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Translational Neurodegeneration
Published in:

Open Access 01-12-2017 | Review

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

Authors: Yi Liu, Xiongwei Zhu

Published in: Translational Neurodegeneration | Issue 1/2017

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Abstract

Endoplasmic reticulum (ER) and mitochondria are tubular organelles with a characteristic “network structure” that facilitates the formation of inter-organellar connections. As a result, mitochondria-associated ER membranes (MAMs), a subdomain of the ER that is tightly linked to and communicates with mitochondria, serve multiple physiological functions including lipid synthesis and exchange, calcium signaling, bioenergetics, and apoptosis. Importantly, emerging evidence suggests that the abnormality and dysfunction of MAMs have been involved in various neurodegenerative disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. This review will focus on the architecture and function of MAMs and its involvement in the neurodegenerative diseases.
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Metadata
Title
Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases
Authors
Yi Liu
Xiongwei Zhu
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2017
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/s40035-017-0092-6

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