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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 4/2013

01-12-2013 | Osteoporosis and Cancer (P Taxel, Section Editor)

Effects of Radiation on Bone

Authors: Rafael Pacheco, Harlan Stock

Published in: Current Osteoporosis Reports | Issue 4/2013

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Abstract

Ionizing radiation produces its deleterious biologic effects by both direct (DNA strand breaks) and indirect processes (formation of free oxygen radicals). Mitotically active cells are more susceptible to the detrimental effects of ionizing radiation. These effects are most severe locally within the treatment field but can also occur systemically, possibly reflecting hormonal influences and inflammatory cytokine mediators. Specific bone complications of radiation include osteopenia, growth arrest, fracture and malignancy. Some of these complications, such as osteopenia, are reversible and severity is dose dependent. Insufficiency fractures are a common complication after radiation therapy and generally affect those bones under most physiologic stress and with the highest ratio of trabecular to cortical bone. Familiarity with the radiographic appearance of irradiated bone, including computed tomography (CT) and magnetic resonance imaging (MRI), will improve image interpretation and facilitate accurate diagnosis.
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Metadata
Title
Effects of Radiation on Bone
Authors
Rafael Pacheco
Harlan Stock
Publication date
01-12-2013
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 4/2013
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-013-0174-z

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