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01-09-2014 | Head and Neck

Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: an MRI evaluation

Authors: Hing-Chiu Chang, Chun-Jung Juan, Hui-Chu Chiu, Cheng-Chieh Cheng, Su-Chin Chiu, Yi-Jui Liu, Hsiao-Wen Chung, Hsian-He Hsu

Published in: European Radiology | Issue 9/2014

Abstract

Objectives

To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements.

Methods

A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat–water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique.

Results

Parotid fat content was larger in men than in women by about 10 percentage points (P < 0.005), and positively associated with BMI and age for both genders (mostly with P < 0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women (P < 0.005), but showed no gender difference if measured using fat-saturated PROPELLER (P = 0.840). The negative association between parotid ADC and age/BMI/fat (P < 0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data.

Conclusions

Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation.

Key Points

• Parotid fat content in healthy adults correlates positively with age and BMI.

• The rate of aging-related increase in fat contents is gender-dependent.

• Parotid ADC measurements are strongly influenced by fat saturation.

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Title: Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: an MRI evaluation
Authors: Hing-Chiu Chang
Chun-Jung Juan
Hui-Chu Chiu
Cheng-Chieh Cheng
Su-Chin Chiu
Yi-Jui Liu
Hsiao-Wen Chung
Hsian-He Hsu
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 9/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3265-z

At a glance: The STEP trials

Springer Medicine

Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: an MRI evaluation

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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