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Journal of Interventional Cardiac Electrophysiology
Published in: Journal of Interventional Cardiac Electrophysiology 2/2015

01-08-2015

Effects of low-level carotid baroreflex stimulation on atrial electrophysiology

Authors: Mingyan Dai, Mingwei Bao, Jiafen Liao, Lilei Yu, Yanhong Tang, He Huang, Xi Wang, Congxin Huang

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 2/2015

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Abstract

Purpose

This study aimed to investigate the effects of low-level carotid baroreflex stimulation (LL-CBS) on atrial electrophysiology.

Methods

In protocol 1 (LL-CBS on physiological state), anesthetized rabbits were subjected to LL-CBS (n = 10) or surgical exposure (n = 6) for 1 h. In protocol 2 (LL-CBS on acute rapid atrial pacing), anesthetized rabbits underwent 3 h of rapid atrial pacing (RAP) with concomitant LL-CBS in the third hour (n = 7) or 3h-RAP without LL-CBS (n = 6). Carotid baroreceptor surrounded by electrodes allowed LL-CBS at 20 % below the voltage required to reduce systolic blood pressure or heart rate. Effective refractory period (ERP) and monophasic action potential duration (MAPD) were determined, and power spectral of heart rate variability (HRV) was analyzed at baseline as well as after interventions in all groups, respectively.

Results

In protocol 1, LL-CBS significantly prolonged the ERPs, MAPD90, and MAPD50 and increased high-frequency (HF) HRV component but it decreased low-frequency (LF) HRV component and LF/HF ratio. In protocol 2, 3h-RAP significantly shortened ERPs, MAPD90, and MAPD50 and decreased HF but it increased LF and LF/HF ratio. However, LL-CBS reversed the variations caused by RAP.

Conclusions

LL-CBS prolongs ERPs and MAPD of the left atrium and attenuates RAP-induced atrial electrical remodeling including the shortening of ERPs and MAPD, probably by modulating the autonomic nervous system.
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Metadata
Title
Effects of low-level carotid baroreflex stimulation on atrial electrophysiology
Authors
Mingyan Dai
Mingwei Bao
Jiafen Liao
Lilei Yu
Yanhong Tang
He Huang
Xi Wang
Congxin Huang
Publication date
01-08-2015
Publisher
Springer US
Published in
Journal of Interventional Cardiac Electrophysiology / Issue 2/2015
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI
https://doi.org/10.1007/s10840-015-9976-5

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