Top

Published in:

01-07-2016 | Original Communication

Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study

Authors: Costanza Pazzaglia, F. Camerota, M. Germanotta, E. Di Sipio, C. Celletti, L. Padua

Published in: Journal of Neurology | Issue 7/2016

Abstract

Patients affected by Charcot-Marie-Tooth (CMT) disease experience an impaired balance. Although the causes of the postural instability are not fully understood, somatosensory system seems to play a key role. Mechanical vibration seems to act on the somatosensory system and to improve its function. The aim of our study was to evaluate the effects of focal mechanical vibration (fMV) on the balance of CMT 1A patients. We enrolled 14 genetically confirmed CMT 1A patients (8 female and 6 male, mean age 492 years, range 32–74, mean duration of disease: 13 years, range 1–30). Patients underwent a 3-day fMV treatment on quadriceps and triceps surae and were evaluated before the treatment as well as 1 week and 1 month after the end of the treatment. The primary outcome measure was the Berg Balance Scale (BBS) and the secondary were the Dynamic Gait Index (DGI), the 6 Min Walking Test (6MWT), the muscular strength of lower limbs, the Quality of Life (QoL) questionnaire and the stabilometric variables. The statistical analysis showed a significant modification of the BBS due to the effect of treatment (p < 0.05). A significant modification was also found in the DGI (p < 0.05). Concerning the stabilometric variables we found significant changes only for the eyes closed condition; in particular, a significant decrease was found in Velocity_ML (p < 0.05) and Sway path length (p < 0.05). The fMV treatment applied on lower limbs of CMT 1A patients determined an improvement of balance as detected by the BBS. The concurrent improvement of stabilometric variables in the eyes closed condition only suggests that fMV acts mostly on somatosensory afferences. Further studies are needed to confirm these data on a larger sample of CMT patients.

Available only for authorised users

Pareyson D, Scaioli V, Laurà M (2006) Clinical and electrophysiological aspects of Charcot-Marie-Tooth disease. Neuromol Med 8:3–22. doi:10.1385/NMM:8:1:123 CrossRef

Padua L, Aprile I, Cavallaro T et al (2008) Relationship between clinical examination, quality of life, disability and depression in CMT patients: Italian multicenter study. Neurol Sci 29:157–162. doi:10.1007/s10072-008-0928-z CrossRefPubMed

Vinci P, Perelli S, Esposito C (2001) Charcot-Marie-Tooth disease: poor balance and rehabilitation. J Peripher Nerv Syst 6:58. doi:10.1046/j.1529-8027.2001.01007-51.x CrossRef

van der Linden MH, van der Linden SC, Hendricks HT et al (2010) Postural instability in Charcot-Marie-Tooth type 1A patients is strongly associated with reduced somatosensation. Gait Posture 31:483–488. doi:10.1016/j.gaitpost.2010.02.005 CrossRefPubMed

Lencioni T, Piscosquito G, Rabuffetti M et al (2015) The influence of somatosensory and muscular deficits on postural stabilization: insights from an instrumented analysis of subjects affected by different types of Charcot-Marie-Tooth disease. Neuromuscul Disord 25:640–645. doi:10.1016/j.nmd.2015.05.003 CrossRefPubMedPubMedCentral

Nardone A, Tarantola J, Miscio G et al (2000) Loss of large-diameter spindle afferent fibres is not detrimental to the control of body sway during upright stance: evidence from neuropathy. Exp Brain Res 135:155–162CrossRefPubMed

Lencioni T, Rabuffetti M, Piscosquito G et al (2014) Postural stabilization and balance assessment in Charcot-Marie-Tooth 1A subjects. Gait Posture 40:481–486. doi:10.1016/j.gaitpost.2014.07.006 CrossRefPubMedPubMedCentral

Filippi GM, Brunetti O, Botti FM et al (2009) Improvement of stance control and muscle performance induced by focal muscle vibration in young-elderly women: a randomized controlled trial. Arch Phys Med Rehabil 90:2019–2025. doi:10.1016/j.apmr.2009.08.139 CrossRefPubMed

Bianconi R, van der Meulen J (1963) The response to vibration of the end organs of mammalian muscle spindles. J Neurophysiol 26:177–190PubMed

10.

Matthews PB, Watson JD (1981) Action of vibration on the response of cat muscle spindle Ia afferents to low frequency sinusoidal stretching. J Physiol 317:365–381CrossRefPubMedPubMedCentral

11.

Fattorini L, Ferraresi A, Rodio A et al (2006) Motor performance changes induced by muscle vibration. Eur J Appl Physiol 98:79–87. doi:10.1007/s00421-006-0250-5 CrossRefPubMed

12.

Fallon JB, Macefield VG (2007) Vibration sensitivity of human muscle spindles and Golgi tendon organs. Muscle Nerve 36:21–29. doi:10.1002/mus.20796 CrossRefPubMed

13.

Sorensen KL, Hollands MA, Patla E (2002) The effects of human ankle muscle vibration on posture and balance during adaptive locomotion. Exp Brain Res 143:24–34. doi:10.1007/s00221-001-0962-z CrossRefPubMed

14.

Murillo N, Valls-Sole J, Vidal J et al (2014) Focal vibration in neurorehabilitation. Eur J Phys Rehabil Med 50:231–242PubMed

15.

Brunetti O, Filippi GM, Lorenzini M et al (2006) Improvement of posture stability by vibratory stimulation following anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 14:1180–1187. doi:10.1007/s00167-006-0101-2 CrossRefPubMed

16.

Celletti C, Fattorini L, Camerota F et al (2015) Focal muscle vibration as a possible intervention to prevent falls in elderly women: a pragmatic randomized controlled trial. Aging Clin Exp Res 27:857–863. doi:10.1007/s40520-015-0356-x CrossRefPubMed

17.

Celletti C, Castori M, Galli M et al (2011) Evaluation of balance and improvement of proprioception by repetitive muscle vibration in a 15-year-old girl with joint hypermobility syndrome. Arthritis Care Res Hoboken 63:775–779. doi:10.1002/acr.20434 CrossRefPubMed

18.

Shy ME, Rose MR (2005) Charcot-Marie-Tooth disease impairs quality of life: why? And how do we improve it? Neurology 65:790–791. doi:10.1212/01.wnl.0000181027.21574.df CrossRefPubMed

19.

Berg KO, Wood-Dauphinee SL, Williams JI, Maki B (1992) Measuring balance in the elderly: validation of an instrument. Can J Public Health 83(2):S7–S11PubMed

20.

Monti Bragadin M, Francini L, Bellone E et al (2015) Tinetti and Berg balance scales correlate with disability in hereditary peripheral neuropathies: a preliminary study. Eur J Phys Rehabil Med 51:423–427PubMed

21.

Shumway-Cook A, Taylor CS, Matsuda PN et al (2013) Expanding the scoring system for the Dynamic Gait Index. Phys Ther 93:1493–1506. doi:10.2522/ptj.20130035 CrossRefPubMed

22.

Kierkegaard M, Tollbäck A (2007) Reliability and feasibility of the 6 min walk test in subjects with myotonic dystrophy. Neuromuscul Disord 17:943–949. doi:10.1016/j.nmd.2007.08.003 CrossRefPubMed

23.

McDonald CM, Henricson EK, Han JJ et al (2010) The 6-min walk test as a new outcome measure in Duchenne muscular dystrophy. Muscle Nerve 41:500–510. doi:10.1002/mus.21544 CrossRefPubMed

24.

Padua L, Pazzaglia C, Pareyson D et al (2016) Novel outcome measures for Charcot-Marie-Tooth disease: validation and reliability of 6 min walk test and StepWatchTM Activity Monitor and identification of the walking features more related to a better Quality of Life. Eur J Neurol. doi:10.1111/ene.13033 PubMed

25.

McCluskey D (1989) Aids to the examination of the peripheral nervous system. Ulster Med J, Memorandum. Her Majesty’s Stationary Office (ed), London, p 201

26.

Apolone G, Mosconi P (1998) The Italian SF-36 Health Survey: translation, validation and norming. J Clin Epidemiol 51:1025–1036CrossRefPubMed

27.

Padua L, Pareyson D, Aprile I et al (2008) Natural history of CMT1A including QoL: a 2-year prospective study. Neuromuscul Disord 18:199–203. doi:10.1016/j.nmd.2007.11.008 CrossRefPubMed

28.

Oliveira LF, Simpson DM, Nadal J (1996) Calculation of area of stabilometric signals using principal component analysis. Physiol Meas 17:305–312CrossRefPubMed

29.

Lapole T, Pérot C (2010) Effects of repeated Achilles tendon vibration on triceps surae force production. J Electromyogr Kinesiol 20:648–654. doi:10.1016/j.jelekin.2010.02.001 CrossRefPubMed

30.

Gandevia SC (2001) Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81:1725–1789PubMed

31.

Courtine G, De Nunzio AM, Schmid M et al (2007) Stance- and locomotion-dependent processing of vibration-induced proprioceptive inflow from multiple muscles in humans. J Neurophysiol 97:772–779. doi:10.1152/jn.00764.2006 CrossRefPubMed

32.

Marconi B, Filippi GM, Koch G et al (2008) Long-term effects on motor cortical excitability induced by repeated muscle vibration during contraction in healthy subjects. J Neurol Sci 275:51–59. doi:10.1016/j.jns.2008.07.025 CrossRefPubMed

33.

Caliandro P, Celletti C, Padua L et al (2012) Focal muscle vibration in the treatment of upper limb spasticity: a pilot randomized controlled trial in patients with chronic stroke. Arch Phys Med Rehabil 93:1656–1661. doi:10.1016/j.apmr.2012.04.002 CrossRefPubMed

34.

Piscosquito G, Reilly MM, Schenone A et al (2015) Responsiveness of clinical outcome measures in Charcot-Marie-Tooth disease. Eur J Neurol 22:1556–1563. doi:10.1111/ene.12783 CrossRefPubMed

35.

Pareyson D, Reilly MM, Schenone A et al (2011) Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial. Lancet Neurol 10:320–328. doi:10.1016/S1474-4422(11)70025-4 CrossRefPubMedPubMedCentral

36.

Priplata AA, Niemi JB, Harry JD et al (2003) Vibrating insoles and balance control in elderly people. Lancet Lond Engl 362:1123–1124. doi:10.1016/S0140-6736(03)14470-4 CrossRef

37.

Lipsitz LA, Lough M, Niemi J et al (2015) A shoe insole delivering subsensory vibratory noise improves balance and gait in healthy elderly people. Arch Phys Med Rehabil 96:432–439. doi:10.1016/j.apmr.2014.10.004 CrossRefPubMed

38.

Tinetti ME, Williams TF, Mayewski R (1986) Fall risk index for elderly patients based on number of chronic disabilities. Am J Med 80:429–434CrossRefPubMed

39.

Aprile I, Di Sipio E, Germanotta M et al (2016) Muscle focal vibration in healthy subjects: evaluation of the effects on upper limb motor performance measured using a robotic device. Eur J Appl Physiol 116:729–737. doi:10.1007/s00421-016-3330-1 CrossRefPubMed

40.

Rosenkranz K, Rothwell JC (2004) The effect of sensory input and attention on the sensorimotor organization of the hand area of the human motor cortex. J Physiol 561:307–320. doi:10.1113/jphysiol.2004.069328 CrossRefPubMedPubMedCentral

41.

Recanzone GH, Merzenich MM, Jenkins WM et al (1992) Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. J Neurophysiol 67:1031–1056PubMed

Title: Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study
Authors: Costanza Pazzaglia
F. Camerota
M. Germanotta
E. Di Sipio
C. Celletti
L. Padua
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 7/2016
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-016-8157-5

At a glance: The STEP trials

Springer Medicine

Efficacy of focal mechanic vibration treatment on balance in Charcot-Marie-Tooth 1A disease: a pilot study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 7/2016

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

Reversing the trend: interventions to treat intracranial haemorrhage associated with anticoagulation

The interrelationship between disease severity, dynamic stability, and falls in cerebellar ataxia

Design, set-up and utility of the UK facioscapulohumeral muscular dystrophy patient registry

The diagnostic value of biexponential apparent diffusion coefficients in myopathy

Multiple sclerosis in men: management considerations