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Open Access 01-12-2013 | Short paper

Elevated CSF histamine levels in multiple sclerosis patients

Authors: Ulf Kallweit, Kosuke Aritake, Claudio L Bassetti, Stephan Blumenthal, Osamu Hayaishi, Michael Linnebank, Christian R Baumann, Yoshihiro Urade

Published in: Fluids and Barriers of the CNS | Issue 1/2013

Abstract

Background

Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.

Findings

CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003).

Conclusions

Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.

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Title: Elevated CSF histamine levels in multiple sclerosis patients
Authors: Ulf Kallweit
Kosuke Aritake
Claudio L Bassetti
Stephan Blumenthal
Osamu Hayaishi
Michael Linnebank
Christian R Baumann
Yoshihiro Urade
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Fluids and Barriers of the CNS / Issue 1/2013
Electronic ISSN: 2045-8118
DOI: https://doi.org/10.1186/2045-8118-10-19

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Elevated CSF histamine levels in multiple sclerosis patients

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusions

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