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01-11-2021 | Endometriosis | Brief Report

Malignant phyllodes tumour of the breast mimicking endometriosis

Authors: Andrew H. S. Lee, Ulises Zanetto, Rachna Awasthi, Mei-Ju Hwang, Nur Diyana Md Nasir, Cedric Chuan Young Ng, Bin Tean Teh, Puay Hoon Tan

Published in: Virchows Archiv | Issue 5/2021

Abstract

A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. The excision also showed a fibroepithelial component with stromal overgrowth, frequent mitoses and invasive margin consistent with a malignant phyllodes tumour. KMT2D and SETD2 mutations were present in both the conventional phyllodes tumour and endometriosis-like areas and are also described in endometriosis raising interesting questions about these lesions. This unusual pattern is a potential diagnostic pitfall, so it is helpful to be aware of it.

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Title: Malignant phyllodes tumour of the breast mimicking endometriosis
Authors: Andrew H. S. Lee
Ulises Zanetto
Rachna Awasthi
Mei-Ju Hwang
Nur Diyana Md Nasir
Cedric Chuan Young Ng
Bin Tean Teh
Puay Hoon Tan
Publication date: 01-11-2021
Publisher: Springer Berlin Heidelberg
Keywords: Endometriosis
Estrogens
Published in: Virchows Archiv / Issue 5/2021
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-021-03086-6

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Springer Medicine

Malignant phyllodes tumour of the breast mimicking endometriosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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