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Open Access 01-12-2016 | Review

Elotuzumab for the treatment of multiple myeloma

Authors: Yucai Wang, Larysa Sanchez, David S. Siegel, Michael L. Wang

Published in: Journal of Hematology & Oncology | Issue 1/2016

Abstract

Elotuzumab is one of the first two monoclonal antibodies that gained FDA approval for the treatment of multiple myeloma (MM). It targets SLAMF7, which is highly expressed in normal plasma and MM cells as well as natural killer (NK) cells. Elotuzumab demonstrated significant anti-myeloma activity in preclinical studies, and its mechanisms of action include mediating antibody-dependent cell-mediated cytotoxicity, enhancing cytotoxicity of NK cells, and inhibiting MM cell interaction with bone marrow stromal cells. In clinical trials, elotuzumab in combination with immunomodulatory drugs and proteasome inhibitors has demonstrated an excellent efficacy and safety profile in treating MM.

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Title: Elotuzumab for the treatment of multiple myeloma
Authors: Yucai Wang
Larysa Sanchez
David S. Siegel
Michael L. Wang
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2016
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-016-0284-z

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