Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-10-2015 | Head and Neck

Efficiency of three-dimensional Doppler ultrasonography in assessing nodal metastasis of head and neck cancer

Authors: San-Fu Hong, Yu-Shih Lai, Kwo-Whei Lee, Mu-Kuan Chen

Published in: European Archives of Oto-Rhino-Laryngology | Issue 10/2015

Abstract

The aim of this study was to assess the clinical usefulness of three-dimensional (3D) color Doppler ultrasonography with a novel predictive model in the detection of cervical metastasis of untreated head and neck squamous cell carcinoma patients. We assessed cervical lymph node metastasis in 52 head and neck squamous cell carcinoma patients by 3D color Doppler ultrasonography, magnetic resonance imaging, and [¹⁸F] fluorodeoxyglucose positron emission tomography with computed tomography. Pathologic analysis was used as the gold standard for evaluation of these imaging modalities. The rate of correct N staging was 84.6 % on ultrasonography, 55.8 % on magnetic resonance imaging, and 71.2 % on positron emission tomography/computed tomography. On a level-by-level basis, the ultrasonography had 78.9 % sensitivity, 99.0 % specificity, 93.8 % positive predictive value, 96.0 % negative predictive value, and 95.7 % accuracy. It also showed the highest agreement to histology results as compared with magnetic resonance imaging and positron emission tomography/computed tomography (kappa value = 0.832, 0.506, and 0.537, respectively). 3D Doppler ultrasonography with our prediction model provides a rapid, low-cost, noninvasive, and reliable method with low inter-observation variations for detecting neck metastasis of head and neck squamous cell carcinoma patients.

Brown AE, Langdon JD (1995) Management of oral cancer. Ann R Coll Surg Engl 77:404–408PubMedCentralPubMed

Annual Report of Cancer Registry (2010) Department of Health, Executive Yuan

Layland MK, Sessions DG, Lenox J (2005) The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+. Laryngoscope 115:629–639CrossRefPubMed

van den Brekel MW, Castelijns JA, Stel HV, Golding RP, Meyer CJ, Snow GB (1993) Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study. Eur Arch Otorhinolaryngol 250:11–17CrossRefPubMed

de Bondt RB, Nelemans PJ, Hofman PA et al (2007) Detection of lymph node metastases in head and neck cancer: a meta-analysis comparing US, USgFNAC, CT, and MR imaging. Eur J Radiol 64:266–272CrossRefPubMed

Yamazaki Y, Saitoh M, Notani K et al (2008) Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer. Ann Nucl Med 22:177–184CrossRefPubMed

Yoon DY, Hwang HS, Chang SK et al (2009) CT, MR, US, 18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck. Eur Radiol 19:634–642CrossRefPubMed

Civantos FJ, Stoeckli SJ, Takes RP et al (2010) What is the role of sentinel lymph node biopsy in the management of oral cancer in 2010? Eur Arch Otorhinolaryngol 267:839–844PubMedCentralCrossRefPubMed

Liao LJ, Lo WC, Hsu WJ, Wang CT, Lai MS (2012) Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck-a meta-analysis comparing different imaging modalities. BMC Cancer 12:236PubMedCentralCrossRefPubMed

10.

Lai YS, Kuo CY, Chen MK, Chen HC (2013) 3-D Doppler ultrasonography in assessing nodal metastases and staging of head and neck cancer. Laryngoscope 123:3037–3042CrossRefPubMed

11.

Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–617CrossRefPubMed

12.

Som PM (1992) Detection of metastasis in cervical lymph nodes: CT and MR criteria and differential diagnosis. AJR Am J Roentgenol 158:961–969CrossRefPubMed

13.

Richards PS, Peacock TE (2007) The role of ultrasound in the detection of cervical lymph node metastases in clinically N0 squamous cell carcinoma of the head and neck. Cancer Imaging 7:167–178PubMedCentralCrossRefPubMed

14.

Madison MT, Remley KB, Latchaw RE (1994) Mitchell SL Radiologic diagnosis and staging of head and neck squamous cell carcinoma. Radiol Clin North Am 32:163–181PubMed

15.

Ng SH, Yen TC, Liao CT et al (2006) Prospective study of [18F]Fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonanceimaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol 24:4371–4376CrossRefPubMed

16.

Ng SH, Yen TC, Liao CT et al (2005) 18 F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med 46:1136–1143PubMed

17.

Don DM, Anzai Y, Lufkin RB, Fu YS, Calcaterra TC (1995) Evaluation of cervical lymph node metastases in squamous cell carcinoma of the head and neck. Laryngoscope 105:669–674CrossRefPubMed

18.

Lonneux M, Hamoir M, Reychler H et al (2010) Positron emission tomography with [18F]fluorodeoxyglucose improves staging and patient management in patients with head and neck squamous cell carcinoma: a multicenter prospective study. J Clin Oncol 28:1190–1195CrossRefPubMed

19.

Nakasone Y, Inoue T, Oriuchi N, Takeuchi K, Negishi A, Endo K, Mogi K (2001) The role of whole-body FDG-PET in preoperative assessment of tumor staging in oral cancers. Ann Nucl Med 15:505–512CrossRefPubMed

20.

Kyzas PA, Evangelou E, Denaxa-Kyza D, Ioannidis JPA (2008) 18F-Fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst 100:712–720CrossRefPubMed

21.

Stoeckli SJ, Haerle SK, Strobel K, Haile SR, Hany TF, Schuknecht B (2012) Initial staging of the neck in head and neck squamous cell carcinoma: a comparison of CT, PET/CT, and ultrasound-guided fine-needle aspiration cytology. Head Neck 34:469–476CrossRefPubMed

22.

Borgemeester MC, van den Brekel MWM, van Tinteren H et al (2008) Ultrasound-guided aspiration cytology for the assessment of the clinically N0 neck: factors influencing its accuracy. Head Neck 30:1505–1513CrossRefPubMed

23.

Wu CH, Lee MM, Huang KC, Ko JY, Sheen TS, Hsieh FJ (2000) A probability prediction rule for malignant cervical lymphadenopathy using sonography. Head Neck 22:223–228CrossRefPubMed

Title: Efficiency of three-dimensional Doppler ultrasonography in assessing nodal metastasis of head and neck cancer
Authors: San-Fu Hong
Yu-Shih Lai
Kwo-Whei Lee
Mu-Kuan Chen
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 10/2015
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-3256-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Efficiency of three-dimensional Doppler ultrasonography in assessing nodal metastasis of head and neck cancer

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 10/2015

Development of hypoparathyroidism animal model and the feasibility of small intestinal submucosa application on the parathyroid autotransplantation

Suture of the mucosa after the endoscopic LASER mucomyotomy of Zenker’s diverticulum

Complications of balloon packing in epistaxis

Barbed reposition pharyngoplasty (BRP) for OSAHS: a feasibility, safety, efficacy and teachability pilot study. “We are on the giant’s shoulders”

Preoperative assessment and classification of benign laryngotracheal stenosis: a consensus paper of the European Laryngological Society

Optical magnification devices in tonsillectomy: a prospective randomised clinical study