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Journal of Diabetes & Metabolic Disorders

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01-12-2018 | Research Article

Elastic aortic wrap reduced aortic stiffness by partially alleviating the impairment of cholesterol efflux capacity in pigs

Authors: Shutan Liao, Qing Zhou, Yang Zhang

Published in: Journal of Diabetes & Metabolic Disorders | Issue 2/2018

Abstract

Purpose

Metabolic syndrome patients exhibit impaired cholesterol efflux capacity. Previous studies have shown a positive association between aortic stiffness and metabolic syndrome. However, it is unknown whether cholesterol efflux capacity participates in the process of aortic stiffness. This study sought to determine the effect of metabolic syndrome on aortic stiffening, and to investigate the effectiveness of aortic wraps on aortic compliance and the underlying mechanisms.

Methods

In a swine model of metabolic syndrome, we compared the cholesterol efflux capacity and aortic compliance responding to diet modifications and aortic wrap applications.

Results

Metabolic syndrome induced by high cholesterol diet significantly decreased cholesterol efflux capacity and aortic compliance. Elastic aortic wrap application increased aortic compliance and partially restored cholesterol efflux capacity via ATP binding cassette transporter A1 (ABCA1) pathway.

Conclusions

Cholesterol efflux plays a role in aortic stiffening. Elastic aortic wrap application could be a potential treatment for aortic stiffness related to metabolic syndrome.

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Title: Elastic aortic wrap reduced aortic stiffness by partially alleviating the impairment of cholesterol efflux capacity in pigs
Authors: Shutan Liao
Qing Zhou
Yang Zhang
Publication date: 01-12-2018
Publisher: Springer International Publishing
Published in: Journal of Diabetes & Metabolic Disorders / Issue 2/2018
Electronic ISSN: 2251-6581
DOI: https://doi.org/10.1007/s40200-018-0345-7

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