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01-02-2004 | Poster presentation

Strict blood glucose control with insulin improves hepatic mitochondrial ultrastructure and function in critical illness

Authors: I Vanhorebeek, R De Vos, P Wouters, F Weekers, D Mesotten, G Van den Berghe

Published in: Critical Care | Special Issue 1/2004

Excerpt

Hyperglycemia and insulin resistance are common in critical illness. Recently, a reduction of morbidity and mortality of patients in a surgical ICU by maintaining normoglycemia with insulin has been demonstrated [1]. Studies on mitochondria in sepsis [2] and other critical illness and on hyperglycemia in diabetes [3] suggested that the effects of this therapy on mitochondrial integrity and oxidative stress state may contribute to the positive results of the treatment. …

Van den Berghe , et al.: N Engl J Med 2001, 345: 1359. 10.1056/NEJMoa011300CrossRefPubMed

Brealey : . The Lancet 2002, 360: 219. 10.1016/S0140-6736(02)09459-XCrossRef

Brownlee : Nature 2001, 414: 813. 10.1038/414813aCrossRefPubMed

Title: Strict blood glucose control with insulin improves hepatic mitochondrial ultrastructure and function in critical illness
Authors: I Vanhorebeek
R De Vos
P Wouters
F Weekers
D Mesotten
G Van den Berghe
Publication date: 01-02-2004
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2004
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc2715

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Strict blood glucose control with insulin improves hepatic mitochondrial ultrastructure and function in critical illness

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Keynote webinar | Spotlight on medication adherence

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