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Clinical Oral Investigations
Published in: Clinical Oral Investigations 4/2016

01-05-2016 | Review

Efficacy of parathyroid hormone supplementation on the osseointegration of implants: a systematic review

Authors: Fawad Javed, Mohammad D. Al Amri, Sergio Varela Kellesarian, Abdulaziz A. Al-Kheraif, Fahim Vohra, José Luis Calvo-Guirado, Hans Malmstrom, Georgios E. Romanos

Published in: Clinical Oral Investigations | Issue 4/2016

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Abstract

Objective

The aim of the present systematic review was to assess the efficacy of parathyroid hormone supplementation on the osseointegration of implants.

Methods

The addressed focused question was Does parathyroid hormone supplementation affect osseointegration around implants? Indexed databases were searched from 1965 up to and including April 2015 using various key words including: Bone to implant contact; implant; parathyroid hormone; and osseointegration. Letters to the Editor, case-reports/case-series, historic reviews, commentaries and articles published in languages other than English were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data.

Results

Eighteen studies fulfilled the eligibility criteria. Evidence was limited to preclinical animal studies only (11 studies in rodents, 4 in dogs and 3 in rabbits). Number of titanium implants placed ranged between 20 and 80 implants. Results from 16 studies showed that PTH supplementation enhanced new bone formation and/or BIC around implants. One study suggests that PTH-coated implants improve BIC and BA. One study showed no significant difference in BIC and new bone formation around implants with PTH hydrogel placement.

Conclusion

Efficacy of PTH supplementation on osseointegration of implants shows promising results in animal models, however further investigation is necessary to assess the effectiveness in humans.
Appendix
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Metadata
Title
Efficacy of parathyroid hormone supplementation on the osseointegration of implants: a systematic review
Authors
Fawad Javed
Mohammad D. Al Amri
Sergio Varela Kellesarian
Abdulaziz A. Al-Kheraif
Fahim Vohra
José Luis Calvo-Guirado
Hans Malmstrom
Georgios E. Romanos
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 4/2016
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-015-1691-1

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