Published in:
Open Access
01-12-2016 | Research
Elevated glycated hemoglobin levels impair blood pressure in children and adolescents with type 1 diabetes mellitus
Authors:
Sandra de Oliveira, Dahan da Cunha Nascimento, Ramires Alsamir Tibana, Samuel Lima de Oliveira, Ivo Vieira de Sousa Neto, Roberta Kelly Menezes Maciel Falleiros, Leonardo Garcia Miranda, Hermelinda Cordeiro Pedrosa, James Wilfred Navalta, Guilherme Borges Pereira, Jonato Prestes
Published in:
Diabetology & Metabolic Syndrome
|
Issue 1/2016
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Abstract
Background
Deregulation of glycemic and glycated hemoglobin (HbA1) levels accelerate the progression of cardiovascular complications in type 1 diabetes mellitus (T1DM). The aim of this study was to investigate the association between HbA1 and changes in blood pressure of children and adolescents with T1DM.
Methods
A total of 60 children and adolescents were recruited and allocated into two groups (prehypertension and control group). Blood pressure and HbA1 were measured by the oscillometric method and high-performance liquid chromatography, respectively.
Results
The prehypertensive group had (P < 0.05) higher disease duration, body weight, Z score for body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and a higher HbA1 when compared with the control children and adolescents. Multiple regression to predict alterations in DBP from HbA1 adjusted for age, disease duration, and body mass index demonstrated a positive relationship with DBP (P < 0.05). A 1 % increase in HbA1 was associated with 1.73 mmHg increase in DBP.
Conclusions
High levels of HbA1 may be associated with increased blood pressure in T1DM. A tight control of HbA1 levels may provide long-term cardiovascular protection in children and adolescents with T1DM.