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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 3-4/2009

01-12-2009

Emerging targeted therapies for bladder cancer: a disease waiting for a drug

Authors: Simon J. Dovedi, Barry R. Davies

Published in: Cancer and Metastasis Reviews | Issue 3-4/2009

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Abstract

Urothelial cell carcinoma is the fifth most common cancer and the costliest to treat. This is largely because of all new cases, about 70% present as superficial disease and this while rarely fatal, tends to recur, requiring long-term follow-up and repeat interventions. The standard of care, intravesical chemo- and immunotherapy, while effective, is associated with a considerable side-effect profile and approximately 30% of patients either fail to respond to treatment or suffer recurrent disease within 5 years. Muscle-invasive bladder cancer is life threatening, showing modest chemosensitivity, and usually requires radical cystectomy. Although bladder cancer is fairly well-genetically characterized, clinical trials with molecularly targeted agents have, in comparison to other solid tumors such as lung, breast and prostate, been few in number and largely unsuccessful, with no new agents being registered in the last 20 years. Hence, bladder cancer represents a considerable opportunity and challenge for molecularly targeted therapy.
Literature
1.
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009). Cancer statistics, 2009. CA: A Cancer Journal for Clinicians, 59, 225–249.
2.
Wu, X. R. (2005). Urothelial tumorigenesis: a tale of divergent pathways. Nature Reviews Cancer, 5, 713–725.PubMed
3.
Zhang, Z. T., Pak, J., Huang, H. Y., Shapiro, E., Sun, T. T., Pellicer, A., et al. (2001). Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation. Oncogene, 20, 1973–1980.PubMed
4.
Zhang, Z. T., Pak, J., Shapiro, E., Sun, T. T., & Wu, X. R. (1999). Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. Cancer Research, 59, 3512–3517.PubMed
5.
Sievert, K. D., Amend, B., Nagele, U., et al. (2009). Economic aspects of bladder cancer: what are the benefits and costs? World Journal of Urology, 27, 295–300.PubMed
6.
Botteman, M. F., Pashos, C. L., Redaelli, A., Laskin, B., & Hauser, R. (2003). The health economics of bladder cancer: a comprehensive review of the published literature. Pharmacoeconomics, 21, 1315–1330.PubMed
7.
Zou, W. (2005). Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nature Reviews Cancer, 5, 263–274.PubMed
8.
Malmström, P., Sylvester, R. J., Crawford, D. E., et al. (2009). An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus Bacillus Calmette–Guérin for non-muscle-invasive bladder cancer. European Urology, 56, 247–256.PubMed
9.
Ponticiello, A., Perna, F., Maione, S., et al. (2004). Analysis of local T lymphocyte subsets upon stimulation with intravesical BCG: a model to study tuberculosis immunity. Respiratory Medicine, 98, 509–514.PubMed
10.
Naoe, M., Ogawa, Y., Takeshita, K., Morita, J., Iwamoto, S., Miyazaki, A., et al. (2007). Bacillus Calmette–Guerin-pulsed dendritic cells stimulate natural killer T cells and gammadeltaT cells. International Journal of Urology, 14, 532. 8; discussion 538.PubMed
11.
van der Meijden, A. P. M., Sylvester, R. J., Oosterlinck, W., Hoeltl, W., & Bono, A. V. (2003). Maintenance Bacillus Calmette–Guerin for Ta T1 bladder tumors is not associated with increased toxicity: results from a European Organisation for Research and Treatment of Cancer Genito-Urinary Group Phase III Trial. European Urology, 44, 429–434.PubMed
12.
Saint, F., Patard, J. J., Maille, P., et al. (2001). T Helper 1/2 lymphocyte urinary cytokine profiles in responding and non-responding patients after 1 and 2 courses of Bacillus Calmette–Guerin for superficial bladder cancer. Journal of Urology, 166, 2142–2147.PubMed
13.
Nadler, R., Luo, Y., Zhao, W., et al. (2003). Interleukin 10 induced augmentation of delayed-type hypersensitivity (DTH) enhances Mycobacterium bovis Bacillus Calmette–Guerin (BCG) mediated antitumour activity. Clinical and Experimental Immunology, 131, 206–216.PubMed
14.
Saint, F., Patard, J. J., Maille, P., et al. (2002). Prognostic value of a T helper 1 urinary cytokine response after intravesical Bacillus Calmette–Guerin treatment for superficial bladder cancer. Journal of Urology, 167, 364–367.PubMed
15.
Luo, Y., Chen, X., Downs, T. M., DeWolf, W. C., & O'Donnell, M. A. (1999). IFN-{alpha} 2B enhances Th1 cytokine responses in bladder cancer patients receiving mycobacterium bovis Bacillus Calmette–Guerin immunotherapy. Journal of Immunology, 162, 2399–2405.
16.
Papageorgiou, A., Lashinger, L., Millikan, R., Grossman, H. B., Benedict, W., Dinney, C. P., et al. (2004). Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells. Cancer Research, 64, 8973–8979.PubMed
17.
Papageorgiou, A., Kamat, A., Benedict, W. F., Dinney, C., & McConkey, D. J. (2006). Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells. Molecular Cancer Therapeutics, 5, 3032–3041.PubMed
18.
Gallagher, B. L., Joudi, F. N., Maymí, J. L., & O’Donnell, M. A. (2008). Impact of previous Bacille Calmette–Guérin failure pattern on subsequent response to Bacille Calmette–Guérin plus interferon intravesical therapy. Urology, 71, 297–301.PubMed
19.
Nepple, K. G., Aubert, H. A., Braasch, M. R., & O'Donnell, M. A. (2009). Combination of BCG and interferon intravesical immunotherapy: an update. World Journal of Urology, 27, 343–346.PubMed
20.
Mohammed, S. I., Knapp, D. W., Bostwick, D. G., et al. (1999). Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Cancer Research, 59, 5647–5650.PubMed
21.
Wheeler, M. A., Hausladen, D. A., Yoon, J. H., & Weiss, R. M. (2002). Prostaglandin E2 production and cyclooxygenase-2 induction in human urinary tract infections and bladder cancer. Journal of Urology, 168, 1568–1573.PubMed
22.
Kim, S Il, Kwon, S. M., Kim, Y. S., & Hong, S. J. (2002). Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer. Urology, 60, 816–821.PubMed
23.
Krysan, K., Reckamp, K. L., Dalwadi, H., Sharma, S., Rozengurt, E., Dohadwala, M., et al. (2005). Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Research, 65, 6275–6281.PubMed
24.
Wang, D., Buchanan, F. G., Wang, H., Dey, S. K., & DuBois, R. N. (2005). Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Research, 65, 1822–1829.PubMed
25.
Pai, R., Soreghan, B., Szabo, I. L., Pavelka, M., Baatar, D., & Tarnawski, A. S. (2002). Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nature Medicine, 8, 289–293.PubMed
26.
Herfs, M., Herman, L., Hubert, P., et al. (2009). High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. Cancer Immunology, Immunotherapy, 58, 603–614.PubMed
27.
Sharma, S., Yang, S., Zhu, L., et al. (2005). Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+CD25+ T regulatory cell activities in lung cancer. Cancer Research, 65, 5211–5220.PubMed
28.
Harizi, H., Juzan, M., Pitard, V., Moreau, J. F., & Gualde, N. (2002). Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. Journal of Immunology, 168, 2255–2263.
29.
Dovedi, S. J., Kirby, J. A., Atkins, H., Davies, B. R., & Kelly, J. D. (2005). Cyclooxygenase-2 inhibition: a potential mechanism for increasing the efficacy of Bacillus Calmette–Guerin immunotherapy for bladder cancer. Journal of Urology, 174, 332. 7; discussion 337.PubMed
30.
Dovedi, S. J., Kirby, J. A., Davies, B. R., Leung, H., & Kelly, J. D. (2008). Celecoxib has potent antitumour effects as a single agent and in combination with BCG immunotherapy in a model of urothelial cell carcinoma. European Urology, 54, 621–630.PubMed
31.
Chambers, M., Marshall, B., Wangoo, A., Bune, A., Cook, H., Shaw, R., et al. (1997). Differential responses to challenge with live and dead Mycobacterium bovis Bacillus Calmette–Guerin. Journal of Immunology, 158, 1742–1748.
32.
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A., Jr. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 388, 394–397.PubMed
33.
Atkins, H., Davies, B. R., Kirby, J. A., & Kelly, J. D. (2003). Polarisation of a T-helper cell immune response by activation of dendritic cells with CpG-containing oligonucleotides: a potential therapeutic regime for bladder cancer immunotherapy. British Journal of Cancer, 89, 2312–2319.PubMed
34.
Olbert, P. J., Schrader, A. J., Simon, C., Dalpke, A., Barth, P., Hofmann, R., et al. (2009). In vitro and in vivo effects of CpG-Oligodeoxynucleotides (CpG-ODN) on murine transitional cell carcinoma and on the native murine urinary bladder wall. Anticancer Research, 29, 2067–2076.PubMed
35.
Mangsbo, S. M., Ninalga, C., Essand, M., Loskog, A., & Totterman, T. H. (2008). CpG therapy is superior to BCG in an orthotopic bladder cancer model and generates CD4+ T-cell immunity. Journal of Immunotherapy, 31, 34–42.PubMed
36.
Filion, M. C., Lepicier, P., Morales, A., & Phillips, N. C. (1999). Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells. British Journal of Cancer, 79, 229–235.PubMed
37.
Kanehira, M., Harada, Y., Takata, R., et al. (2007). Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis. Oncogene, 26, 6448–6455.PubMed
38.
Kanehira, M., Katagiri, T., Shimo, A., et al. (2007). Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Cancer Research, 67, 3276–3285.PubMed
39.
Bergeron, A., Picard, V., LaRue, H., Harel, F., Hovington, H., Lacombe, L., et al. (2009). High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer. International Journal of Cancer, 125, 1365–1371.
40.
Sharma, P., Bajorin, D. F., Jungbluth, A. A., Herr, H., Old, L. J., & Gnjatic, S. (2008). Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF. Journal of Immunotherapy, 31, 849–857.PubMed
41.
Cappellen, D., De Oliveira, C., Ricol, D., et al. (1999). Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nature Genetics, 23, 18–20.PubMed
42.
Billerey, C., Chopin, D., Aubriot-Lorton, M. H., et al. (2001). Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors. American Journal of Pathology, 158, 1955–1959.PubMed
43.
van Rhijn, B. W., Lurkin, I., Radvanyi, F., Kirkels, W. J., van der Kwast, T. H., & Zwarthoff, E. C. (2001). The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Research, 61, 1265–1268.PubMed
44.
Tomlinson, D. C., Baldo, O., Harnden, P., & Knowles, M. A. (2007). FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. Journal of Pathology, 213, 91–98.PubMed
45.
Bernard-Pierrot, I., Brams, A., Dunois-Larde, C., et al. (2006). Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis, 27, 740–747.PubMed
46.
Tomlinson, D. C., Hurst, C. D., & Knowles, M. A. (2007). Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer. Oncogene, 26, 5889–5899.PubMed
47.
Chaffer, C. L., Brennan, J. P., Slavin, J. L., Blick, T., Thompson, E. W., & Williams, E. D. (2006). Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Research, 66, 11271–11278.PubMed
48.
Diez de Medina SG, Chopin, D., El Marjou, A., et al. (1997). Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. Oncogene, 14, 323–330.PubMed
49.
Tomlinson, D. C., Lamont, F. R., Shnyder, S. D., & Knowles, M. A. (2009). Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer. Cancer Research, 69, 4613–4620.PubMed
50.
Qing, J., Du, X., Chen, Y., et al. (2009). Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. Journal of Clinical Investigation, 119, 1216–1229.PubMed
51.
Jebar, A. H., Hurst, C. D., Tomlinson, D. C., Johnston, C., Taylor, C. F., & Knowles, M. A. (2005). FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene, 24, 5218–5225.PubMed
52.
Platt, F. M., Hurst, C. D., Taylor, C. F., Gregory, W. M., Harnden, P., & Knowles, M. A. (2009). Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer. Clinical Cancer Research, 15, 6008–6017.PubMed
53.
Winquist, E., Moore, M. J., Chi, K. N., et al. (2005). A multinomial Phase II study of lonafarnib (SCH 66336) in patients with refractory urothelial cancer. Urol Oncol, 23, 143–149.PubMed
54.
Rosenberg, J. E., von der Maase, H., Seigne, J. D., et al. (2005). A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinoma. Cancer, 103, 2035–2041.PubMed
55.
Brunner, T. B., Hahn, S. M., Gupta, A. K., Muschel, R. J., McKenna, W. G., & Bernhard, E. J. (2003). Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Research, 63, 5656–5668.PubMed
56.
Davies, B. R., Logie, A., McKay, J. S., et al. (2007). AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Molecular Cancer Therapeutics, 6, 2209–2219.PubMed
57.
Kassouf, W., Black, P. C., Tuziak, T., et al. (2008). Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. Journal of Urology, 179, 353–358.PubMed
58.
Philips, G. K., Halabi, S., Sanford, B. L., Bajorin, D., Small, E. J., & for the Cancer and Leukemia Group B. (2009). A phase II trial of cisplatin (C), gemcitabine (G) and gefitinib for advanced urothelial tract carcinoma: results of Cancer and Leukemia Group B (CALGB) 90102. Annals of Oncology, 20, 1074–1079.PubMed
59.
Inoue, K., Slaton, J. W., Perrotte, P., et al. (2000). Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. Clinical Cancer Research, 6, 4874–4884.PubMed
60.
Perrotte, P., Matsumoto, T., Inoue, K., et al. (1999). Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clinical Cancer Research, 5, 257–265.PubMed
61.
Lynch, T. J., Bell, D. W., Sordella, R., et al. (2004). Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New England Journal of Medicine, 350, 2129–2139.PubMed
62.
Villares, G. J., Zigler, M., Blehm, K., Bogdan, C., McConkey, D., Colin, D., et al. (2007). Targeting EGFR in bladder cancer. World Journal of Urology, 25, 573–579.PubMed
63.
Jacobs, M. A., Wotkowicz, C., Baumgart, E. D., et al. (2007). Epidermal growth factor receptor status and the response of bladder carcinoma cells to erlotinib. Journal of Urology, 178, 1510–1514.PubMed
64.
Blehm, K. N., Spiess, P. E., Bondaruk, J. E., et al. (2006). Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy. Clinical Cancer Research, 12, 4671–4677.PubMed
65.
Black, P. C., Brown, G. A., Inamoto, T., et al. (2008). Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells. Clinical Cancer Research, 14, 1478–1486.PubMed
66.
Wulfing, C., Machiels, J. P., Richel, D. J., et al. (2009). A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma. Cancer, 115, 2881–2890.PubMed
67.
Hussain, M. H., MacVicar, G. R., Petrylak, D. P., et al. (2007). Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial. Journal of Clinical Oncology, 25, 2218–2224.PubMed
68.
Kim, L. C., Song, L., & Haura, E. B. (2009). Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol, 6, 587–595.PubMed
69.
Engelman, J. A. (2009). Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nature Reviews Cancer, 9, 550–562.PubMed
70.
Cappellen, D., Gil Diez de Medina, S., Chopin, D., Thiery, J. P., & Radvanyi, F. (1997). Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder. Oncogene, 14, 3059–3066.PubMed
71.
Cairns, P., Evron, E., Okami, K., et al. (1998). Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene, 16, 3215–3218.PubMed
72.
Aveyard, J. S., Skilleter, A., Habuchi, T., & Knowles, M. A. (1999). Somatic mutation of PTEN in bladder carcinoma. British Journal of Cancer, 80, 904–908.PubMed
73.
Wang, Z., Zhang, Z., Liu, Y., et al. (2000). Effect of retinoic acid and its complexes with transition metals on human bladder cancer cell line EJ in vitro. Urological Research, 28, 191–195.PubMed
74.
Tsuruta, H., Kishimoto, H., Sasaki, T., et al. (2006). Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Research, 66, 8389–8396.PubMed
75.
Lopez-Knowles, E., Hernandez, S., Malats, N., et al. (2006). PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Research, 66, 7401–7404.PubMed
76.
Knowles, M. A., Habuchi, T., Kennedy, W., & Cuthbert-Heavens, D. (2003). Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder. Cancer Research, 63, 7652–7656.PubMed
77.
Habuchi, T., Devlin, J., Elder, P. A., & Knowles, M. A. (1995). Detailed deletion mapping of chromosome 9q in bladder cancer: evidence for two tumour suppressor loci. Oncogene, 11, 1671–1674.PubMed
78.
Sonpavde, G., Jian, W., Liu, H., Wu, M. F., Shen, S. S., & Lerner, S. P. (2009). Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical model. Urol Oncol, 27, 391–399.PubMed
79.
Davis, D. W., Inoue, K., Dinney, C. P., Hicklin, D. J., Abbruzzese, J. L., & McConkey, D. J. (2004). Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253 J B-V bladder cancer xenografts. Cancer Research, 64, 4601–4610.PubMed
80.
Inoue, K., Slaton, J. W., Davis, D. W., et al. (2000). Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel. Clinical Cancer Research, 6, 2635–2643.PubMed
81.
Vazquez, A., Bond, E. E., Levine, A. J., & Bond, G. L. (2008). The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov, 7, 979–987.PubMed
82.
Bolderson, E., Richard, D. J., Zhou, B. B., & Khanna, K. K. (2009). Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clinical Cancer Research, 15, 6314–6320.PubMed
83.
Kuball, J., Wen, S. F., Leissner, J., et al. (2002). Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation. Journal of Clinical Oncology, 20, 957–965.PubMed
84.
Hsieh, J. T., Dinney, C. P., & Chung, L. W. (2000). The potential role of gene therapy in the treatment of bladder cancer. Urologic Clinics of North America, 27, 103. 13, ix.PubMed
85.
Pagliaro, L. C. (2000). Gene therapy for bladder cancer. World Journal of Urology, 18, 148–151.PubMed
86.
Li, Y., Pong, R. C., Bergelson, J. M., et al. (1999). Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy. Cancer Research, 59, 325–330.PubMed
87.
Siemens, D. R., Crist, S., Austin, J. C., Tartaglia, J., & Ratliff, T. L. (2003). Comparison of viral vectors: gene transfer efficiency and tissue specificity in a bladder cancer model. Journal of Urology, 170, 979–984.PubMed
88.
Fodor, I., Timiryasova, T., Denes, B., Yoshida, J., Ruckle, H., & Lilly, M. (2005). Vaccinia virus mediated p53 gene therapy for bladder cancer in an orthotopic murine model. Journal of Urology, 173, 604–609.PubMed
89.
Kikuchi, E., Menendez, S., Ohori, M., Cordon-Cardo, C., Kasahara, N., & Bochner, B. H. (2004). Inhibition of orthotopic human bladder tumor growth by lentiviral gene transfer of endostatin. Clinical Cancer Research, 10, 1835–1842.PubMed
90.
Tao, Z., Connor, R. J., Ashoori, F., Dinney, C. P., Munsell, M., Philopena, J. A., et al. (2006). Efficacy of a single intravesical treatment with Ad-IFN/Syn 3 is dependent on dose and urine IFN concentration obtained: implications for clinical investigation. Cancer Gene Therapy, 13, 125–130.PubMed
91.
Rosser, C. J., Benedict, W. F., & Dinney, C. P. (2001). Gene therapy for superficial bladder cancer. Expert Rev Anticancer Ther, 1, 531–539.PubMed
92.
Yamashita, M., Rosser, C. J., Zhou, J. H., et al. (2002). Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer. Cancer Gene Therapy, 9, 687–691.PubMed
93.
Graves, P. R., Yu, L., Schwarz, J. K., Gales, J., Sausville, E. A., O'Connor, P. M., et al. (2000). The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. Journal of Biological Chemistry, 275, 5600–5605.PubMed
94.
Ashwell, S., Janetka, J. W., & Zabludoff, S. (2008). Keeping checkpoint kinases in line: new selective inhibitors in clinical trials. Expert Opinion on Investigational Drugs, 17, 1331–1340.PubMed
95.
Zabludoff, S. D., Deng, C., Grondine, M. R., et al. (2008). AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Molecular Cancer Therapeutics, 7, 2955–2966.PubMed
96.
Blasina, A., Hallin, J., Chen, E., et al. (2008). Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Molecular Cancer Therapeutics, 7, 2394–2404.PubMed
97.
Oldenhuis, C. N., Stegehuis, J. H., Walenkamp, A. M., de Jong, S., & de Vries, E. G. (2008). Targeting TRAIL death receptors. Current Opinion in Pharmacology, 8, 433–439.PubMed
98.
Koschny, R., Holland, H., Sykora, J., et al. (2007). Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Clinical Cancer Research, 13, 3403–3412.PubMed
99.
Liu, X., Yue, P., Chen, S., Hu, L., Lonial, S., Khuri, F. R., et al. (2007). The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells. Cancer Research, 67, 4981–4988.PubMed
100.
Voortman, J., Checinska, A., & Giaccone, G. (2007). The proteasomal and apoptotic phenotype determine bortezomib sensitivity of non-small cell lung cancer cells. Mol Cancer, 6, 73.PubMed
101.
Smith, M. R., Jin, F., & Joshi, I. (2007). Bortezomib sensitizes non-Hodgkin's lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors TRAIL-R1 and TRAIL-R2. Clinical Cancer Research, 13, 5528s–5534s.PubMed
102.
Gomez-Abuin, G., Winquist, E., Stadler, W. M., Pond, G., Degendorfer, P., Wright, J., et al. (2007). A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia. Investigational New Drugs, 25, 181–185.PubMed
103.
Rosenberg, J. E., Halabi, S., Sanford, B. L., et al. (2008). Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207. Annals of Oncology, 19, 946–950.PubMed
104.
Kamat, A. M., Karashima, T., Davis, D. W., et al. (2004). The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo. Molecular Cancer Therapeutics, 3, 279–290.PubMed
105.
Nogawa, M., Yuasa, T., Kimura, S., et al. (2005). Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. Journal of Clinical Investigation, 115, 978–985.PubMed
Metadata
Title
Emerging targeted therapies for bladder cancer: a disease waiting for a drug
Authors
Simon J. Dovedi
Barry R. Davies
Publication date
01-12-2009
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 3-4/2009
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-009-9192-9

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