neoplasia in patients with Barrett’s esophagus: in vivo comparison between two different devices

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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