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01-03-2012 | Original Article

Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata

Authors: Tongyu Cao Wikramanayake, Rosa Rodriguez, Sonal Choudhary, Lucia M. Mauro, Keyvan Nouri, Lawrence A. Schachner, Joaquin J. Jimenez

Published in: Lasers in Medical Science | Issue 2/2012

Abstract

Alopecia areata (AA) is a common autoimmune disease that presents with non-scarring alopecia. It is characterized by intra- or peri-follicular lymphocytic infiltrates composed of CD4+ and CD8+ T-cells on histology. To this day, few treatments are effective for AA. Here we present findings of using a low-level laser comb to alleviate the symptoms of AA in a C3H/HeJ mouse model for AA. Fourteen C3H/HeJ mice with induced AA were used in this study. Two were killed to confirm AA through histology. The remaining 12 mice were randomized into two groups; group I received HairMax LaserComb (wavelength: 655 nm, beam diameter <5 mm; divergence 57 mrad; nine lasers) for 20 s daily, three times per week for a total of 6 weeks; group II was treated similarly, except that the laser was turned off (sham-treated). After 6 weeks of LaserComb treatment, hair regrowth was observed in all the mice in group I (laser-treated) but none in group II (sham-treated). On histology, increased number of anagen hair follicles was observed in laser-treated mice. On the other hand, sham-treated mice demonstrated hair follicles in the telogen phase with no hair shaft. LaserComb seems to be an effective and convenient device for the treatment of AA in the C3H/HeJ mouse model. Human studies are required to determine the efficacy and safety of this device for AA therapy.

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Title: Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata
Authors: Tongyu Cao Wikramanayake
Rosa Rodriguez
Sonal Choudhary
Lucia M. Mauro
Keyvan Nouri
Lawrence A. Schachner
Joaquin J. Jimenez
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Lasers in Medical Science / Issue 2/2012
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-011-0953-7

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Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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