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01-03-2015 | Original Article

Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity

Authors: Roberta Ceci, Guglielmo Duranti, Paolo Sgrò, Massimiliano Sansone, Laura Guidetti, Carlo Baldari, Stefania Sabatini, Luigi Di Luigi

Published in: European Journal of Applied Physiology | Issue 3/2015

Abstract

Introduction

Physical exercise is associated with enhanced production of reactive oxygen species, which if uncontrolled can result in tissue injury. Phosphodiesterase type 5 inhibitors (PDE5i) exhibit protective effect against oxidative stress, both in animals and healthy/unhealthy humans. However, the effect of a chronic administration of PDE5i, particularly combined with physical exercise, has never been investigated.

Purpose

The present study was designed to evaluate the effect of the long-acting PDE5i tadalafil on oxidative status and muscle damage after exhaustive exercise in healthy males included in a double-blind crossover trial.

Hypothesis

Tadalafil, having a putative antioxidant activity, may reduce oxidative damage after strenuous exercise.

Methods

Each volunteer randomly received two tablets of placebo or tadalafil (20 mg/day) with 36 h of interval before performing exhaustive exercise. After 2 weeks of washout, the volunteers were crossed over. Blood samples were collected immediately before exercise, immediately after, and during recovery (15, 30, 60 min). Plasma total antioxidant status, glutathione homeostasis (GSH/GSSG), malondialdehyde (MDA), protein carbonyls, creatine kinase (CK), lactate dehydrogenase (LDH) and the inflammatory cytokine interleukin 6 were assessed.

Results

Tadalafil administration per se affected redox homeostasis (GSH/GSSG −36 %; p < 0.05), cellular (CK +75 % and LDH +36 %; p < 0.05) and oxidative damage (MDA +41 % and protein carbonyls +50 %; p < 0.05) markers. The exhaustive exercise increased all the above-reported biochemical parameters, with subjects from the tadalafil group showing significantly higher values with respect to the placebo group.

Conclusions

A prolonged exposure to tadalafil decreases antioxidant capacity at resting condition, therefore making subjects more susceptible to the oxidative stress induced by an exhaustive bout of exercise.

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Title: Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity
Authors: Roberta Ceci
Guglielmo Duranti
Paolo Sgrò
Massimiliano Sansone
Laura Guidetti
Carlo Baldari
Stefania Sabatini
Luigi Di Luigi
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 3/2015
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-014-3040-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity

Abstract

Introduction

Purpose

Hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Purpose

Hypothesis

Methods

Results

Conclusions

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