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The journal of nutrition, health & aging
Published in: The journal of nutrition, health & aging 5/2017

01-05-2017

Effects of gender and age on immune responses of human peripheral blood mononuclear cells to probiotics: A large scale pilot study

Authors: Y.-H. Ho, Y.-T. Huang, Y.-C. Lu, S.-Y. Lee, M.-F. Tsai, S.-P. Hung, Ting-Yuan Hsu

Published in: The journal of nutrition, health & aging | Issue 5/2017

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Abstract

Background

Despite the widely accepted concept that probiotics confer miscellaneous benefits to hosts, the controversies surrounding these health-promoting claims cannot be ignored. These controversies hinder development and innovation in this field.

Results

To clarify the effects of age and gender on probiotic-induced immune responses, we recruited 1613 Taiwanese individuals and calculated the ratio of IFN-γ to IL-10 production after each individual’s PBMCs were stimulated by six probiotic strains (L. paracasei BRAP01, L. acidophilus AD300, B. longum BA100, E. faecium BR0085, L. rhamnosus AD500 and L. reuteri BR101). Our results indicated that gender and age have only minor effects on the immune modulation of probiotics. Additionally, we showed that L. paracasei BRAP01 and L. acidophilus AD300 are the two dominant strains inducing IFN-γ/IL-10 production in Taiwanese individuals and that L. reuteri BR101 was the most effective stimulator of IL-10/IFN-γ. Additionally, a significant inverse relationship between the ability of L. paracasei BRAP01 and L. rhamnosus AD500 to stimulate IFN-γ/IL-10 or IL-10/IFN-γ production was also observed.

Conclusions

Our results indicated that age and gender have only minor effects on the immune modulation abilities of probiotics.
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Metadata
Title
Effects of gender and age on immune responses of human peripheral blood mononuclear cells to probiotics: A large scale pilot study
Authors
Y.-H. Ho
Y.-T. Huang
Y.-C. Lu
S.-Y. Lee
M.-F. Tsai
S.-P. Hung
Ting-Yuan Hsu
Publication date
01-05-2017
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 5/2017
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-016-0818-7

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