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Archives of Dermatological Research
Published in: Archives of Dermatological Research 1/2013

01-01-2013 | Short Communication

Effects of Cervi cornus Colla (deer antler glue) in the reconstruction of a skin equivalent model

Authors: Jandi Kim, Hyo-Soon Jeong, Hailan Li, Kwang Jin Baek, Nyoun Soo Kwon, Hye-Young Yun, Hye-Ryung Choi, Kyoung-Chan Park, Dong-Seok Kim

Published in: Archives of Dermatological Research | Issue 1/2013

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Abstract

The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the basal layer of the epidermis in the HA and CCC model. Involucrin was obviously expressed in the upper layer of the epidermis in the HA and CCC model. Moreover, we observed that integrins α6 and β1 were strongly expressed along the basement membrane zone in the HA and CCC model, in which the dermis expressing type I collagen was more compact. In conclusion, our data indicate that CCC contributed to the formation of epidermis, basement membrane, and extracellular matrix in the reconstruction of SE and suggest that CCC may be a useful adjuvant in the reconstruction of SE.
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Metadata
Title
Effects of Cervi cornus Colla (deer antler glue) in the reconstruction of a skin equivalent model
Authors
Jandi Kim
Hyo-Soon Jeong
Hailan Li
Kwang Jin Baek
Nyoun Soo Kwon
Hye-Young Yun
Hye-Ryung Choi
Kyoung-Chan Park
Dong-Seok Kim
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Archives of Dermatological Research / Issue 1/2013
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-012-1283-8

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