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Open Access 01-12-2023 | Endometriosis | Research

Abnormal expression of fission and fusion genes and the morphology of mitochondria in eutopic and ectopic endometrium

Authors: Chaoshuang Ye, Pei Chen, Bingning Xu, Yang Jin, Yongchao Pan, Tianyu Wu, Yongjiang Du, Jingxia Mao, Ruijin Wu

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Mitochondria play a pivotal role in physiological and metabolic function of the cell. Mitochondrial dynamics orchestrate mitochondrial function and morphology, involving fission and fusion as well as ultrastructural remodeling. Mounting evidence unravels the close link between mitochondria and endometriosis. However, how mitochondrial architecture changes through fission and fusion in eutopic and ectopic tissues of women with ovarian endometriosis remains unknown. We detected the expression of fission and fusion genes and the morphology of mitochondria in eutopic and ectopic endometrium in ovarian endometriosis. The results showed that the expression of DRP1 and LCLAT1 was upregulated in eutopic endometrial stromal cells (ESCs), and the expression of DRP1, OPA1, MFN1, MFN2, and LCLAT1 was significantly downregulated in ectopic ESCs, and reduced number of mitochondria, wider cristae width and narrower cristae junction width was observed, but there was no difference in cell survival rate. The altered mitochondrial dynamics and morphology might, respectively, provide an advantage for migration and adhesion in eutopic ESCs and be the adaptive response in ectopic endometrial cells to survive under hypoxic and oxidative stress environment.

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Title: Abnormal expression of fission and fusion genes and the morphology of mitochondria in eutopic and ectopic endometrium
Authors: Chaoshuang Ye
Pei Chen
Bingning Xu
Yang Jin
Yongchao Pan
Tianyu Wu
Yongjiang Du
Jingxia Mao
Ruijin Wu
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Endometriosis
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01180-w

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Abnormal expression of fission and fusion genes and the morphology of mitochondria in eutopic and ectopic endometrium

Abstract

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