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01-02-2004 | Poster presentation

Efficacy of levosimendan in shock

Authors: A McLean, S Huang, D Stewart, M Nalos, B Tang

Published in: Critical Care | Special Issue 1/2004

Excerpt

Levosimendan is used intravenously for the management of heart failure. At the therapeutic dose, levosimendan acts predominantly as a calcium sensitizer and ATP-sensitive K⁺-channel (KATP-channel) opener. It binds directly to the calcium-dependent site on troponin C, stabilizing the calcium-induced conformational change and enhances the calcium sensitivity of the cardiac myofilaments. The advantages of a calcium sensitizer over dobutamine is the lack of intracellular calcium overload and that it acts without increasing the energy demand for handling intracellular calcium. …

Title: Efficacy of levosimendan in shock
Authors: A McLean
S Huang
D Stewart
M Nalos
B Tang
Publication date: 01-02-2004
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2004
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc2550

Keynote webinar | Spotlight on medication adherence

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Efficacy of levosimendan in shock

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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