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Archives of Gynecology and Obstetrics

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01-01-2015 | Gynecologic Endocrinology and Reproductive Medicine

Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome

Authors: Jianmei Yu, Yanping Ma, Ze Wu, Yonggang Li, Li Tang, Yunxiu Li, Bo Deng

Published in: Archives of Gynecology and Obstetrics | Issue 1/2015

Abstract

Purpose

To assess which is the optimal protocol in terms of endometrial preparation prior to frozen-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS) and to explore the effect in stimulated cycle with the addition of vaginal 17-β oestradiol.

Methods

Five hundred and seventy-six patients with PCOS were prepared for FET using artificial cycle induced with oestradiol and progesterone supplementation (n = 291) and stimulated cycle induced by human menopausal gonadotrophin (HMG) within or without the addition of vaginal 17-β oestradiol (n = 285). Then the FET was performed in a receptive endometrium.

Results

Endometrial thickness was similar (9.03 ± 1.65 vs. 9.12 ± 1.58, P > 0.05) in artificial and stimulated cycle. The two protocols resulted in clinical pregnancy rate (41.0 % vs. 41.6 %, P > 0.05), ongoing pregnancy rate (36.6 % vs. 34.7 %, P > 0.05), live birth rate (30.0 % vs. 31.7 %, P > 0.05), which were not statistically different. Nevertheless, the cancelled cycle rate made a significant difference (2.2 % vs. 5.4 %, P < 0.05). There is no significant difference in the clinical pregnancy rate in HMG, HMG added with vaginal oestradiol and HMG switch to vaginal oestradiol group (42.6 %, 41.1 %, and 33.3 %, respectively).

Conclusions

The mean endometrial thickness, clinical pregnancy rate, ongoing pregnancy rate, live birth rate and implantation rate were similar in artificial and stimulated cycle for endometrial preparation prior to FET in PCOS. It was fine to add vaginal 17-β oestradiol to stimulated cycle when necessary. However, stimulated cycles had a significantly higher cancelled cycle rate. We should follow the principles of individualization, securitization and optimization in endometrial preparation of the FET in patients with PCOS.

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Title: Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome
Authors: Jianmei Yu
Yanping Ma
Ze Wu
Yonggang Li
Li Tang
Yunxiu Li
Bo Deng
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3396-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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