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Published in: Neurocritical Care 1/2022

25-05-2022 | Encephalopathy | Viewpoint

What is It Like to be Delirious?

Authors: Eelco F. M. Wijdicks, Alejandro A. Rabinstein

Published in: Neurocritical Care | Issue 1/2022

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Abstract

The current terminology of delirium and encephalopathy is open to debate. As with any poorly understood disorder with an unknown mechanism, there is a range of opinions. Attention must be paid to a proliferation of new terms and the ease with which they were introduced. In this viewpoint article, the authors invite the readers to return to the patient and rethink linguistic usage. The meaning of terms will be determined by their use rather than by authoritative description. We conclude that the suggested terminology of delirium is subjective, unsatisfactory, and may seriously hamper scholarly work. Rather than expand the definitions of types of delirium and separate them from encephalopathy, we advocate a definition—encephalopathy with or without characteristics of delirium—with the understanding that agitated patients in a delirium are innately encephalopathic. We subscribe to the prevailing neurologic description of delirium. This would allow sufficient granularity for bedside use and prospective studies.
Literature
1.
go back to reference Geschwind N. Disorders of attention: a frontier in neuropsychology. Philos Trans R Soc Lond B Biol Sci. 1982;298:173–85.CrossRef Geschwind N. Disorders of attention: a frontier in neuropsychology. Philos Trans R Soc Lond B Biol Sci. 1982;298:173–85.CrossRef
2.
go back to reference Caplan LR. Delirium: a neurologist’s view–the neurology of agitation and overactivity. Rev Neurol Dis. 2010;7:111–8.PubMed Caplan LR. Delirium: a neurologist’s view–the neurology of agitation and overactivity. Rev Neurol Dis. 2010;7:111–8.PubMed
3.
go back to reference Choi SH, Lee H, Chung TS, et al. Neural network functional connectivity during and after an episode of delirium. Am J Psychiatry. 2012;169:498–507.CrossRef Choi SH, Lee H, Chung TS, et al. Neural network functional connectivity during and after an episode of delirium. Am J Psychiatry. 2012;169:498–507.CrossRef
4.
go back to reference van Montfort SJT, van Dellen E, van den Bosch AMR, et al. Resting-state fMRI reveals network disintegration during delirium. Neuroimage Clin. 2018;20:35–41.CrossRef van Montfort SJT, van Dellen E, van den Bosch AMR, et al. Resting-state fMRI reveals network disintegration during delirium. Neuroimage Clin. 2018;20:35–41.CrossRef
5.
go back to reference Boukrina O, Kowalczyk M, Koush Y, Kong Y, Barrett AM. Brain network dysfunction in poststroke delirium and spatial neglect: an fMRI study. Stroke. 2022;53:930–8.CrossRef Boukrina O, Kowalczyk M, Koush Y, Kong Y, Barrett AM. Brain network dysfunction in poststroke delirium and spatial neglect: an fMRI study. Stroke. 2022;53:930–8.CrossRef
6.
go back to reference Grover S, Ghosh A, Ghormode D. Experience in delirium: is it distressing? J Neuropsychiatry Clin Neurosci. 2015;27:139–46.CrossRef Grover S, Ghosh A, Ghormode D. Experience in delirium: is it distressing? J Neuropsychiatry Clin Neurosci. 2015;27:139–46.CrossRef
7.
go back to reference Tenser RB. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2019;380:1778.CrossRef Tenser RB. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2019;380:1778.CrossRef
8.
go back to reference Lipowski ZJ. Delirium (acute confusional states). JAMA. 1987;258:1789–92.CrossRef Lipowski ZJ. Delirium (acute confusional states). JAMA. 1987;258:1789–92.CrossRef
9.
go back to reference Slooter AJC, Otte WM, Devlin JW, et al. Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies. Intensive Care Med. 2020;46:1020–2.CrossRef Slooter AJC, Otte WM, Devlin JW, et al. Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies. Intensive Care Med. 2020;46:1020–2.CrossRef
10.
go back to reference Girard TD, Exline MC, Carson SS, et al. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2018;379:2506–16.CrossRef Girard TD, Exline MC, Carson SS, et al. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2018;379:2506–16.CrossRef
11.
go back to reference Oldham MA, Holloway RG. Delirium disorder: integrating delirium and acute encephalopathy. Neurology. 2020;95:173–8.CrossRef Oldham MA, Holloway RG. Delirium disorder: integrating delirium and acute encephalopathy. Neurology. 2020;95:173–8.CrossRef
12.
go back to reference Glaser GH. Metabolic encephalopathy in hepatic, renal and pulmonary disorders. Postgrad Med. 1960;27:611–9.CrossRef Glaser GH. Metabolic encephalopathy in hepatic, renal and pulmonary disorders. Postgrad Med. 1960;27:611–9.CrossRef
13.
go back to reference Wijdicks EFM. Metabolic encephalopathy: behind the name. Neurocrit Care. 2018;29:385–7.CrossRef Wijdicks EFM. Metabolic encephalopathy: behind the name. Neurocrit Care. 2018;29:385–7.CrossRef
14.
go back to reference Plum F, Posner JB. Diagnosis of Stupor and Coma. 4th ed. Philadelphia: F.A. Davis Company; 1966. Plum F, Posner JB. Diagnosis of Stupor and Coma. 4th ed. Philadelphia: F.A. Davis Company; 1966.
15.
go back to reference Ropper AH, Samuels MA, Klein J. Delirium and other acute confusional states. In: Ropper AH, Samuels MA, editors. Adams and Victor’s principles of neurology. 11th ed. McGraw Hill; 2019. Ropper AH, Samuels MA, Klein J. Delirium and other acute confusional states. In: Ropper AH, Samuels MA, editors. Adams and Victor’s principles of neurology. 11th ed. McGraw Hill; 2019.
16.
go back to reference Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med. 2021;47:1089–103.CrossRef Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med. 2021;47:1089–103.CrossRef
17.
go back to reference Wilson JE, Andrews P, Ainsworth A, Roy K, Ely EW, Oldham MA. Pseudodelirium: psychiatric conditions to consider on the differential for delirium. J Neuropsychiatry Clin Neurosci. 2021;33:356–64.CrossRef Wilson JE, Andrews P, Ainsworth A, Roy K, Ely EW, Oldham MA. Pseudodelirium: psychiatric conditions to consider on the differential for delirium. J Neuropsychiatry Clin Neurosci. 2021;33:356–64.CrossRef
18.
go back to reference Oldham MA, MacLullich A, Slooter AJC. Posttraumatic confusional state: delirium by another name. Arch Phys Med Rehabil. 2021;102:338–9.CrossRef Oldham MA, MacLullich A, Slooter AJC. Posttraumatic confusional state: delirium by another name. Arch Phys Med Rehabil. 2021;102:338–9.CrossRef
Metadata
Title
What is It Like to be Delirious?
Authors
Eelco F. M. Wijdicks
Alejandro A. Rabinstein
Publication date
25-05-2022
Publisher
Springer US
Keyword
Encephalopathy
Published in
Neurocritical Care / Issue 1/2022
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-022-01520-4

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