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Archives of Gynecology and Obstetrics

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01-01-2012 | Reproductive Medicine

Correlation of body mass index with outcome of in vitro fertilization in a developing country

Authors: Neeta Singh, Prerna Gupta, Suneeta Mittal, Neena Malhotra

Published in: Archives of Gynecology and Obstetrics | Issue 1/2012

Abstract

Aims and objective

To correlate ovarian response to stimulation and IVF outcome according to the women’s body mass index (BMI).

Materials and methods

Records of all patients who underwent IVF cycle in our institution from January 2008 to October 2010 were reviewed retrospectively. Three hundred and twenty-eight patients underwent 342 in vitro fertilization (IVF) cycles or intra-cytoplasmic sperm injection (ICSI) and were divided into four subgroups according to BMI; underweight, BMI < 18.5; normal weight, 18.5–24.9; overweight, 25.0–29.9; and obese, >30.0.

Results

In our study, with increasing BMI negative co-relation was seen with clinical pregnancy rate (CPR) (P value = 0.040). Increased doses of gonadotropins were required with increase in patients BMI (P value = 0.045). In the present study, no difference was seen in the number of oocyte retrieved but a decreased fertilization and cleavage rate was seen with decreased number of cryo-preserved embryos with increasing BMI. This study shows that poorer oocyte quality is seen with increasing BMI which results in reduced CPR. In our study no deleterious effect of low BMI was seen on IVF outcome and CPR.

Conclusion

Female obesity impairs IVF outcome potentially by impairing oocyte quality but does not affect ovarian response to stimulation.

Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH (1999) The disease burden associated with overweight and obesity. JAMA 282:1523–1529PubMedCrossRef

Rich-Edwards JW, Goldman MB, Willett WC, Hunter DJ, Stampfer MJ, Colditz GA et al (1994) Adolescent body mass index and infertility caused by ovulatory disorder. Am J Obstet Gynecol 171:171–177PubMed

Zaadstra BM, Seidell JC, Van Noord PA, te Velde ER, Habbema JD, Vrieswijk B et al (1993) Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 306:484–487PubMedCrossRef

Nichols JE, Crane MM, Higdon HL, Miller PB, Boone WR (2003) Extremes of body mass index reduce in vitro fertilization pregnancy rates. Fertil Steril 79:645–647PubMedCrossRef

Wittemer C, Ohl J, Bailly M, Bettahar-Lebugle K, Nisand I (2000) Does body mass index of infertile women have an impact on IVF procedure and outcome? J Assist Reprod Genet 17:547–552PubMedCrossRef

Norman RJ, Clark AM (1998) Obesity and reproductive disorders, a review. Reprod Fertil Dev 10:55–63PubMedCrossRef

Fedorcsak P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N et al (2004) Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 19:2523–2528PubMedCrossRef

Loveland JB, McClamrock H, Malinow A, Sharara F (2001) Increased body mass index has a deleterious effect on in vitro fertilization outcome. J Assist Reprod Genet 18:382–386PubMedCrossRef

Wang JX, Davies M, Normal RJ (2000) Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. Brit Med J 321:1320–1321PubMedCrossRef

10.

Wang JX, Davies MJ, Normal RJ (2002) Obesity increases the risk of spontaneous abortion during infertility treatment. Obstet Res 10:551–554CrossRef

11.

Mulders AG, Laven JS, Eijkemans MJ, Hughes EG, Fauser BC (2004) Patient predictors for outcome of gonadotropin ovulation induction in women with normogonadotrophic anovulatory infertility: a meta-analysis. Hum Reprod Update 9:429–449CrossRef

12.

Fedorcsak P, Dale PO, Storeng R, Tanbo T, Abyholm T (2001) The impact of obesity and insulin resistance on the outcome of IVF or ICSI in women with polycystic ovarian syndrome. Hum Reprod 16:1086–1091PubMedCrossRef

13.

Bellver J, Ayll F, Ferrando M, Melo M, Goyri E, Pellicer A et al (2010) Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 93(2):447–454PubMedCrossRef

14.

Orvieto R, Meltcer S, Nahum R, Rabinson J, Anteby EY, Ashkenazi J (2009) The influence of body mass index on in vitro fertilization outcome. Int J Gynaecol Obstet 104(1):53–55PubMedCrossRef

15.

Maheshwari A, Stofberg L, Bhattacharya S (2007) Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update 13:433–434PubMedCrossRef

16.

Zhang D, Zhu Y, Gao H, Zhou B, Zhang R, Wang T, Ding G, Qu F, Huang H, Lu X (2010) Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecol Endocrinol 26(5):325–332PubMedCrossRef

17.

Bellver J, Melo MAB, Bosch E, Serra V, Remohi J, Pellicer A (2007) Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 88:446–451PubMedCrossRef

18.

Dechaud H, Anahory T, Reyftmann L, Loup V, Hamamah S, Hedon B (2006) Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 127:88–93PubMedCrossRef

19.

Sathya S, Balasubramanyam S, Gupta S, Verma T (2010) Effect of body mass index on in vitro fertilization outcomes in women. J Hum Reprod Sci 3(3):135–138PubMedCrossRef

20.

Vilarino FL, Bianco B, Christofolini DM, Barbosa CP (2010) Impact of body mass index on in vitro fertilization outcomes. Rev Bras Gynecol Obstet 32(11):536–540CrossRef

21.

Lashen H, Ledger W, Bernal AL, Barlow D (1999) Extremes of body mass do not adversely affect the outcome of superovulation and in vitro fertilization. Hum Reprod 14:712–715PubMedCrossRef

22.

Dokras A, Baredziak L, Blaine J, Syrop C, Van Voorhis BJ, Sparks A (2006) Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 108:61–69PubMedCrossRef

23.

Krizanovska K, Ulcova-Gallova Z, Bouse V, Rokyta Z (2002) Obesity and reproductive disorders. Sb Lek 103:517–526PubMed

24.

Shah DK, Missmer SA, Berry KF, Racowsky C, Ginsburg ES (2011) Effect of obesity on oocytes and embryo quality in women undergoing in vitro fertilization. Obstet Gynecol 118(1):63–70PubMedCrossRef

25.

Metwally M, Cutting R, Tipton A, Skull J, Ledger WL, Li TC (2007) Effect of increased body mass index on oocyte and embryo quality in IVF patients. Reprod Biomed Online 15:532–538PubMedCrossRef

Title: Correlation of body mass index with outcome of in vitro fertilization in a developing country
Authors: Neeta Singh
Prerna Gupta
Suneeta Mittal
Neena Malhotra
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 1/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2013-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Correlation of body mass index with outcome of in vitro fertilization in a developing country

Abstract

Aims and objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Aims and objective

Materials and methods

Results

Conclusion

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