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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2020

Open Access 01-12-2020 | Primary research

Efficacy of the interpersonal and social rhythm therapy (IPSRT) in patients with bipolar disorder: results from a real-world, controlled trial

Authors: Luca Steardo Jr, Mario Luciano, Gaia Sampogna, Francesca Zinno, Pasquale Saviano, Filippo Staltari, Cristina Segura Garcia, Pasquale De Fazio, Andrea Fiorillo

Published in: Annals of General Psychiatry | Issue 1/2020

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Abstract

Background

Bipolar disorder (BD) is one of the most burdensome mental disorder, with a lifetime prevalence of 2.4%, with a prevalence of 0.6% for bipolar type I and 0.4% for bipolar type II. Several interventions have been developed to implement the treatment strategy of bipolar disorder, including the Interpersonal and Social Rhythm Therapy (IPSRT). This intervention has been specifically developed to manage patients’ stressful life events, improve the disruptions of social and circadian rhythms and increase adherence to medications. The aim of the present study is to assess the efficacy of IPSRT on affective and anxiety psychopathology, social functioning, response to pharmacological treatment and affective morbidity index (AMI) in BD patients.

Methods

BD patients were consecutively recruited at the Mood Disorder Unit of the University of Campania “Luigi Vanvitelli” and randomly assigned to the experimental group receiving the IPSRT or to the Treatment as Usual (TAU) group. Patients were assessed at baseline, after 3 and 6 months with several validated assessment tools and with the affective morbidity index.

Results

At the end of the intervention, compared to controls, patients from the experimental group reported a significant improvement in anxious depressive and manic symptomatology, global functioning; and response to mood stabilizers. Patients in the IPSRT group reported a reduction at the AMI score.

Conclusions

IPSRT has been confirmed to be effective in improving the clinical symptomology of BD patients and in improving the affective morbidity index. Further studies with longer follow-up are needed in order to assess the stability of the results.
Trial registration The study was approved by the local ethical review board (N001567/28.01.2018)
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Metadata
Title
Efficacy of the interpersonal and social rhythm therapy (IPSRT) in patients with bipolar disorder: results from a real-world, controlled trial
Authors
Luca Steardo Jr
Mario Luciano
Gaia Sampogna
Francesca Zinno
Pasquale Saviano
Filippo Staltari
Cristina Segura Garcia
Pasquale De Fazio
Andrea Fiorillo
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2020
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-020-00266-7

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