Skip to main content
Top
Published in: BMC Gastroenterology 1/2023

Open Access 01-12-2023 | Endoscopic Retrograde Cholangiopancreatography | Research article

A new classification of periampullary diverticulum: cannulation of papilla on the inner margins of the diverticulum (Type IIa) is more challenging

Authors: He-xian Shi, Yong-qiang Ye, Hai-wang Zhao, De-cai Kong, Shan-zhou Huang, Qian Yan, Yu-bin Chen, Ping Zhang, Sheng Chen, Bao-hua Hou, Chuan-zhao Zhang

Published in: BMC Gastroenterology | Issue 1/2023

Login to get access

Abstract

Background

Periampullary diverticulum (PAD) may make the performance of endoscopic retrograde cholangiopancreatography (ERCP) in patients with choledocholithiasis more difficult and may increase complication rates. The present study evaluated the effects of PAD on first-time ERCP in patients with choledocholithiasis.

Methods

Outcomes were compared in patients with and without PAD and in those with four types of PAD: papilla located completely inside the diverticulum (type I), papilla located in the inner (type II a) and outer (type II b) margins of the diverticulum; and papilla located outside the diverticulum (type III).
Parameters compared included cannulation time and rates of difficult cannulation, post-ERCP pancreatitis (PEP) and perforation.

Results

The median cannulation times in patients with types I, II a, II b, III PAD and in those without PAD were 2.0 min, 5.0 min, 0.67 min, 3.5 min, and 3.5 min, respectively, with difficult cannulation rates in these groups of 7.4%, 31.4%, 8.3%, 18.9%, and 23.2%, respectively. The rates of PEP in patients with and without PAD were 5.3% and 5.1%, respectively. Four patients with and one without PAD experienced perforation.

Conclusions

The division of PAD into four types may be more appropriate than the traditional division into three types. Cannulation of type I and II b PAD was easier than cannulation of patients without PAD, whereas cannulation of type II a PAD was more challenging. PAD may not increase the rates of PEP.
Literature
1.
go back to reference Zoepf T, Zoepf DS, Arnold JC, Benz C, Riemann JF. The relationship between juxtapapillary duodenal diverticula and disorders of the biliopancreatic system: analysis of 350 patients. Gastrointest Endosc. 2001;54(1):56–61.CrossRefPubMed Zoepf T, Zoepf DS, Arnold JC, Benz C, Riemann JF. The relationship between juxtapapillary duodenal diverticula and disorders of the biliopancreatic system: analysis of 350 patients. Gastrointest Endosc. 2001;54(1):56–61.CrossRefPubMed
2.
go back to reference Mohammad Alizadeh AH, Afzali ES, Shahnazi A, et al. ERCP features and outcome in patients with periampullary duodenal diverticulum. ISRN Gastroenterol. 2013;2013:217261.CrossRefPubMedPubMedCentral Mohammad Alizadeh AH, Afzali ES, Shahnazi A, et al. ERCP features and outcome in patients with periampullary duodenal diverticulum. ISRN Gastroenterol. 2013;2013:217261.CrossRefPubMedPubMedCentral
3.
go back to reference Lee JW, Kim JH, Kim YS, et al. The effect of periampullary diverticulum on the outcome of bile duct stone treatment with endoscopic papillary large balloon dilation. Korean J Gastroenterol. 2011;58(4):201–7.CrossRefPubMed Lee JW, Kim JH, Kim YS, et al. The effect of periampullary diverticulum on the outcome of bile duct stone treatment with endoscopic papillary large balloon dilation. Korean J Gastroenterol. 2011;58(4):201–7.CrossRefPubMed
4.
go back to reference Boix J, Lorenzo-Zúñiga V, Añaños F, Domènech E, Morillas RM, Gassull MA. Impact of periampullary duodenal diverticula at endoscopic retrograde cholangiopancreatography: a proposed classification of periampullary duodenal diverticula. Surg Laparosc Endosc Percutan Tech. 2006;16(4):208–11.CrossRefPubMed Boix J, Lorenzo-Zúñiga V, Añaños F, Domènech E, Morillas RM, Gassull MA. Impact of periampullary duodenal diverticula at endoscopic retrograde cholangiopancreatography: a proposed classification of periampullary duodenal diverticula. Surg Laparosc Endosc Percutan Tech. 2006;16(4):208–11.CrossRefPubMed
5.
go back to reference Zippi M, Traversa G, Pica R, et al. Efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) performed in patients with periampullary duodenal diverticula (PAD). Clin Ter. 2014;165(4):e291–4.PubMed Zippi M, Traversa G, Pica R, et al. Efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) performed in patients with periampullary duodenal diverticula (PAD). Clin Ter. 2014;165(4):e291–4.PubMed
6.
go back to reference Karaahmet F, Kekilli M. The presence of periampullary diverticulum increased the complications of endoscopic retrograde cholangiopancreatography. Eur J Gastroenterol Hepatol. 2018;30(9):1009–12.CrossRefPubMed Karaahmet F, Kekilli M. The presence of periampullary diverticulum increased the complications of endoscopic retrograde cholangiopancreatography. Eur J Gastroenterol Hepatol. 2018;30(9):1009–12.CrossRefPubMed
7.
go back to reference Major P, Dembiński M, Winiarski M, et al. A periampullary duodenal diverticula in patient with choledocholithiasis – single endoscopic center experience. Pol Przegl Chir. 2016;88(6):328–33.CrossRefPubMed Major P, Dembiński M, Winiarski M, et al. A periampullary duodenal diverticula in patient with choledocholithiasis – single endoscopic center experience. Pol Przegl Chir. 2016;88(6):328–33.CrossRefPubMed
8.
go back to reference Tham TC, Kelly M. Association of periampullary duodenal diverticula with bile duct stones and with technical success of endoscopic retrograde cholangiopancreatography. Endoscopy. 2004;36(12):1050–3.CrossRefPubMed Tham TC, Kelly M. Association of periampullary duodenal diverticula with bile duct stones and with technical success of endoscopic retrograde cholangiopancreatography. Endoscopy. 2004;36(12):1050–3.CrossRefPubMed
9.
go back to reference Panteris V, Vezakis A, Filippou G, Filippou D, Karamanolis D, Rizos S. Influence of juxtapapillary diverticula on the success or difficulty of cannulation and complication rate. Gastrointest Endosc. 2008;68(5):903–10.CrossRefPubMed Panteris V, Vezakis A, Filippou G, Filippou D, Karamanolis D, Rizos S. Influence of juxtapapillary diverticula on the success or difficulty of cannulation and complication rate. Gastrointest Endosc. 2008;68(5):903–10.CrossRefPubMed
10.
go back to reference Jayaraj M, Mohan BP, Dhindsa BS, et al. Periampullary diverticula and ERCP outcomes: a systematic review and meta-analysis. Dig Dis Sci. 2019;64(5):1364–76.CrossRefPubMed Jayaraj M, Mohan BP, Dhindsa BS, et al. Periampullary diverticula and ERCP outcomes: a systematic review and meta-analysis. Dig Dis Sci. 2019;64(5):1364–76.CrossRefPubMed
11.
go back to reference Corral JE, Mousa OY, Kröner PT, Gomez V, Lukens FJ. Impact of periampullary diverticulum on ERCP performance: a matched case-control study. Clin Endosc. 2019;52(1):65–71.CrossRefPubMed Corral JE, Mousa OY, Kröner PT, Gomez V, Lukens FJ. Impact of periampullary diverticulum on ERCP performance: a matched case-control study. Clin Endosc. 2019;52(1):65–71.CrossRefPubMed
12.
13.
go back to reference Halttunen J, Meisner S, Aabakken L, et al. Difficult cannulation as defined by a prospective study of the Scandinavian Association for Digestive Endoscopy (SADE) in 907 ERCPs. Scand J Gastroenterol. 2014;49(6):752–8.CrossRefPubMed Halttunen J, Meisner S, Aabakken L, et al. Difficult cannulation as defined by a prospective study of the Scandinavian Association for Digestive Endoscopy (SADE) in 907 ERCPs. Scand J Gastroenterol. 2014;49(6):752–8.CrossRefPubMed
14.
go back to reference Liao WC, Angsuwatcharakon P, Isayama H, et al. International consensus recommendations for difficult biliary access. Gastrointest Endosc. 2017;85(2):295–304.CrossRefPubMed Liao WC, Angsuwatcharakon P, Isayama H, et al. International consensus recommendations for difficult biliary access. Gastrointest Endosc. 2017;85(2):295–304.CrossRefPubMed
15.
go back to reference Dumonceau JM, Andriulli A, Elmunzer BJ, et al. Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – updated June 2014. Endoscopy. 2014;46(9):799–815.CrossRefPubMed Dumonceau JM, Andriulli A, Elmunzer BJ, et al. Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – updated June 2014. Endoscopy. 2014;46(9):799–815.CrossRefPubMed
16.
go back to reference Tyagi P, Sharma P, Sharma BC, Puri AS. Periampullary diverticula and technical success of endoscopic retrograde cholangiopancreatography. Surg Endosc. 2009;23(6):1342–5.CrossRefPubMed Tyagi P, Sharma P, Sharma BC, Puri AS. Periampullary diverticula and technical success of endoscopic retrograde cholangiopancreatography. Surg Endosc. 2009;23(6):1342–5.CrossRefPubMed
17.
go back to reference Kim HW, Kang DH, Choi CW, et al. Limited endoscopic sphincterotomy plus large balloon dilation for choledocholithiasis with periampullary diverticula. World J Gastroenterol. 2010;16(34):4335–40.CrossRefPubMedPubMedCentral Kim HW, Kang DH, Choi CW, et al. Limited endoscopic sphincterotomy plus large balloon dilation for choledocholithiasis with periampullary diverticula. World J Gastroenterol. 2010;16(34):4335–40.CrossRefPubMedPubMedCentral
18.
go back to reference Yue P, Zhu KX, Wang HP, et al. Clinical significance of different periampullary diverticulum classifications for endoscopic retrograde cholangiopancreatography cannulation. World J Gastroenterol. 2020;26(19):2403–15.CrossRefPubMedPubMedCentral Yue P, Zhu KX, Wang HP, et al. Clinical significance of different periampullary diverticulum classifications for endoscopic retrograde cholangiopancreatography cannulation. World J Gastroenterol. 2020;26(19):2403–15.CrossRefPubMedPubMedCentral
19.
go back to reference Tabak F, Ji GZ, Miao L. Impact of periampullary diverticulum on biliary cannulation and ERCP outcomes: a single-center experience. Surg Endosc. 2021;35(11):5953–61.CrossRefPubMed Tabak F, Ji GZ, Miao L. Impact of periampullary diverticulum on biliary cannulation and ERCP outcomes: a single-center experience. Surg Endosc. 2021;35(11):5953–61.CrossRefPubMed
20.
go back to reference Tabak F, Ji GZ, Miao L. Impact of periampullary diverticulum on biliary cannulation and ERCP outcomes: a single-center experience. Surg Endosc. 2021;35(11):5953–61.CrossRefPubMed Tabak F, Ji GZ, Miao L. Impact of periampullary diverticulum on biliary cannulation and ERCP outcomes: a single-center experience. Surg Endosc. 2021;35(11):5953–61.CrossRefPubMed
21.
go back to reference Chen L, Xia L, Lu Y, Bie L, Gong B. Influence of periampullary diverticulum on the occurrence of pancreaticobiliary diseases and outcomes of endoscopic retrograde cholangiopancreatography. Eur J Gastroenterol Hepatol. 2017;29(1):105–11.CrossRefPubMed Chen L, Xia L, Lu Y, Bie L, Gong B. Influence of periampullary diverticulum on the occurrence of pancreaticobiliary diseases and outcomes of endoscopic retrograde cholangiopancreatography. Eur J Gastroenterol Hepatol. 2017;29(1):105–11.CrossRefPubMed
22.
go back to reference Chen Q, Zhang Y, Tang Z, Yu M, Liu Z, Zhou X, Li G, Chen Y, Zhou X. The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography. Arch Med Sci. 2020;17(4):905–14.CrossRefPubMedPubMedCentral Chen Q, Zhang Y, Tang Z, Yu M, Liu Z, Zhou X, Li G, Chen Y, Zhou X. The role of periampullary diverticulum on the incidence of pancreaticobiliary diseases and the outcome of endoscopic retrograde cholangiopancreatography. Arch Med Sci. 2020;17(4):905–14.CrossRefPubMedPubMedCentral
Metadata
Title
A new classification of periampullary diverticulum: cannulation of papilla on the inner margins of the diverticulum (Type IIa) is more challenging
Authors
He-xian Shi
Yong-qiang Ye
Hai-wang Zhao
De-cai Kong
Shan-zhou Huang
Qian Yan
Yu-bin Chen
Ping Zhang
Sheng Chen
Bao-hua Hou
Chuan-zhao Zhang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2023
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-023-02862-9

Other articles of this Issue 1/2023

BMC Gastroenterology 1/2023 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.